Review
Immunology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Hector J. Maldonado-Garza, Elvira Garza-Gonzalez
Summary: Infections caused by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat due to widespread antibiotic resistance. New antibiotics and combinations with existing drugs have shown potential in treating these infections, but there are reports of resistance to these treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Azza Troudi, Jean Michel Bolla, Naouel Klibi, Jean Michel Brunel
Summary: Gram-negative bacteria pose a significant threat to public health due to the spread of drug resistance and the lack of effective alternative treatments. This study presents a promising strategy to combat resistant strains by combining a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative, resulting in a significant decrease in antibiotic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Ze-Hua Cui, Hui-Ling He, Zi-Jian Zheng, Zhao-Qi Yuan, Ying Chen, Xin-Yi Huang, Hao Ren, Yu-Feng Zhou, Dong-Hao Zhao, Liang-Xing Fang, Yang Yu, Ya-Hong Liu, Xiao-Ping Liao, Jian Sun
Summary: Phentolamine enhances the antibacterial activity of macrolide antibiotics against Gram-negative bacteria by reducing efflux pump activity and causing direct damage to the outer membrane leaflet.
Article
Microbiology
Weijie Wang, Xiaoli Zhu, Huan Luo, Zheng Wang, Anjin Hong, Jie Zeng, Li Li, Dai Wang, Xianming Deng, Xilin Zhao
Summary: As the increase in antimicrobial resistance continues, the options for effectively treating multidrug-resistant (MDR) Gram-negative infections are decreasing. Finding ways to enhance the lethality of old agents with unique molecular targets is important, as new antimicrobial development is increasingly difficult. This study showed that the old antibiotic bicyclomycin has good bacteriostatic activity against multiple clinical isolates of MDR Gram-negative pathogens. Additionally, the combination of bicyclomycin with doxycycline showed enhanced efficacy in inhibiting bacterial growth and in vivo killing, suggesting the potential of bicyclomycin-containing regimens as new treatment options for MDR Gram-negative infections caused by specific pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Review
Pharmacology & Pharmacy
Bikash Baral
Summary: The emergence of antibiotic resistance superbugs highlights the urgent need to address the global problem of antibiotic resistance. Among various methods, the development of supplemental therapies for antibiotics, such as bacteriophage therapy, could be a viable infection control option. However, the safe and regulated application of phage treatment requires extensive understanding of the characteristics and behavior of specific phage-bacterium systems. This mini-review provides an overview of the potential and challenges of phage therapy as an accepted infection management strategy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Erlangga Yusuf, Hannelore I. Bax, Nelianne J. Verkaik, Mireille van Westreenen
Summary: Infections in the ICU are often caused by Gram-negative bacteria, which can become resistant to traditional antibiotics, limiting treatment options. In recent years, FDA has approved new antibiotics with predominant activities against Gram-negative bacteria, providing more choices for treatment in specific circumstances.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Christine A. Pybus, Christina Felder-Scott, Victor Obuekwe, David E. Greenberg
Summary: The study compared the antimicrobial activity of Cefiderocol with seven commonly used antibiotics against multidrug-resistant pathogens, finding that Cefiderocol had potent inhibitory effects on biofilms of various pathogens, with consistently lower MIC90 values compared to other antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Qi Zhang, Shang Chen, Xiaojia Liu, Wenhan Lin, Kui Zhu
Summary: The combination of marine antibiotic equisetin and colistin shows a strong synergistic effect against Gram-negative bacteria, especially multi-drug resistant strains. Colistin promotes the intracellular accumulation of equisetin, leading to quick bacteria killing. Equisetin also restores colistin activity in an infection model, providing an alternative approach to combat Gram-negative pathogens in clinics.
Article
Microbiology
Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li
Summary: As multidrug-resistant pathogens emerge and spread rapidly, novel antibiotics are urgently needed. Traditional Chinese medicine, such as baicalein, can be used as an adjuvant to enhance the efficacy of antibiotics. Baicalein was found to potentiate doxycycline against multidrug-resistant Gram-negative pathogens by disrupting the bacterial membrane and enhancing antibiotic entry. It can also increase the production of reactive oxygen species and inhibit multidrug efflux pumps and biofilm formation to potentiate antibiotic efficacy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Walaa K. Mousa, Rose Ghemrawi, Tareq Abu-Izneid, Azza Ramadan, Farah Al-Marzooq
Summary: The human body is a superorganism that contains trillions of microbes, most of which reside in the gut. These microbes have developed strategies to regulate the immune system and maintain intestinal immune homeostasis through the secretion of chemical mediators. Through a combination of experimental and computational methods, researchers have discovered lactomodulin, a unique peptide from Lactobacillus rhamnosus that exhibits dual anti-inflammatory and antibiotic activities with minimal cytotoxicity in human cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Meirong Song, Ying Liu, Tingting Li, Xiaojia Liu, Zhihui Hao, Shuangyang Ding, Pharkphoom Panichayupakaranant, Kui Zhu, Jianzhong Shen
Summary: This study demonstrates the potential of natural flavonoids from plants against multidrug resistant bacteria, with a focus on the structure-activity relationship analysis of two compounds, alpha-mangostin and isobavachalcone. These compounds show rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, and mechanism studies suggest they target bacterial membrane phospholipids. The efficacy of these natural products in infection or contamination models highlights them as a promising and underappreciated resource for combating antibiotic resistance.
Article
Microbiology
Diletta Collalto, Alessandra Fortuna, Paolo Visca, Francesco Imperi, Giordano Rampioni, Livia Leoni
Summary: Co-administration of colistin and clofoctol enhances the bactericidal effect of colistin and reduces the minimum inhibitory concentration (MIC) of colistin in resistant strains. This study suggests the potential development of inhaled clofoctol-colistin formulations for the treatment of difficult-to-treat airway infections caused by drug-resistant Gram-negative pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Tanshi Mehrotra, Dipasri Konar, Agila Kumari Pragasam, Shakti Kumar, Pradipta Jana, Prabhakar Babele, Deepjyoti Paul, Ayushi Purohit, Subhash Tanwar, Susmita Bakshi, Santanu Das, Jyoti Verma, Daizee Talukdar, Lekshmi Narendrakumar, Akanksha Kothidar, Sonali Porey Karmakar, Susmita Chaudhuri, Sujoy Pal, Kajal Jain, Chittur V. Srikanth, M. Jeeva Sankar, Krishnamohan Atmakuri, Ramesh Agarwal, Rajni Gaind, Mamatha Ballal, Nagamani Kammili, Rupak K. Bhadra, Thandavarayan Ramamurthy, G. Balakrish Nair, Bhabatosh Das
Summary: Microbes evolve rapidly through mutations and acquisition of mobile genetic elements (MGEs) associated with fitness traits like antimicrobial resistance (AMR). A multicentric study in India decoded genome sequences of bacterial pathogens causing sepsis, urinary tract infections, and respiratory infections. The study identified pathogen-specific AMR genes (ARGs) and MGEs, and differential abundance of resistance-associated proteins in the presence and absence of antibiotics, providing valuable insights for AMR diagnostics and antimicrobial therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Arianne Lovey, Mila Krel, Allen Borchardt, Thomas Brady, Jason N. Cole, Quyen-Quyen Do, Joanne Fortier, Grayson Hough, Wanlong Jiang, Alain Noncovich, Les Tari, Qiping Zhao, James M. Balkovec, Yanan Zhao, David S. Perlin
Summary: ADCs have the potential to bind strongly to drug-resistant G- pathogens, regardless of lipopolysaccharide modifications, indicating a promising treatment alternative in infections caused by drug-resistant G- bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Medicinal
Min Li, Jialin Li, Jingyi Li, Jie Zhang, Yuqing Zhao, Wenying Li, Yunfei Zhang, Jinrong Hu, Xiaolin Xie, Dezhu Zhang, Han Li, Qianqian Zhao, Hong Gao, Chengyuan Liang
Summary: The emergence of drug-resistant strains presents a challenge for traditional antibiotics. In this study, a collection of pleuromutilin aromatic acrylate derivatives were designed and synthesized to explore novel antibacterial drugs. Most of these derivatives displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria, with 5g showing the strongest activity and potential as a clinical treatment for drug-resistant bacterial infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Fan Liu, Peter M. Wright, Andrew G. Myers
Article
Chemistry, Multidisciplinary
Matthew J. Mitcheltree, Jack W. Stevenson, Amarnath Pisipati, Andrew G. Myers
Summary: A flexible, component-based synthetic route to the amino sugar fragment of lincosamide antibiotics is described, using nitroaldol chemistry and a glycal epoxide as key components; through building-block exchange and late-stage functionalization, this route allows access to a variety of rationally designed lincosamides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Jeremy D. Mason, Daniel W. Terwilliger, Aditya R. Pote, Andrew G. Myers
Summary: A gram-scale synthesis of ibooxycin, an antibiotic candidate with a fused bicyclic amino acid residue, was successfully developed. Key transformations in the route include intramolecular hydrosilylation-oxidation sequence for ring-fusion stereocenters and high-yielding, highly diastereoselective alkylation of a pseudoephenamine amide. This synthetic strategy provided ample quantities of ibooxycin for in vivo profiling in murine models of infection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Kelvin J. Y. Wu, Amy E. Benedetto, Andrew G. Myers
Summary: The regioselectivity of a [3+2] dipolar cycloaddition reaction between a stabilized azomethine ylide and an electron-deficient dipolarophile is contrary to a previous report in this journal.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Matthew T. Peszko, Stuart L. Schreiber, Andrew G. Myers
Summary: This article reveals an error in the mechanism proposed for the transformation of cyclopentanone to the dienoic acid 1, as published in this journal. It is shown that carbon 11 does not derive from dimethyl sulfoxide as proposed, but from the dichloromethane present in the quenching solution. The intermediacy of an alpha-chloromethyl ketone and its subsequent fragmentation in the presence of a hydroxide ion is supported by experiments described herein and by extensive literature precedent.
JOURNAL OF ORGANIC CHEMISTRY
(2023)