Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions

WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice

(2017) Daiei Takahashi et al.   EBioMedicine

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy

(2016) Xinjun He et al.   DEVELOPMENT

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

(2016) Makiko Iwafuchi-Doi et al.   MOLECULAR CELL

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

An Emerging Regulatory Landscape for Skeletal Development

(2016) Hironori Hojo et al.   TRENDS IN GENETICS

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

(2016) Ying Liu et al.   Nature Communications

Systematic Reconstruction of Molecular Cascades Regulating GP Development Using Single-Cell RNA-Seq

(2016) Junxiang Li et al.   Cell Reports

Nosology and classification of genetic skeletal disorders: 2015 revision

(2015) Luisa Bonafe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9

(2015) G. Zhou et al.   DEVELOPMENT

Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?

(2015) Kwok Yeung Tsang et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

SOX9 inhibits  -TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties

(2015) W. Deng et al.   JOURNAL OF CELL SCIENCE

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis

(2015) Chia-Feng Liu et al.   NUCLEIC ACIDS RESEARCH

SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains

(2015) Yong-Heng Huang et al.   Scientific Reports

Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage

(2015) J. Park et al.   Biology Open

WNK4 is the major WNK positively regulating NCC in the mouse kidney

(2014) Daiei Takahashi et al.   BIOSCIENCE REPORTS

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Indian Hedgehog Signaling Regulates Transcription and Expression of Collagen Type X via Runx2/Smads Interactions

(2014) Katsuhiko Amano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sonic Hedgehog Improves Redifferentiation of Dedifferentiated Chondrocytes for Articular Cartilage Repair

(2014) Lin Lin et al.   PLoS One

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Sox proteins: regulators of cell fate specification and differentiation

(2013) Y. Kamachi et al.   DEVELOPMENT

Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers

(2013) A. Jankowski et al.   GENOME RESEARCH

A far-upstream (−70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration

(2013) Timothy J. Mead et al.   NUCLEIC ACIDS RESEARCH

The UCSC Genome Browser database: 2014 update

(2013) Donna Karolchik et al.   NUCLEIC ACIDS RESEARCH

Probing Allostery Through DNA

(2013) S. Kim et al.   SCIENCE

MAML1 Enhances the Transcriptional Activity of Runx2 and Plays a Role in Bone Development

(2013) Takashi Watanabe et al.   PLoS Genetics

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

(2012) E. Metzakopian et al.   DEVELOPMENT

FoxA Family Members Are Crucial Regulators of the Hypertrophic Chondrocyte Differentiation Program

(2012) Andreia Ionescu et al.   DEVELOPMENTAL CELL

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

(2012) K. A. Peterson et al.   GENES & DEVELOPMENT

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors

(2012) J. Wang et al.   GENOME RESEARCH

Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina

(2012) Brian McNeill et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Trps1 and Its Target Gene Sox9 Regulate Epithelial Proliferation in the Developing Hair Follicle and Are Associated with Hypertrichosis

(2012) Katherine A. Fantauzzo et al.   PLoS Genetics

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

(2011) D. Ikegami et al.   DEVELOPMENT

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord

(2011) Owen J. Tamplin et al.   DEVELOPMENTAL BIOLOGY

Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors

(2011) Kunihiko Hiramatsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

(2011) Trevor L. Cameron et al.   PLoS One

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

(2011) Yukio Nakamura et al.   Nature Communications

SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression

(2011) Victor Y. L. Leung et al.   PLoS Genetics

Sterol metabolism and SREBP activation

(2010) Ryuichiro Sato   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Genome-Wide Analyses of Gene Expression during Mouse Endochondral Ossification

(2010) Claudine G. James et al.   PLoS One

Global comparative transcriptome analysis of cartilage formation in vivo

(2009) Trevor L Cameron et al.   BMC DEVELOPMENTAL BIOLOGY

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3

(2009) Manuela Wuelling et al.   DEVELOPMENTAL BIOLOGY

Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-α signalling in endochondral bone growth

(2009) Anita Woods et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sox9 Family Members Negatively Regulate Maturation and Calcification of Chondrocytes through Up-Regulation of Parathyroid Hormone–related Protein

(2009) Katsuhiko Amano et al.   MOLECULAR BIOLOGY OF THE CELL

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Data clustering: 50 years beyond K-means

(2009) Anil K. Jain   PATTERN RECOGNITION LETTERS

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

(2008) S. A. Vokes et al.   GENES & DEVELOPMENT

L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

(2008) Y. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data

(2008) Anton Valouev et al.   NATURE METHODS

Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing

(2008) Elizabeth D. Wederell et al.   NUCLEIC ACIDS RESEARCH