Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non‐Viral Polymeric Vectors for Pulmonary Fibrosis Therapy

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Improved Prognosis in Cystic Fibrosis: Consideration for Intensive Care during the COVID-19 Pandemic

(2020) Kathleen J. Ramos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COVID-19, Arrhythmic Risk and Inflammation: Mind the Gap!

(2020) Pietro Enea Lazzerini et al.   CIRCULATION

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Progress in Understanding and Treating Idiopathic Pulmonary Fibrosis

(2019) Jonathan A. Kropski et al.   Annual Review of Medicine

The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis

(2019) Honghui Cao et al.   LABORATORY INVESTIGATION

Mechanisms, Applications, and Challenges of Insect RNA Interference

(2019) Kun Yan Zhu et al.   Annual Review of Entomology

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

(2018) Rafael Kramann et al.   BLOOD

Effect of PEI surface modification with PEG on cytotoxicity and transfection efficiency

(2018) Batoul Saqafi et al.   Micro & Nano Letters

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis

(2018) Xiang Chen et al.   Cell Death & Disease

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions

(2018) Zhijia Tan et al.   PLoS Genetics

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

(2018) Jiwei Hou et al.   Cell Communication and Signaling

TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis

(2017) Jiwei Hou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

(2017) Daisy Y. Shu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

In vitro toxicity assessment of oral nanocarriers

(2016) Silvia Gabriella Ciappellano et al.   ADVANCED DRUG DELIVERY REVIEWS

Technological development of structural DNA/RNA-based RNAi systems and their applications

(2016) Eun Hye Jeong et al.   ADVANCED DRUG DELIVERY REVIEWS

Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics

(2016) Soo Hyeon Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

(2016) Rafael Kramann et al.   Cell Stem Cell

Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers

(2016) Kotaro Hayashi et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Polyethylenimine: A versatile, multifunctional non-viral vector for nucleic acid delivery

(2016) Abhijeet P. Pandey et al.   Materials Science & Engineering C-Materials for Biological Applications

Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways

(2016) Christopher M. Evans et al.   PHYSIOLOGICAL REVIEWS

miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis

(2016) Cong Wang et al.   Scientific Reports

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Role of Wnt/β-Catenin Signaling in Epithelial Differentiation of Lung Resident Mesenchymal Stem Cells

(2015) Chaowen Shi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis

(2015) Marek Barczyk et al.   Stem Cell Reviews and Reports

Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis

(2015) Marek Barczyk et al.   Stem Cell Reviews and Reports

Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells

(2014) Kristen L. Kozielski et al.   ACS Nano

Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles

(2014) Hyun Jin Kim et al.   ACS Nano

Targeting the Hedgehog–Glioma-Associated Oncogene Homolog Pathway Inhibits Bleomycin-Induced Lung Fibrosis in Mice

(2014) Elika Farrokhi Moshai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Isolation and characterization of lung resident mesenchymal stem cells capable of differentiating into alveolar epithelial type II cells

(2014) Xuemin Gong et al.   CELL BIOLOGY INTERNATIONAL

Development of RNAi technology for targeted therapy — A track of siRNA based agents to RNAi therapeutics

(2014) Yinjian Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Fibrocytes Are Not an Essential Source of Type I Collagen during Lung Fibrosis

(2014) Kathryn R. Kleaveland et al.   JOURNAL OF IMMUNOLOGY

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

(2014) Woosook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNAs in Cancer

(2013) Gianpiero Di Leva et al.   Annual Review of Pathology-Mechanisms of Disease

Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers

(2012) Mengyao Zheng et al.   BIOMATERIALS

Protein-based nanocarriers as promising drug and gene delivery systems

(2012) Ahmed O. Elzoghby et al.   JOURNAL OF CONTROLLED RELEASE

The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism

(2012) Xin Zheng et al.   PLoS One

RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking

(2011) Kathleen J. Haley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Target specific systemic delivery of TGF-β siRNA/(PEI-SS)-g-HA complex for the treatment of liver cirrhosis

(2011) Kitae Park et al.   BIOMATERIALS

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies for treating idiopathic pulmonary fibrosis

(2010) R. M. du Bois   NATURE REVIEWS DRUG DISCOVERY

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Precise measurement of diffusion by multi-color dual-focus fluorescence correlation spectroscopy

(2008) C. B. Müller et al.   EPL

PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy

(2008) Anastasia Malek et al.   JOURNAL OF DRUG TARGETING