Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer

Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways

(2018) Hui Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Novel application of metformin combined with targeted drugs on anticancer treatment

(2018) Jun Deng et al.   CANCER SCIENCE

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer

(2017) Hui Yang et al.   Scientific Reports

Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production

(2017) Angela Mogavero et al.   Scientific Reports

Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model

(2016) Xilong Wu et al.   BIOMATERIALS

Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma

(2016) KOJI HARADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ZNF32 contributes to the induction of multidrug resistance by regulating TGF-β receptor 2 signaling in lung adenocarcinoma

(2016) Jun Li et al.   Cell Death & Disease

Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer

(2016) Ali Flores-Pérez et al.   Scientific Reports

Metformin induces degradation of mTOR protein in breast cancer cells

(2016) Mohamed Alalem et al.   Cancer Medicine

Metformin is a novel suppressor for transforming growth factor (TGF)-β1

(2016) Han Xiao et al.   Scientific Reports

Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk

(2016) Mei Peng et al.   Scientific Reports

Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach

(2015) Moisés Blanco-Calvo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis

(2015) X Meng et al.   ONCOGENE

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

(2014) L. Li et al.   CLINICAL CANCER RESEARCH

Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer

(2014) SOICHIRO HONJO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer

(2014) Wenpeng Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Repurposing To Fight Cancer: The Metformin-Prostate Cancer Connection

(2014) A. Azvolinsky   JNCI-Journal of the National Cancer Institute

Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

(2014) Eveline A. I. F. Queiroz et al.   PLoS One

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth inhibition of colon cancer cells by compounds affecting AMPK activity

(2014) Michael A Lea   World Journal of Gastrointestinal Oncology

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Association of metformin use with cancer incidence and mortality: A meta-analysis

(2013) Pengpeng Zhang et al.   Cancer Epidemiology

Metformin targets c-MYC oncogene to prevent prostate cancer

(2013) Tunde Akinyeke et al.   CARCINOGENESIS

Improving outcomes in colorectal cancer: Where do we go from here?

(2013) Eric Van Cutsem et al.   EUROPEAN JOURNAL OF CANCER

Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells

(2013) Chen Qu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer

(2013) S Busch et al.   ONCOGENE

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

TGF-beta signalling in colon carcinogenesis

(2011) Pavlos Lampropoulos et al.   CANCER LETTERS

STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells

(2011) L. Lin et al.   CANCER RESEARCH

Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins

(2011) Amber Yasmeen et al.   GYNECOLOGIC ONCOLOGY

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase

(2008) M. Zakikhani et al.   Cancer Prevention Research

Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis

(2008) X Li et al.   ONCOGENE