Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

(2014) Mark R. Fielden et al.   TOXICOLOGIC PATHOLOGY

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes

(2013) Frauke van Bebber et al.   JOURNAL OF NEUROCHEMISTRY

PMEL: a pigment cell-specific model for functional amyloid formation

(2013) Brenda Watt et al.   Pigment Cell & Melanoma Research

Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMEL

(2013) Lisa S. Andersson et al.   PLoS One

Skin melanocytes: biology and development

(2013) Mirosława Cichorek et al.   Postepy Dermatologii i Alergologii

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

(2013) L. Rochin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction ofMC1RandPMELalleles on solid coat colors in Highland cattle

(2012) Sheila M. Schmutz et al.   ANIMAL GENETICS

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

(2012) Jun Cai et al.   EMBO Molecular Medicine

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation

(2011) Emi K. Nishimura   Pigment Cell & Melanoma Research

Inactivation of Pmel Alters Melanosome Shape But Has Only a Subtle Effect on Visible Pigmentation

(2011) Anders R. Hellström et al.   PLoS Genetics

BACE2 plays a role in the insulin receptor trafficking in pancreatic β-cells

(2010) Silvia Casas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils

(2009) Brenda Watt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BACE1 Structure and Function in Health and Alzheimers Disease

(2008) Sarah Cole et al.   Current Alzheimer Research