Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Article
Hematology
George E. G. Kluck, Alexander S. Qian, Emmanuel H. Sakarya, Henry Quach, Yak D. Deng, Bernardo L. Trigatti
Summary: Atherosclerosis is a chronic disease that affects the artery wall and is a major contributor to cardiovascular diseases. Necrotic cores, which contain debris from dead macrophages, increase the risk of plaque rupture and thrombus formation. HDL (high-density lipoprotein) has direct protective effects on different cells within atherosclerotic plaques, but its role in protecting against necroptosis and necrotic core formation is not fully understood.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Minwoo Lee, Jae-Sung Lim, Yerim Kim, Soo Hyun Park, Sang-Hwa Lee, Chulho Kim, Byung-Chul Lee, Kyung-Ho Yu, Jae-Jun Lee, Mi Sun Oh
Summary: The ApoB/ApoA-I ratio in the acute stage of stroke independently predicts the development of post-stroke cognitive impairment (PSCI) at 3-6 months after stroke due to large artery atherosclerosis. Specifically, a high ApoB/ApoA-I ratio is associated with dysfunction in the frontal domain.
Article
Medicine, Research & Experimental
Matheus Mulling dos Santos, Alessandro de Souza Prestes, Gabriel Teixeira de Macedo, Sabrina Antunes Ferreira, Joao Luis Souza Vargas, Luana Caroline Schuler, Andreza Fabro de Bem, Nilda de Vargas Barbosa
Summary: Syzigium cumini leaf extract (ScExt) has shown to protect macrophages from oxLDL-mediated toxicity by preventing overproduction of reactive oxygen/nitrogen species and foam cell formation induced by oxLDL. These protective effects make ScExt a promising antioxidant for future trials in atherosclerosis prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: The incorporation of SAA in rHDL impairs the structural stability of apoA-I and exacerbates glycation of HDL and apoA-I.
Article
Biochemistry & Molecular Biology
Elena Grao-Cruces, Alejandro Santos-Mejias, Ignacio Ortea, Elvira Marquez-Paradas, Maria E. Martin, Sergio Barrientos-Trigo, Beatriz Bermudez, Sergio Montserrat-de la Paz
Summary: This research aimed to study the protein composition of high-density lipoproteins (HDL) associated with postprandial hyperlipidemia. The results showed that compared to baseline, the expression of APOM, APOE, APOB, and APOA2 in HDL proteins was significantly altered in postprandial hyperlipidemia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu
Summary: Despite advancements in pharmacotherapy and intervention devices, residual cardiovascular risks remain a significant burden on public health. Molecular modifications of lipid and lipoprotein components play a critical role in atherogenicity, with levels of certain lipids and proteins closely associated with atherosclerotic cardiovascular disease. Therapies targeting these modifications are showing promising results in trials for reducing risks and enhancing cardiovascular health.
Article
Nanoscience & Nanotechnology
Wenmin Yuan, Kelsey Ernst, Rui Kuai, Emily E. Morin, Minzhi Yu, Denis O. Sviridov, Jie Tang, Ling Mei, Dan Li, Rose Ackermann, Alan T. Remaley, Anna Schwendeman
Summary: Synthetic high-density lipoproteins nanomedicine (sHDL) composed of ApoA-I mimetic peptides and lipids have shown promising results for the treatment of cardiovascular diseases. However, the understanding of how ApoA-I mimetic peptides affect the properties of sHDL and their relationship with potency is limited. This study evaluated different ApoA-I mimetic peptides in terms of their physical/chemical properties, cholesterol efflux, cholesterol esterification, remodeling, and pharmacokinetics/pharmacodynamics, highlighting the importance of considering overall performance for designing and optimizing ApoA-I mimetic peptides.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Chao Li, Yanli Zhang, Lerong Mei, Aoming Jin, Xueli Cai, Yuesong Pan, Jing Jing, Suying Wang, Xia Meng, Shan Li, Mengxing Wang, Tiemin Wei, Yongjun Wang, Rui Chen, Yu Tian
Summary: Discordantly high Apo B with LDL-C or Non-HDL-C is associated with an increased odds of the presence and burden of intra-/extra-cranial atherosclerotic plaques.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Cell Biology
Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau
Summary: Siglec-E deficiency accelerates the development of atherosclerosis by promoting foam cell formation, potentially through its interaction with CD36 to inhibit foam cell formation. The research findings support the protective role of Siglec-E in atherosclerosis.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Alexander Sorokin, Christin G. Hong, Angel M. Aponte, Elizabeth M. Florida, Jingrong Tang, Nidhi Patel, Irina N. Baranova, Haiou Li, Philip M. Parel, Vicky Chen, Sierra R. Wilson, Emily L. Ongstad, Anna Collen, Martin P. Playford, Thomas L. Eggerman, Marcus Y. Chen, Kazuhiko Kotani, Alexander Bocharov, Alan T. Remaley
Summary: In this study, we found that oxidized apolipoprotein B and oxidized ApoA-I are associated with high-risk coronary plaque features and progression in patients with cardiovascular disease.
