Microdroplet Ultrafast Reactions Speed Antibody Characterization

Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry

(2020) Xiaoqin Zhong et al.   Nature Communications

Rapid and Simultaneous Characterization of Drug Conjugation in Heavy and Light Chains of a Monoclonal Antibody Revealed by High-Resolution Ion Mobility Separations in SLIM

(2020) Gabe Nagy et al.   ANALYTICAL CHEMISTRY

Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments

(2020) Zhenwei Wei et al.   Annual Review of Physical Chemistry

Simple model for the electric field and spatial distribution of ions in a microdroplet

(2020) Christian F. Chamberlayne et al.   JOURNAL OF CHEMICAL PHYSICS

Quantum Mechanical Modeling of Reaction Rate Acceleration in Microdroplets

(2020) Namita Narendra et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Ultrasonic-Based Filter Aided Sample Preparation as the General Method to Sample Preparation in Proteomics

(2020) Luís B. Carvalho et al.   ANALYTICAL CHEMISTRY

Top-Down Characterization of an Intact Monoclonal Antibody Using Activated Ion Electron Transfer Dissociation

(2020) Jean M. Lodge et al.   ANALYTICAL CHEMISTRY

Accelerating Electrochemical Reactions in a Voltage‐Controlled Interfacial Microreactor

(2020) Heyong Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction acceleration at air-solution interfaces: Anisotropic rate constants for Katritzky transamination

(2020) Yangjie Li et al.   JOURNAL OF MASS SPECTROMETRY

A Novel Combined Microstrip Resonator/Nanospray Ionization Source for Microwave-Assisted Trypsin Digestion of Proteins

(2020) Maria E. Rivera-Albarran et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Accelerated Forced Degradation of Therapeutic Peptides in Levitated Microdroplets

(2020) Yangjie Li et al.   PHARMACEUTICAL RESEARCH

Strong Concentration Enhancement of Molecules at the Interface of Aqueous Microdroplets

(2020) Hanqing Xiong et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effects of Weak Electrolytes on Electric Double Layer Ion Distributions

(2020) Christian F. Chamberlayne et al.   Journal of Physical Chemistry Letters

Strong Electric Field Observed at the Interface of Aqueous Microdroplets

(2020) Hanqing Xiong et al.   Journal of Physical Chemistry Letters

Future perspectives of therapeutic monoclonal antibodies

(2019) Kanta Tsumoto et al.   Immunotherapy

LC-MS bioanalysis of intact proteins and peptides

(2019) Lijuan Kang et al.   BIOMEDICAL CHROMATOGRAPHY

Micrometer-Sized Water Droplets Induce Spontaneous Reduction

(2019) Jae Kyoo Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

(2019) Daniel P. Donnelly et al.   NATURE METHODS

Reaction Acceleration in Electrospray Droplets: Size, Distance, and Surfactant Effects

(2019) Brett M. Marsh et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Spontaneous generation of hydrogen peroxide from aqueous microdroplets

(2019) Jae Kyoo Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On-Demand Electrochemical Epoxidation in Nano-Electrospray Ionization Mass Spectrometry to Locate Carbon-Carbon Double Bonds

(2019) Shuli Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gibbs Free Energy and Reaction Rate Acceleration in and on Microdroplets

(2019) Adrian F Tuck   Entropy

Droplet Imbibition Enables Nonequilibrium Interfacial Reactions in Charged Microdroplets

(2019) Taghi Sahraeian et al.   LANGMUIR

Chemoselective N-Alkylation of Indoles in Aqueous Microdroplets

(2019) Elumalai Gnanamani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibodies to watch in 2020

(2019) Hélène Kaplon et al.   mAbs

Development of an LC-MS/MS peptide mapping protocol for the NISTmAb

(2018) Trina Mouchahoir et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enhancement of reaction rate in small-sized droplets: A combined analytical and simulation study

(2018) Sayantan Mondal et al.   JOURNAL OF CHEMICAL PHYSICS

Fluorescence Polarization Anisotropy in Microdroplets

(2018) Zhenpeng Zhou et al.   Journal of Physical Chemistry Letters

Spontaneous formation of gold nanostructures in aqueous microdroplets

(2018) Jae Kyoo Lee et al.   Nature Communications

Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry

(2018) Yutong Jin et al.   mAbs

Glycation of antibodies: Modification, methods and potential effects on biological functions

(2017) Bingchuan Wei et al.   mAbs

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

Abiotic production of sugar phosphates and uridine ribonucleoside in aqueous microdroplets

(2017) Inho Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organic Reactions in Microdroplets: Reaction Acceleration Revealed by Mass Spectrometry

(2016) Xin Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Role of the Interface in Thin Film and Droplet Accelerated Reactions Studied by Competitive Substituent Effects

(2016) Yafeng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advancing pharmaceutical quality: An overview of science and research in the U.S. FDA’s Office of Pharmaceutical Quality

(2016) Adam C. Fisher et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein Biopharmaceuticals

(2015) Szabolcs Fekete et al.   ANALYTICAL CHEMISTRY

Syntheses of Isoquinoline and Substituted Quinolines in Charged Microdroplets

(2015) Shibdas Banerjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microdroplet fusion mass spectrometry for fast reaction kinetics

(2015) Jae Kyoo Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new tool for monoclonal antibody analysis

(2014) Yan An et al.   mAbs

Beyond the flask: Reactions on the fly in ambient mass spectrometry

(2014) Ryan D. Espy et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Characterization of Therapeutic Antibodies and Related Products

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Rapid Online Nonenzymatic Protein Digestion Combining Microwave Heating Acid Hydrolysis and Electrochemical Oxidation

(2010) Franco Basile et al.   ANALYTICAL CHEMISTRY

Sensitive Detection of Native Proteins Using Extractive Electrospray Ionization Mass Spectrometry

(2010) Huanwen Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accelerated bimolecular reactions in microdroplets studied by desorption electrospray ionization mass spectrometry

(2010) Marion Girod et al.   Chemical Science

What can we learn from ambient ionization techniques?

(2009) Huanwen Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Enhanced Protein Digestion through the Confinement of Nanozeolite-Assembled Microchip Reactors

(2008) Ji et al.   ANALYTICAL CHEMISTRY

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine

Direct analysis of liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS)

(2008) Zhixin Miao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

(2007) Cynthia Quan et al.   ANALYTICAL BIOCHEMISTRY