Exploring HCN channels as novel drug targets

Discovery of a novel series of selective HCN1 blockers

(2011) Kelly J. McClure et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HCN3 Contributes to the Ventricular Action Potential Waveform in the Murine Heart

(2011) Stefanie Fenske et al.   CIRCULATION RESEARCH

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

Postnatal maturation of the hyperpolarization-activated cation current, Ih, in trigeminal sensory neurons

(2011) Hyun-jung Cho et al.   JOURNAL OF NEUROPHYSIOLOGY

Local Anesthetic Inhibits Hyperpolarization-Activated Cationic Currents

(2011) Q.-t. Meng et al.   MOLECULAR PHARMACOLOGY

TRIP8b Splice Forms Act in Concert to Regulate the Localization and Expression of HCN1 Channels in CA1 Pyramidal Neurons

(2011) Rebecca Piskorowski et al.   NEURON

The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel

(2011) Verena Hammelmann et al.   PLoS One

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

(2011) M. Baruscotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

(2011) E. C. Emery et al.   SCIENCE

The Role of the Funny Current in Pacemaker Activity

(2010) Dario DiFrancesco   CIRCULATION RESEARCH

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

(2010) Patrick A. Schweizer et al.   Circulation-Arrhythmia and Electrophysiology

Increased seizure severity and seizure-related death in mice lacking HCN1 channels

(2010) Bina Santoro et al.   EPILEPSIA

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mutation in the HCN4 Gene Causes Symptomatic Sinus Bradycardia in Moroccan Jews

(2010) AVISHAG LAISH-FARKASH et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Design, Synthesis, and Preliminary Biological Evaluation of New Isoform-Selective f-Current Blockers

(2010) Michele Melchiorre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotine Blocks the Hyperpolarization-Activated Current Ih and Severely Impairs the Oscillatory Behavior of Oriens-Lacunosum Moleculare Interneurons

(2010) M. Griguoli et al.   JOURNAL OF NEUROSCIENCE

Downregulation of Dendritic HCN Channel Gating in Epilepsy Is Mediated by Altered Phosphorylation Signaling

(2010) S. Jung et al.   JOURNAL OF NEUROSCIENCE

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

(2010) Karl Swedberg et al.   LANCET

HCN channels in behavior and neurological disease: Too hyper or not active enough?

(2010) Alan S. Lewis et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HCN-related channelopathies

(2010) Mirko Baruscotti et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ivabradine: Beyond heart rate control

(2009) Graziano Riccioni et al.   ADVANCES IN THERAPY

Augmented currents of an HCN2 variant in patients with febrile seizure syndromes

(2009) Leanne M. Dibbens et al.   ANNALS OF NEUROLOGY

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels and Pain

(2009) J. Dunlop et al.   CURRENT PHARMACEUTICAL DESIGN

If Inhibition with Ivabradine

(2009) Irina Savelieva et al.   DRUG SAFETY

Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis

(2009) Z. Huang et al.   JOURNAL OF NEUROSCIENCE

Low-Conductance HCN1 Ion Channels Augment the Frequency Response of Rod and Cone Photoreceptors

(2009) A. J. Barrow et al.   JOURNAL OF NEUROSCIENCE

Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function

(2009) A. S. Lewis et al.   JOURNAL OF NEUROSCIENCE

The pelvis–kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis

(2009) Romulo Hurtado et al.   KIDNEY INTERNATIONAL

Ivabradine: Pharmacodynamic aspects of its clinical use

(2009) J. Stieber   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Tripping the HCN Breaker

(2009) Diane Lipscombe et al.   NEURON

Association with the Auxiliary Subunit PEX5R/Trip8b Controls Responsiveness of HCN Channels to cAMP and Adrenergic Stimulation

(2009) Gerd Zolles et al.   NEURON

TRIP8b Splice Variants Form a Family of Auxiliary Subunits that Regulate Gating and Trafficking of HCN Channels in the Brain

(2009) Bina Santoro et al.   NEURON

Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine

(2009) H.-J. Cho et al.   NEUROSCIENCE

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of Ih in epilepsy

(2009) Jonas Dyhrfjeld-Johnsen   Frontiers in Neuroscience

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP

(2008) Dagmar Harzheim et al.   EMBO JOURNAL

Light responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene

(2008) Gabriel C. Knop et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular basis of funny current (If) in normal and failing human heart

(2008) Francesca Stillitano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tamoxifen-inducible gene deletion in the cardiac conduction system

(2008) Evelyn Hoesl et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Subunit-Specific Effects of Isoflurane on Neuronal Ih in HCN1 Knockout Mice

(2008) Xiangdong Chen et al.   JOURNAL OF NEUROPHYSIOLOGY

Role of the hyperpolarization-activated currentIhin somatosensory neurons

(2008) Aliakmal Momin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial

(2008) Kim Fox et al.   LANCET

Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial

(2008) Kim Fox et al.   LANCET

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy

(2008) Minyoung Shin et al.   NEUROBIOLOGY OF DISEASE

Characteristics of HCN Channels and Their Participation in Neuropathic Pain

(2008) Yu-Qiu Jiang et al.   NEUROCHEMICAL RESEARCH

Reciprocal modulation of I h and I TASK in thalamocortical relay neurons by halothane

(2008) Thomas Budde et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS

K+ Channel Regulator KCR1 Suppresses Heart Rhythm by Modulating the Pacemaker Current If

(2008) Guido Michels et al.   PLoS One

Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks

(2008) Roland A. Bender et al.   PROGRESS IN NEUROBIOLOGY

Cellular mechanisms underlying the pharmacological induction of phosphenes

(2007) L Cervetto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms of seizure-induced ‘transcriptional channelopathy’ of hyperpolarization-activated cyclic nucleotide gated (HCN) channels

(2007) Cristina Richichi et al.   NEUROBIOLOGY OF DISEASE