Mammalian ABCG-transporters, sterols and lipids: To bind perchance to transport?

ABCG5 and ABCG8 genetic variants in familial hypercholesterolemia

(2020) Laurens F. Reeskamp et al.   Journal of Clinical Lipidology

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened

(2020) Mustafa Yalcinkaya et al.   JOURNAL OF LIPID RESEARCH

Compound Heterozygous Mutations in ABCG5 or ABCG8 Causing Chinese Familial Sitosterolemia

(2020) Weiwei Sun et al.   JOURNAL OF GENE MEDICINE

ABCG2 transports anticancer drugs via a closed-to-open switch

(2020) Benjamin J. Orlando et al.   Nature Communications

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

(2020) Kazi Mirajul Hoque et al.   Nature Communications

Regulation of ABCG4 transporter expression by sterols and LXR ligands

(2020) Alryel Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity

(2020) Narakorn Khunweeraphong et al.   FEBS LETTERS

Post-translational control of the long and winding road to cholesterol

(2020) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization

(2019) Sreevidya Mallappa et al.   MOLECULAR CARCINOGENESIS

Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation

(2019) Matthew McPeek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phosphorylation by protein kinase C stabilizes ABCG1 and increases cholesterol efflux

(2019) Taro Watanabe et al.   JOURNAL OF BIOCHEMISTRY

LncRNA ENST00000602558.1 regulates ABCG1 expression and cholesterol efflux from vascular smooth muscle cells through a p65-dependent pathway

(2019) Can Cai et al.   ATHEROSCLEROSIS

ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer’s disease

(2019) Cinzia Marchi et al.   JOURNAL OF LIPID RESEARCH

The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria

(2019) Pengcheng Wang et al.   Science Advances

ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion

(2019) Aiman A. Zein et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

(2018) Megan H. Cox et al.   BIOCHEMICAL JOURNAL

ABCG5 and ABCG8: more than a defense against xenosterols

(2018) Shailendra B. Patel et al.   JOURNAL OF LIPID RESEARCH

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

(2018) Niall Heyes et al.   DRUG METABOLISM AND DISPOSITION

ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier

(2018) Tuan Minh Do et al.   JOURNAL OF ALZHEIMERS DISEASE

Significance of Cholesterol-Binding Motifs in ABCA1, ABCG1, and SR-B1 Structure

(2018) Alexander D. Dergunov et al.   JOURNAL OF MEMBRANE BIOLOGY

PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes

(2018) Tao Han et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

ABCG1 regulates pulmonary surfactant metabolism in mice and men

(2017) Thomas Q. de Aguiar Vallim et al.   JOURNAL OF LIPID RESEARCH

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity

(2017) John T. Szilagyi et al.   PLACENTA

The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments

(2017) Elvis Pandzic et al.   Scientific Reports

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

(2017) Agnès Dodacki et al.   Scientific Reports

Oxysterols: Old Tale, New Twists

(2016) Winnie Luu et al.   Annual Review of Pharmacology and Toxicology

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in MiceHighlights

(2016) Marit Westerterp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The multidrug transporter ABCG2: still more questions than answers

(2016) A. J. Horsey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular mechanisms of protein-cholesterol interactions in plasma membranes: Functional distinction between topological (tilted) and consensus (CARC/CRAC) domains

(2016) Jacques Fantini et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes

(2016) Lan Deng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

MicroRNA-463-3p/ABCG4: A new axis in glucose-stimulated insulin secretion

(2016) Xuwei Hou et al.   Obesity

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production

(2016) Osamu Sano et al.   PLoS One

Functional Cooperativity between ABCG4 and ABCG1 Isoforms

(2016) Zoltán Hegyi et al.   PLoS One

Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter

(2015) Zita Gál et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain

(2015) Laura J. Sharpe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Frequent down-regulation of ABC transporter genes in prostate cancer

(2015) Rita Demidenko et al.   BMC CANCER

Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8

(2015) Yasuhiro Yamazaki et al.   HEPATOLOGY

The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters

(2015) Shereen M. Aleidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

(2015) Hao Wei et al.   JOURNAL OF LIPID RESEARCH

The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1

(2015) Begum G. Akkaya et al.   MOLECULAR MEMBRANE BIOLOGY

High ABCG4 Expression Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer Patients Treated with Cisplatin-Based Chemotherapy

(2015) Guang Yang et al.   PLoS One

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity

(2015) Duygu Sag et al.   Nature Communications

Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

(2014) Qingcheng Mao et al.   AAPS Journal

Coenzyme Q10 Promotes Macrophage Cholesterol Efflux by Regulation of the Activator Protein-1/miR-378/ATP-Binding Cassette Transporter G1–Signaling Pathway

(2014) Dongliang Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency

(2014) Thomas Engel et al.   ATHEROSCLEROSIS

Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

(2014) M. Ríos et al.   EUROPEAN JOURNAL OF CANCER

Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1

(2014) Victar Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for ABCG1 in Macrophage Inflammation and Lung Homeostasis