Review
Hematology
Hong Y. Choi, Iulia Iatan, Isabelle Ruel, Leslie Brown, Lindsay Hales, Shiwon Choi, Jacques Genest
Summary: The identification of DSC1 as a negative regulator of HDL biogenesis has led to a reconsideration of the hypothesis that HDL biogenesis reduces atherosclerosis. DSC1, which can be targeted by the drug docetaxel, has shown to promote HDL biogenesis and inhibit atherogenic proliferation of vascular smooth muscle cells. Animal studies have demonstrated that docetaxel reduces dyslipidemia-induced atherosclerosis, highlighting the importance of DSC1 as a potential target for HDL biogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Eftaxia-Konstantina Valanti, Katerina Dalakoura-Karagkouni, Panagiotis Fotakis, Elizabeth Vafiadaki, Christos S. Mantzoros, Angeliki Chroni, Vassilis Zannis, Dimitris Kardassis, Despina Sanoudou
Summary: rHDL-apoE3 demonstrates the potential to enhance endothelial cell migration, mainly through the activation of ID1, MEK1/2, and P13K pathways. This therapeutic approach has the potential to promote endothelial regeneration and halt the progression of atherosclerosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Immunology
Glautemberg de Almeida Viana, Mac Dionys Rodrigues da Costa, Mateus Edson da Silva, Bruna Ribeiro Duque, Erlania Alves de Siqueira, Alice Maria Costa Martins, Renata de Sousa Alves, Ramon Roseo Paula Pessao Bezerra de Menezes, Maria Goretti Rodrigues de Queiroz, Tiago Lima Sampaio
Summary: COVID-19 is an inflammatory disease associated with cardiovascular risk, and it may cause changes in lipoprotein metabolism. This study evaluated the association of IL-18 levels and its SNP rs187238 with changes in lipoprotein profiles in COVID-19 outpatients. The results showed that COVID-19 patients had lower levels of total cholesterol and HDL-c, but no difference in IL-18 levels. IL-18 was negatively correlated with HDL-c and positively correlated with the Apo B/Apo A-I ratio. In conclusion, IL-18 levels and its SNP rs187238 were associated with decreased HDL-c and Apo A-I in COVID-19 outpatients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mark Trinder, Yanan Wang, Christian M. Madsen, Tatjana Ponomarev, Lubos Bohunek, Brendan A. Daisely, HyeJin Julia Kong, Lisanne L. Blauw, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Mark M. Wurfel, James A. Russell, Keith R. Walley, Patrick C. N. Rensen, John H. Boyd, Liam R. Brunham
Summary: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.
