Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors
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Title
Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors
Authors
Keywords
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Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 54, Issue 4, Pages 930-939
Publisher
American Chemical Society (ACS)
Online
2021-02-06
DOI
10.1021/acs.accounts.0c00843
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Note: Only part of the references are listed.- Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
- (2021) Jitender Mehla et al. mBio
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- (2020) Paramita Saha et al. ACS Infectious Diseases
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- (2020) Inga V. Leus et al. MOLECULAR MICROBIOLOGY
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- (2020) Lucien Fabre et al. STRUCTURE
- Structural and Functional Diversity of Resistance–Nodulation–Cell Division Transporters
- (2020) Philip A. Klenotic et al. CHEMICAL REVIEWS
- Identification of Binding Sites for Efflux Pump Inhibitors of the Escherichia coli AcrAB-TolC component AcrA
- (2019) Zbigniew M. Darzynkiewicz et al. BIOPHYSICAL JOURNAL
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- (2019) Bing Zhang et al. CELL
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- (2019) Helen I. Zgurskaya et al. Annals of the New York Academy of Sciences
- In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
- (2019) Xiaodong Shi et al. Nature Communications
- The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria
- (2019) Juan Manuel Belardinelli et al. Scientific Reports
- Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane
- (2019) Ganesh Krishnamoorthy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Conformational Dynamics of AcrA Govern Multidrug Efflux Pump Assembly
- (2019) Anthony J. Hazel et al. ACS Infectious Diseases
- AcrB: a mean, keen, drug efflux machine
- (2019) Jessica Kobylka et al. Annals of the New York Academy of Sciences
- Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria
- (2019) Julia Vergalli et al. NATURE REVIEWS MICROBIOLOGY
- The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
- (2018) Michelle F. Richter et al. Annals of the New York Academy of Sciences
- Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii
- (2018) Inga V. Leus et al. JOURNAL OF BACTERIOLOGY
- Immunization with outer membrane proteins (OprF and OprI) and flagellin B protects mice from pulmonary infection with mucoid and nonmucoid Pseudomonas aeruginosa
- (2018) Ramadan Hassan et al. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
- Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier
- (2018) Helen I. Zgurskaya et al. RESEARCH IN MICROBIOLOGY
- Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa
- (2018) Sarah J. Cooper et al. ACS Infectious Diseases
- Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump
- (2017) Zhi Yue et al. Journal of Chemical Theory and Computation
- Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria
- (2017) Ganesh Krishnamoorthy et al. mBio
- An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
- (2017) Zhao Wang et al. eLife
- Kinetic Control of Quorum Sensing in Pseudomonas aeruginosa by Multidrug Efflux Pumps
- (2017) David Wolloscheck et al. ACS Infectious Diseases
- Bifurcation kinetics of drug uptake by Gram-negative bacteria
- (2017) David A. Westfall et al. PLoS One
- Breaking the permeability barrier ofEscherichia coliby controlled hyperporination of the outer membrane.
- (2016) Ganesh Krishnamoorthy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
- (2016) Hanno Sjuts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump
- (2016) Alfred D. Kinana et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump
- (2016) Narges Abdali et al. ACS Infectious Diseases
- Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis
- (2016) Juan Manuel Belardinelli et al. ACS Infectious Diseases
- Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC fromPseudomonas aeruginosa
- (2015) Jon W. Weeks et al. MOLECULAR MICROBIOLOGY
- Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance
- (2014) Jessica MA Blair et al. Future Microbiology
- Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
- (2014) Thomas Eicher et al. eLife
- On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein
- (2013) Ganesh Krishnamoorthy et al. MOLECULAR MICROBIOLOGY
- Structural basis for the inhibition of bacterial multidrug exporters
- (2013) Ryosuke Nakashima et al. NATURE
- Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC
- (2011) Elena B. Tikhonova et al. CHEMISTRY & BIOLOGY
- Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems
- (2010) F. De Angelis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The C-Terminal Domain of AcrA Is Essential for the Assembly and Function of the Multidrug Efflux Pump AcrAB-TolC
- (2009) Q. Ge et al. JOURNAL OF BACTERIOLOGY
- Kinetic control of TolC recruitment by multidrug efflux complexes
- (2009) E. B. Tikhonova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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