Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters

Epigenomic Assessment of Cardiovascular Disease Risk and Interactions With Traditional Risk Metrics

(2020) Kenneth Westerman et al.   Journal of the American Heart Association

Cardiac ketone body metabolism

(2020) Azrul Abdul Kadir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

(2019) Sabrina Chriett et al.   Scientific Reports

p53 β-hydroxybutyrylation attenuates p53 activity

(2019) Kun Liu et al.   Cell Death & Disease

Cardiovascular Effects of Treatment with the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

(2019) Roni Nielsen et al.   CIRCULATION

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

(2019) Xingrun Zhang et al.   Cell Discovery

Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: A scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force

(2019) C.F. Kirkpatrick et al.   Journal of Clinical Lipidology

Ketone body metabolism in diabetic and non-diabetic heart failure

(2019) Ningjing Qian et al.   HEART FAILURE REVIEWS

Metabolomic and microarray analyses of adipose tissue of dapagliflozin-treated mice, and effects of 3-hydroxybutyrate on induction of adiponectin in adipocytes

(2018) Shigeki Nishitani et al.   Scientific Reports

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

Metabolic gene expression and epigenetic effects of the ketone body β-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos

(2018) Juliano Rodrigues Sangalli et al.   Scientific Reports

Associations of Weight Gain From Early to Middle Adulthood With Major Health Outcomes Later in Life

(2017) Yan Zheng et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The diabetic heart utilizes ketone bodies as an energy source

(2017) Yuji Mizuno et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obesity and hypertension

(2017) Gino Seravalle et al.   PHARMACOLOGICAL RESEARCH

MicroRNA in cardiovascular biology and disease

(2017) Anna Wojciechowska et al.   Advances in Clinical and Experimental Medicine

Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics

(2016) Martyna Wojtala et al.   BIOFACTORS

Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury

(2016) Nurcan Orhan et al.   BRAIN RESEARCH

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Role of DNA methylation in cardiovascular diseases

(2016) Ye Zhang et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Hyperketonemia (Acetoacetate) Upregulates NADPH Oxidase 4 and Elevates Oxidative Stress, ICAM-1, and Monocyte Adhesivity in Endothelial Cells

(2015) Preeti Kanikarla-Marie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Concomitant Diabetes Mellitus and Heart Failure

(2015) Alessandra Dei Cas et al.   CURRENT PROBLEMS IN CARDIOLOGY

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

(2015) Tomohiro Matsuhashi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ageing induced vascular smooth muscle cell senescence in atherosclerosis

(2015) Anna K. Uryga et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of n-3 Polyunsaturated Fatty Acids (ω-3) Supplementation on Some Cardiovascular Risk Factors with a Ketogenic Mediterranean Diet

(2015) Antonio Paoli et al.   Marine Drugs

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

(2015) Theresa A. Lusardi et al.   NEUROPHARMACOLOGY

Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base

(2015) Richard D. Feinman et al.   NUTRITION

Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes

(2014) Feng Miao et al.   DIABETES

Vascular histone deacetylation by pharmacological HDAC inhibition

(2014) Haloom Rafehi et al.   GENOME RESEARCH

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

(2014) Rebecca C. Schugar et al.   Molecular Metabolism

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

(2013) Katja Kobow et al.   ACTA NEUROPATHOLOGICA

Two diets with different haemoglobin A1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes

(2013) S. B. Mayer et al.   DIABETES OBESITY & METABOLISM

Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

(2013) A Paoli et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

(2012) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Hyperketonemia increases monocyte adhesion to endothelial cells and is mediated by LFA-1 expression in monocytes and ICAM-1 expression in endothelial cells

(2011) Justin L. Rains et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cardiac anaplerosis in health and disease: food for thought

(2011) C. Des Rosiers et al.   CARDIOVASCULAR RESEARCH

Cellular Senescence, Vascular Disease, and Aging

(2011) Jason C. Kovacic et al.   CIRCULATION

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

(2011) L. Pirola et al.   GENOME RESEARCH

Cardiovascular Epigenetics

(2010) Andrea Baccarelli et al.   Circulation-Cardiovascular Genetics

Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

(2008) Jeff S. Volek et al.   LIPIDS