Editorial Material
Biochemistry & Molecular Biology
Prashant Rai, Michael B. Fessler
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wan-Chi Lin, Michael B. Fessler
Summary: Neutrophils, key effector cells of the innate immune system, have unique interactions with the lung during infection. While their recruitment is essential for pathogen killing, excessive neutrophil trafficking to the lung can lead to tissue injury, underlying various lung diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Infectious Diseases
Tiffany R. Butterfield, Alrica Bruce-Mowatt, Yakima Z. R. Phillips, Nicole Brown, Keisha Francis, Jabari Brown, Jerome P. Walker, Niel A. L. McKnight, Kelvin Ehikhametalor, Devon K. Taylor, Carl A. Bruce, Donovan McGrowder, Gilian Wharfe, Simone L. Sandiford, Tamara K. Thompson, Joshua J. Anzinger
Summary: The performance of various SARS-CoV-2 tests in Jamaica showed comparable diagnostic sensitivities and specificities, with better results for moderate to critical cases. However, these tests have limited utility for asymptomatic and mild infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Francisco Averhoff, Michael Berg, Mary Rodgers, Saladin Osmanov, Xinxin Luo, Mark Anderson, Todd Meyer, Alan Landay, Amiran Gamkrelidze, Esper G. Kallas, Karl Ciuoderis, Juan Pablo Hernandez, Jean Hugues Henry, Jorge Osorio, John Lindo, Johnson Deshommes, Joshua Anzinger, Justen Manasa, Maia Alkashvili, Mboup Souleyman, Pontiano Kaleebu, Rodrigo Correa-Oliveira, Sunil Solomon, Tulio de Olivera, Yupin Suputtamongkol, Gavin Cloherty
Summary: Detection and epidemiologic characterization of infectious disease outbreaks are crucial for early identification and response to potential pandemics. The Abbott Pandemic Defense Coalition (APDC) is a global partnership focused on early detection and mitigation of infectious disease threats.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Suzette M. Cameron-McDermott, Geoffrey J. Barrow, Alicia M. Webster, Carrington O. De La Haye, Denise H. E. Wood, Violet M. Lewis, Alison Nicholson, Glendee Y. Reynolds-Campbell, Camille-Ann A. Thoms-Rodriguez, Karen J. Roye-Green, Nakeisha Otto-Stewart, Zahra N. Miller, Jennifer A. Tomlinson, Nicola Skyers, Magnus Unemo, Joshua J. Anzinger
Summary: This study quantitatively determined the antimicrobial susceptibility of clinical Neisseria gonorrhoeae isolates from men in Jamaica, with findings indicating that ceftriaxone remains effective for treatment but tetracycline and benzylpenicillin show higher resistance levels. Surveillance of N. gonorrhoeae antimicrobial resistance should be expanded in Jamaica and other Caribbean countries to develop evidence-based treatment guidelines.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Ynolde E. Leys, Magdalene Nwokocha, Jerome P. Walker, Tiffany R. Butterfield, Velesha D. Frater, Tamara K. Thompson, Mark Anderson, Gavin A. Cloherty, Joshua J. Anzinger
Summary: This study examined the antibody response and side effects after AstraZeneca COVID-19 vaccination in the Caribbean region, providing evidence for its safe and effective use in vaccination programs.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Tiffany R. Butterfield, David B. Hanna, Robert C. Kaplan, Xiaonan Xue, Jorge R. Kizer, Helen G. Durkin, Seble G. Kassaye, Marek Nowicki, Phyllis C. Tien, Elizabeth T. Topper, Michelle A. Floris-Moore, Kehmia Titanji, Margaret A. Fischl, Sonya Heath, Clovis S. Palmer, Alan L. Landay, Joshua J. Anzinger
Summary: This study investigated the glucose metabolism of CD4(+) T cells in HIV-positive women with and without diabetes mellitus. The results showed that HIV-positive women with diabetes mellitus had elevated CD4(+) T cell glucose metabolism, and treatment of diabetes mellitus may partially correct CD4(+) T cell metabolic dysfunction.
