A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors

Effects of Disulfide Bonds on Bindings of Inhibitors to BACE1 Decoded by Multiple Replica Accelerated Molecular Dynamics Simulations

(2020) Jianzhong Chen et al.   ACS Chemical Neuroscience

Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies

(2019) Arun K Ghosh et al.   ChemMedChem

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2

(2019) Kazuki Fujimoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of an efficient enzyme production and structure-based discovery platform for BACE1 inhibitors

(2019) Yu-Chen Yen et al.   BIOCHEMISTRY

Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions

(2019) Jianzhong Chen et al.   ACS Chemical Neuroscience

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

(2016) Ingrid C. Rulifson et al.   PLoS One

Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

(2016) Arun K. Ghosh et al.   Chemical Science

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

(2016) Derya R. Shimshek et al.   Scientific Reports

Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic β-cells

(2015) Gema Alcarraz-Vizán et al.   FASEB JOURNAL

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method

(2014) Hoda Mirsafian et al.   TheScientificWorldJOURNAL

Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones

(2013) David W. Banner et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

(2011) Yechun Xu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

(2011) Daria Esterházy et al.   Cell Metabolism

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of aggregation in protein refolding: The temperature-leap tactic

(2010) Yansheng Xie et al.   PROTEIN SCIENCE

Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors

(2009) Rainer Machauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Large Scale Refolding and Purification of the Catalytic Domain of Human BACE-2 Produced in E. coli

(2009) T. Emmons et al.   PROTEIN AND PEPTIDE LETTERS

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid   Protein Production

(2008) H. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY