Time and Pot Economy in Total Synthesis

Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step

(2020) Seitaro Koshino et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-pot synthesis of chiral cis-hydrindanes via diphenylprolinol silyl ether mediated domino reaction and aldol condensation

(2020) Nariyoshi Umekubo et al.   CHEMISTRY LETTERS

Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde

(2020) Steven H. Bennett et al.   CHEMICAL RECORD

Asymmetric One-Pot Mukaiyama Michael/Michael Reaction Catalyzed by Diphenylprolinol Silyl Ether

(2020) Nariyoshi Umekubo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Time Economy in Total Synthesis

(2020) Yujiro Hayashi   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of a Docosahexaenoic Acid Prostanoid Using an Intramolecular Organocatalytic Michael Reaction of a Formyl-Enal Derivative

(2020) Johanna Revol-Cavalier et al.   ORGANIC LETTERS

Pot-Economical Total Synthesis of Clinprost

(2020) Nariyoshi Umekubo et al.   ORGANIC LETTERS

Asymmetric Synthesis of Biaryl Atropisomers Using an Organocatalyst‐Mediated Domino Reaction as the Key Step

(2019) Yujiro Hayashi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Asymmetric Michael Reaction of α,β-Unsaturated Aldehydes and Ketones Catalyzed by Two Secondary Amine Catalysts

(2018) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantio- and Diastereoselective Synthesis of Latanoprost using an Organocatalyst

(2018) Genki Kawauchi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total synthesis of estradiol methyl ether and its five-pot synthesis through the use of an organocatalyst

(2018) Seitaro Koshino et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recent advances in asymmetric total synthesis of prostaglandins

(2017) Haihui Peng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Total Synthesis of Beraprost Using Organocatalyst

(2017) Shigenobu Umemiya et al.   ORGANIC LETTERS

Time Economical Total Synthesis of (−)-Oseltamivir

(2016) Yujiro Hayashi et al.   ORGANIC LETTERS

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

Multistep Continuous-Flow Synthesis of (–)-Oseltamivir

(2016) Yujiro Hayashi et al.   SYNTHESIS-STUTTGART

Pot economy and one-pot synthesis

(2016) Yujiro Hayashi   Chemical Science

Oxidative Amidation of Nitroalkanes with Amine Nucleophiles using Molecular Oxygen and Iodine

(2015) Jing Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step

(2015) Yujiro Hayashi et al.   ORGANIC LETTERS

Asymmetric Synthesis of Natural Products and Medicinal Drugs through One-Pot-Reaction Strategies

(2015) Bor-Cherng Hong et al.   SYNTHESIS-STUTTGART

Asymmetric Organocatalyzed Michael Addition of Nitromethane to a 2-Oxoindoline-3-ylidene Acetaldehyde and the Three One-Pot Sequential Synthesis of (−)-Horsfiline and (−)-Coerulescine

(2014) Takasuke Mukaiyama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nef Reaction with Molecular Oxygen in the Absence of Metal Additives, and Mechanistic Insights

(2014) Shigenobu Umemiya et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Assembly of Steroidal Tetracyclic Skeletons

(2014) Preeti Gupta et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Diels–Alder Reaction in Steroid Synthesis

(2014) Michael Sherburn et al.   SYNTHESIS-STUTTGART

Pot Economy in the Synthesis of Prostaglandin A1and E1Methyl Esters

(2013) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Formal [3 + 2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol-mediated Domino Aldol–Acetalization Reaction for the Construction of Tetrahydrofuran

(2013) Yujiro Hayashi et al.   CHEMISTRY LETTERS

One-Pot Synthesis of (−)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction

(2013) Takasuke Mukaiyama  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Michael Reaction of Nitroenamine Derivatives with Aldehydes: Short and Efficient Asymmetric Synthesis of (−)-Oseltamivir

(2012) Jiang Weng et al.   ChemCatChem

Stereocontrolled organocatalytic synthesis of prostaglandin PGF2α in seven steps

(2012) Graeme Coulthard et al.   NATURE

Thiol-Free Synthesis of Oseltamivir and Its Analogues via Organocatalytic Michael Additions of Oxyacetaldehydes to 2-Acylaminonitroalkenes

(2012) Július Durmis et al.   SYNTHESIS-STUTTGART

The Diarylprolinol Silyl Ether System: A General Organocatalyst

(2011) Kim L. Jensen et al.   ACCOUNTS OF CHEMICAL RESEARCH

One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether

(2011) Hayato Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple Recipe for Sophisticated Cocktails: Organocatalytic One-Pot Reactions-Concept, Nomenclature, and Future Perspectives

(2011) Łukasz Albrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of (-)-Oseltamivir by Using a Microreactor in the Curtius Rearrangement

(2011) Hayato Ishikawa et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Transition-Metal-Mediated or -Catalyzed Syntheses of Steroids and Steroid-Like Compounds

(2011) Martin Kotora et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalyzed Michael Addition of Aldehydes to Nitro Alkenes - Generally Accepted Mechanism Revisited and Revised

(2011) Krystyna Patora-Komisarska et al.   HELVETICA CHIMICA ACTA

Recent Development in Synthetic Strategies for Oseltamivir Phosphate

(2011) Masakatsu Shibasaki et al.   ISRAEL JOURNAL OF CHEMISTRY

Recent synthetic approaches to oseltamivir phosphate (Tamiflu™) for the treatment of influenza

(2011) Javier Magano   TETRAHEDRON

Organocatalytic Michael Addition of Aldehydes to Protected 2-Amino-1-Nitroethenes: The Practical Syntheses of Oseltamivir (Tamiflu) and Substituted 3-Aminopyrrolidines

(2010) Shaolin Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Yielding Synthesis of the Anti-Influenza Neuraminidase Inhibitor (−)-Oseltamivir by Two “One-Pot” Sequences

(2010) Hayato Ishikawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three “One-Pot” Operations

(2009) Hayato Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Economy in Organic Synthesis

(2009) Noah Z. Burns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza

(2009) Javier Magano   CHEMICAL REVIEWS

Asymmetric Aldol Reaction of Acetaldehyde and Isatin Derivatives for the Total Syntheses ofent-Convolutamydine E and CPC-1 and a Half Fragment of Madindoline A and B

(2009) Takahiko Itoh et al.   ORGANIC LETTERS

Asymmetric Michael Reaction of Acetaldehyde Catalyzed by Diphenylprolinol Silyl Ether

(2008) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Diarylprolinol in an Asymmetric, Catalytic, and Direct Crossed-Aldol Reaction of Acetaldehyde

(2008) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Strategies for Oseltamivir Phosphate

(2008) Masakatsu Shibasaki et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric, Catalytic, and Direct Self-Aldol Reaction of Acetaldehyde Catalyzed by Diarylprolinol

(2008) Yujiro Hayashi et al.   ORGANIC LETTERS

Global Green Chemistry Metrics Analysis Algorithm and Spreadsheets: Evaluation of the Material Efficiency Performances of Synthesis Plans for Oseltamivir Phosphate (Tamiflu) as a Test Case

(2008) John Andraos   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH