Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

(2018) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Antibodies to watch in 2018

(2018) Hélène Kaplon et al.   mAbs

Erratum to: Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

(2017) Lidong He et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins

(2017) Weichen Xu et al.   mAbs

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of Therapeutic Monoclonal Antibodies at the Subunit-Level using Middle-Down 193 nm Ultraviolet Photodissociation

(2016) Victoria C. Cotham et al.   ANALYTICAL CHEMISTRY

Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics

(2016) Yutong Jin et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Comprehensive glycosylation profiling of IgG and IgG-fusion proteins by top-down MS with multiple fragmentation techniques

(2016) Bao Quoc Tran et al.   Journal of Proteomics

A Retrospective Evaluation of the Use of Mass Spectrometry in FDA Biologics License Applications

(2016) Sarah Rogstad et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Characterization of acidic and basic variants of IgG1 therapeutic monoclonal antibodies based on non-denaturing IEF fractionation

(2015) Oluwatosin O. Dada et al.   ELECTROPHORESIS

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies

(2015) Alain Beck et al.   JOURNAL OF MASS SPECTROMETRY

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

(2015) Richard S Rogers et al.   mAbs

MASH Suite Pro: A Comprehensive Software Tool for Top-Down Proteomics

(2015) Wenxuan Cai et al.   MOLECULAR & CELLULAR PROTEOMICS

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

(2014) Luca Fornelli et al.   ANALYTICAL CHEMISTRY

Structural Analysis of an Intact Monoclonal Antibody by Online Electrochemical Reduction of Disulfide Bonds and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2014) Simone Nicolardi et al.   ANALYTICAL CHEMISTRY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry

(2013) Yuan Mao et al.   ANALYTICAL CHEMISTRY

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

(2013) Hao Zhang et al.   FEBS LETTERS

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

A Platform for Characterizing Therapeutic Monoclonal Antibody Breakdown Products by 2D Chromatography and Top-Down Mass Spectrometry

(2012) Matthew T. Mazur et al.   AAPS Journal

Characterization of Therapeutic Antibodies and Related Products

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

(2012) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

C-terminal modification of monoclonal antibody drugs: Amidated species as a general product-related substance

(2012) Masahiro Tsubaki et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Characterization of the basic charge variants of a human IgG1

(2012) Timothy Kaschak et al.   mAbs

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS

(2012) Luca Fornelli et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

(2011) Yury O. Tsybin et al.   ANALYTICAL CHEMISTRY

Unit Mass Baseline Resolution for an Intact 148 kDa Therapeutic Monoclonal Antibody by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2011) Santosh G. Valeja et al.   ANALYTICAL CHEMISTRY

Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics

(2011) Igor A. Kaltashov et al.   BIOTECHNOLOGY ADVANCES

High-Throughput Middle-Down Analysis Using an Orbitrap

(2010) Joe Cannon et al.   JOURNAL OF PROTEOME RESEARCH

Probing deamidation in therapeutic immunoglobulin gamma (IgG1) by ‘bottom-up’ mass spectrometry with electron transfer dissociation

(2010) Raju Mukherjee et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

An improved trypsin digestion method minimizes digestion-induced modifications on proteins

(2009) Da Ren et al.   ANALYTICAL BIOCHEMISTRY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mass spectrometry for structural characterization of therapeutic antibodies

(2008) Zhongqi Zhang et al.   MASS SPECTROMETRY REVIEWS

Precision proteomics: The case for high resolution and high mass accuracy

(2008) M. Mann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES