Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Generation of an antibody toolbox to characterize hERG

(2012) Georg J. Hausammann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural insights for engineering binding proteins based on non-antibody scaffolds

(2012) Ryan N Gilbreth et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain

(2012) Daniel Schlatter et al.   mAbs

Identification of BACE2 as an avid ß-amyloid-degrading protease

(2012) Samer O Abdul-Hay et al.   Molecular Neurodegeneration

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

(2011) Yechun Xu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

(2011) Daria Esterházy et al.   Cell Metabolism

Nanobody stabilization of G protein-coupled receptor conformational states

(2011) Jan Steyaert et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic  2-microglobulin variant

(2011) K. Domanska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structure of the Neutralizing Llama VHH D7 and Its Mode of HIV-1 gp120 Interaction

(2010) Andreas Hinz et al.   PLoS One

Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1

(2009) Akshaya K. Meher et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

(2009) Konstantin V. Korotkov et al.   STRUCTURE

Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

(2008) Tiago M. Bandeiras et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tyramine fragment binding to BACE-1

(2008) Andreas Kuglstatter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alternative binding proteins: Affibody binding proteins developed from a small three-helix bundle scaffold

(2008) Per-Åke Nygren   FEBS Journal

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

(2008) Anita Y. Lam et al.   JOURNAL OF STRUCTURAL BIOLOGY

Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold

(2008) Valentina Tereshko et al.   PROTEIN SCIENCE

Chaperone-Assisted Crystallography with DARPins

(2008) Gaby Sennhauser et al.   STRUCTURE