Article
Medicine, General & Internal
Aileen May Lue, Michelle-Ann Elizabeth Hue Richards-Dawson, Georgiana Marie Gordon-Strachan, Syed Matthew Kodilinye, Jacqueline Anne Theresa Dunkley-Thompson, Tracia Dahlia James-Powell, Curtis Alphonso Pryce, Chadwic De'sean Mears, Joshua James Anzinger, Karen Webster-Kerr, Celia Dana Claire Christie
Summary: In 2019, Jamaica experienced its largest dengue outbreak in 40 years, following previous epidemics of Zika virus and Chikungunya. The outbreak mainly affected children aged 1-10 years, and severe dengue resulted in a high mortality rate.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Crista-Lee Shahine Berry, Roxanne Helene Melbourne-Chambers, Abigail Natalie Harrison, Joshua James Anzinger, Kelly-Ann Maxorinthia Gordon-Johnson, Varough Mohamed Deyde, Celia Dana Claire Christie
Summary: This study described pediatric COVID-19 situation in a developing country within the Caribbean. Most infected children had mild symptoms, while MIS-C patients showed more organ involvement and abnormal inflammatory biomarkers, with minimal critical care interventions and excellent outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Review
Virology
Inshan Ali, Pedro M. Alarcon-Elbal, Marcia Mundle, Simmoy A. A. Noble, Chris A. L. Oura, Joshua J. Anzinger, Simone L. Sandiford
Summary: The Caribbean is known both for being a popular tourist destination and a hotspot for arboviruses. With the effects of global warming and expanding vectors, it is important to understand lesser-known arboviruses and the factors that influence their emergence and resurgence. Unfortunately, the literature on Caribbean arboviruses is scattered, difficult to access, and often outdated. In this study, we focus on the lesser-known arboviruses of the insular Caribbean, analyzing their presence and identifying the drivers behind their emergence and resurgence.
Article
Infectious Diseases
Joshua J. Anzinger, Suzette M. Cameron-McDermott, Yakima Z. R. Phillips, Leshawn Mendoza, Mark Anderson, Gavin Cloherty, Susan Strachan-Johnson, John F. Lindo, J. Peter Figueroa
Summary: A serosurvey conducted in Jamaica after the Omicron surge revealed extensive SARS-CoV-2 population immunity, with a significant portion of the population lacking spike RBD IgG antibodies. The study highlights the need to increase COVID-19 vaccine coverage in Jamaica.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2022)
Letter
Immunology
Joshua J. Anzinger
EMERGING INFECTIOUS DISEASES
(2022)
Letter
Immunology
Joshua J. Anzinger, Chadwic D. Mears, A. E. Ades, Keisha Francis, Yakima Phillips, Ynolde E. Leys, Moira J. Spyer, David Brown, Ana M. Bispo de Filippis, Eleni Nastouli, Thomas Byrne, Heather Bailey, Paulette Palmer, Lenroy Bryan, Karen Webster-Kerr, Carlo Giaquinto, Claire Thorne, Celia D. C. Christie, Brittiana Brown, Leroy Campbell, Carla Giaquinto, Georgiana Gordon-Strachan, Marlyn Grindley, Donna Kamicka, Clayton Kelly, John Lindo, Paul Mitchell, Orville Morgan, Alexander Onyonyor, Russell Pierre, Amanda Rousseau, Sofier Scott
Summary: To determine the extent of exposure to Zika virus (ZIKV) and chikungunya virus (CHIKV) in Jamaica, serum samples from 584 pregnant women were collected during 2017-2019. The results showed that 15.6% had antibodies against ZIKV and 83.6% against CHIKV. These findings suggest a potential recirculation of ZIKV in the near future, but not CHIKV.
EMERGING INFECTIOUS DISEASES
(2022)
Meeting Abstract
Pediatrics
Crista-Lee S. Berry, Roxanne Melbourne-Chambers, Abigail Harrison, Joshua Anzinger, Kelly-Ann Gordon-Johnson, Varough Deyde, Celia D. Christie
Article
Medicine, Research & Experimental
Hong Li, J. Alyce Bradbury, Matthew L. Edin, Joan P. Graves, Artiom Gruzdev, Jennifer Cheng, Samantha L. Hoopes, Laura M. DeGraff, Michael B. Fessler, Stavros Garantziotis, Shepherd H. Schurman, Darryl C. Zeldin
Summary: EETs have been shown to reduce macrophage activation and phagocytosis of Streptococcus pneumoniae by downregulating TLR2 and PGLYRP1 expression. Ephx2(-/-) mice had impaired lung bacterial clearance and reduced phagocytosis by macrophages.
JOURNAL OF CLINICAL INVESTIGATION
(2021)