(2014) A. J. Wojcik et al.   JOURNAL OF IMMUNOLOGY

Loss of ABCG1 Results in Chronic Pulmonary Inflammation

(2014) A. Baldan et al.   JOURNAL OF IMMUNOLOGY

Relative roles ofABCG5/ABCG8in liver and intestine

(2014) Jin Wang et al.   JOURNAL OF LIPID RESEARCH

A novel mutation ofABCG5gene in a Turkish boy with phytosterolemia presenting with macrotrombocytopenia and stomatocytosis

(2014) Zühre Kaya et al.   PEDIATRIC BLOOD & CANCER

ABCG1 rs57137919G>A Polymorphism Is Functionally Associated with Varying Gene Expression and Apoptosis of Macrophages

(2014) Fang Liu et al.   PLoS One

Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor

(2013) Su Sun Back et al.   BMB Reports

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

ABCG1-mediated generation of extracellular cholesterol microdomains

(2013) Sebastian R. Freeman et al.   JOURNAL OF LIPID RESEARCH

Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis

(2013) Andrew J Murphy et al.   NATURE MEDICINE

Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis

(2013) Y K Adlakha et al.   Cell Death & Disease

Human ATP–Binding Cassette G1 Controls Macrophage Lipoprotein Lipase Bioavailability and Promotes Foam Cell Formation

(2012) Maryline Olivier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function

(2012) Vicky Burns et al.   ATHEROSCLEROSIS

Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein

(2012) Ágnes Telbisz et al.   BIOCHEMICAL JOURNAL

Progesterone receptor downregulates breast cancer resistance protein expression via binding to the progesterone response element in breast cancer

(2012) Xiaojuan Wu et al.   CANCER SCIENCE

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

Protein kinase A modulates the activity of a major human isoform of ABCG1

(2012) Ingrid C. Gelissen et al.   JOURNAL OF LIPID RESEARCH

ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin

(2012) Hiroshi Hirayama et al.   JOURNAL OF LIPID RESEARCH

A Phytosterolemia Patient Presenting Exclusively with Macrothrombocytopenia and Stomatocytic Hemolysis

(2011) Gaifeng Wang et al.   ACTA HAEMATOLOGICA

Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: Findings from in vitro and ex vivo studies

(2011) Hideki Ozasa et al.   ATHEROSCLEROSIS

Calpain-mediated cleavage negatively regulates the expression level of ABCG1

(2011) Natsuki Hori et al.   ATHEROSCLEROSIS

A polymorphism in the ABCG1 promoter is functionally associated with coronary artery disease in a Chinese Han population

(2011) Yan Xu et al.   ATHEROSCLEROSIS

The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

(2011) Illiana Meurs et al.   ATHEROSCLEROSIS

Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice

(2011) Kimberly A. Edgel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

(2011) Elizabeth J. Tarling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Liver X receptors regulate cholesterol homeostasis in oligodendrocytes

(2011) Katherine Nelissen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Adenosine Monophosphate Activated Protein Kinase Regulates ABCG1-Mediated Oxysterol Efflux From Endothelial Cells and Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction

(2010) Dan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Atherosclerosis in Mice With Vascular ATP-Binding Cassette Transporter G1 Deficiency—Brief Report

(2010) Marit Westerterp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired Development of Atherosclerosis in Abcg1 −/− Apoe −/− Mice

(2010) Elizabeth J. Tarling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The ABCG family of membrane-associated transporters: you don't have to be big to be mighty

(2010) Ian D Kerr et al.   BRITISH JOURNAL OF PHARMACOLOGY

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis

(2010) Lily Jakulj et al.   JOURNAL OF LIPID RESEARCH

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

Expression and stability of two isoforms of ABCG1 in human vascular cells

(2009) Ingrid C. Gelissen et al.   ATHEROSCLEROSIS

Human Endothelial Cells of the Placental Barrier Efficiently Deliver Cholesterol to the Fetal Circulation via ABCA1 and ABCG1

(2009) Jasminka Stefulj et al.   CIRCULATION RESEARCH

Murine 12/15-Lipoxygenase Regulates ATP-binding Cassette Transporter G1 Protein Degradation through p38- and JNK2-dependent Pathways

(2009) Melissa H. Nagelin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression and function of ABCG1 and ABCG4 during development and aging

(2009) D. D. Bojanic et al.   JOURNAL OF LIPID RESEARCH

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

(2009) Pamela F Parkinson et al.   Lipids in Health and Disease

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Human ABCG1 Does Not Affect Atherosclerosis in Fat-Fed ApoE-Deficient Mice

(2008) Braydon Burgess et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional ABCG1 expression induces apoptosis in macrophages and other cell types

(2008) László Seres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain

(2008) Yoshinari Uehara et al.   BRAIN RESEARCH

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases

(2008) Masako Togo et al.   CLINICA CHIMICA ACTA

ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet

(2008) Naoki Terasaka et al.   JOURNAL OF CLINICAL INVESTIGATION

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

(2008) Braydon L. Burgess et al.   JOURNAL OF LIPID RESEARCH

Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels

(2007) Ruud Out et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

(2007) Nan Wang et al.   FASEB JOURNAL