Review
Chemistry, Multidisciplinary
Yujiro Hayashi
Summary: Chemists aim to synthesize organic molecules rapidly to study their physical or biological properties, with concepts like time economy, step economy, and redox economy being crucial. One-pot reactions are useful in shortening synthesis time, increasing yield, and reducing chemical waste. The successful synthesis of natural products and medicines highlights the importance of pot and time economy, with efficient strategies such as using organocatalysts in one-pot reactions.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Hai-Hua Lu, Kang-Ji Gan, Fu-Qiang Ni, Zhihan Zhang, Yao Zhu
Summary: The concise total synthesis of salimabromide was achieved using a series of novel reactions, which allowed for the construction of its unique carbon skeleton and stereocenters.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Yan-Cheng Hu, Ying Li, Ding-Wei Ji, Heng Liu, Hao Zheng, Gong Zhang, Qing-An Chen
Summary: The study presents a straightforward method for C2 prenylation of NH indoles with good regioselectivity and broad substrate scope. The one-step process, catalyzed by acid, is efficient and atom-economical, suitable for late-stage diversification of tryptophan-based peptides and concise synthesis of tryprostatin B.
CHINESE JOURNAL OF CATALYSIS
(2021)
Article
Environmental Sciences
Ki-Hoon Lee, Junsung Noh, Jongmin Lee, Jong Seong Khim
Summary: The term 'Blue Economy (BE)' is gaining popularity in environmental research, aiming to explore ocean-based development opportunities with environmental stewardship. However, different scholars and actors often adopt this term in conflicting ways. To resolve this, a better understanding of the impact of the BE on the total environment is needed.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Chemistry, Organic
Takahiro Terunuma, Genki Kawauchi, Yujiro Hayashi
Summary: (-)-Quinine was synthesized in high enantio- and diastereoselectivity using an organocatalytic reaction as a key step. The reactions were optimized for pot economy and (-)-quinine was synthesized in 14 % yield only in 5 pots. This synthesis is efficient, environmentally benign, and important for the preparation of quinine derivatives.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Kyan A. D'Angelo, Carly K. Schissel, Bradley L. Pentelute, Mohammad Movassaghi
Summary: The study presents a concise total synthesis method for himastatin, a natural product with an unusual homodimeric structure. The final-stage dimerization strategy used in the synthesis was inspired by a detailed understanding of the compound's biogenesis. By combining this approach with a modular synthesis, a series of designed derivatives of himastatin, including synthetic probes to investigate its antibiotic activity, were efficiently accessed.
Article
Green & Sustainable Science & Technology
Edvaldo Pereira Santos Junior, Magno Vamberto Batista da Silva, Flavio Jose Simioni, Paulo Rotella Junior, Romulo Simoes Cezar Menezes, Luiz Moreira Coelho Junior
Summary: This article analyzed the location and concentration of forest bioelectricity in Brazil using various indicators. The results showed a significant growth in the scale and number of forest biomass power supply in Brazil, with a concentration in specific states and industrial pulp and paper complexes.
Article
Chemistry, Organic
Shigenobu Umemiya, Naoya Shinagawa, Masahiro Terada
Summary: A scalable total synthesis of leucascandrolide A macrolactone has been achieved in 17 steps with a longest linear sequence and a yield of 31.2% from readily available feedstocks. The key steps in this synthesis include enantioselective allylation reaction using chiral phosphoric acid (CPA)/CuBr cooperative catalysis and diastereoselective catalytic crotylation in the presence of CPA with CuCl. These catalytic reactions can be performed on a gram scale and result in excellent stereoselectivities.
Book Review
Chemistry, Multidisciplinary
Alexandros L. Zografos
Summary: Published by Wiley in 2018, this hardcover book has 512 pages and is priced at 195 euros. The ISBN is 978-1-118-60540-0.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Lauren G. O'Neil, John F. Bower
Summary: Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and these underpin a range of powerful C-N bond-forming processes. In this Review, we highlight the strategic use of electrophilic aminating agents in total synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chi He, Yu Wang, Cheng Bi, David S. Peters, Timothy J. Gallagher, Johannes Teske, Jason S. Chen, Rachel Corsetti, Anthony D'Onofrio, Kim Lewis, Phil S. Baran
Summary: A modular total synthesis method for kibdelomycin has been disclosed, which allows for structure-activity relationship studies. This method uses simple building blocks and addresses lingering questions regarding its structural assignment and its relationship to amycolamicin. Initial antibacterial assays indicate that both C-22 epimers of the natural product exhibit similar activity, while structurally truncated analogs lose activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Feng-Yuan Wang, Lei Jiao
Summary: An asymmetric total synthesis of cage-like indole alkaloid arborisidine is achieved using a new synthetic strategy that involves a catalytic parallel kinetic resolution based on ambident nucleophilicity of indole and a 5-exo-trig radical cyclization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hao Yu, Zachary P. Sercel, Samir P. Rezgui, Jonathan Farhi, Scott C. Virgil, Brian M. Stoltz
Summary: This study describes a synthetic approach to aleutianamine and highlights its potent biological activity against human pancreatic cancer cells, making it a potential candidate for therapeutic development.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Vasil H. Vasilev, Lukas Spessert, Kuan Yu, Thomas J. Maimone
Summary: The large family of daphnane diterpene orthoesters (DDOs) represents a remarkable class of natural products both in terms of structure and function. They are potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer. However, the synthesis of DDO natural products remains rare.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Yang Wang, Yongjian Su, Yanxing Jia
Summary: In this research, the structurally intriguing diterpene (+)-aberrarone was synthesized in only 12 steps from commercially available (S,S)-carveol without protecting group manipulations. This concise synthesis includes a Cu-catalyzed asymmetric hydroboration to generate the chiral methyl group, a Ni-catalyzed reductive coupling to link two fragments, and a Mn-mediated radical cascade cyclization to construct the triquinane system.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)