Application of CAR-T Cell Therapy beyond Oncology: Autoimmune Diseases and Viral Infections

Virus-specific T-cell therapies for patients with primary immune deficiency

(2020) Michael D. Keller et al.   BLOOD

Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment

(2020) Aleksei Titov et al.   Cancers

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

(2020) James T. England et al.   BLOOD REVIEWS

Amelioration of COVID‐19‐related cytokine storm syndrome: parallels to chimeric antigen receptor‐T cell cytokine release syndrome

(2020) Ryan L. Hoiland et al.   BRITISH JOURNAL OF HAEMATOLOGY

Evaluation of a Fully Human, Hepatitis B Virus-Specific Chimeric Antigen Receptor in an Immunocompetent Mouse Model

(2019) Marvin M. Festag et al.   MOLECULAR THERAPY

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology

(2019) Geetha Mylvaganam et al.   Frontiers in Immunology

CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart

(2019) Ronald J. Vagnozzi et al.   MOLECULAR THERAPY

Development of CAR-T cells for long-term eradication and surveillance of HIV-1 reservoir

(2019) Bingfeng Liu et al.   Current Opinion in Virology

CAR T Cells Beyond Cancer: Hope for Immunomodulatory Therapy of Infectious Diseases

(2019) Michelle Seif et al.   Frontiers in Immunology

Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma

(2019) Abdolreza Esmaeilzadeh et al.   BIOMEDICINE & PHARMACOTHERAPY

Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti–human immunodeficiency virus potency and breadth with minimal immunogenicity

(2018) Mustafa H. Ghanem et al.   CYTOTHERAPY

HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice

(2018) Robert L. Kruse et al.   CYTOTHERAPY

Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

(2018) Julia Proff et al.   Journal of Translational Medicine

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes

(2018) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

The biological basis and clinical symptoms of CAR-T therapy-associated toxicites

(2018) Aleksei Titov et al.   Cell Death & Disease

Chimeric Antigen Receptors Based on Low Affinity Mutants of FcεRI Re-direct T Cell Specificity to Cells Expressing Membrane IgE

(2018) Dana E. Ward et al.   Frontiers in Immunology

Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes

(2017) Sigal Fishman et al.   MOLECULAR THERAPY

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

(2017) Rachel S. Leibman et al.   PLoS Pathogens

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma

(2017) Jelena Skuljec et al.   Frontiers in Immunology

HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies

(2016) Ayub Ali et al.   JOURNAL OF VIROLOGY

Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4 + T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

(2016) Bingfeng Liu et al.   JOURNAL OF VIROLOGY

Prospects for gene-engineered T cell immunotherapy for solid cancers

(2016) Christopher A Klebanoff et al.   NATURE MEDICINE

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein

(2015) Giuseppe A Sautto et al.   GUT

Human autoimmune diseases: a comprehensive update

(2015) Lifeng Wang et al.   JOURNAL OF INTERNAL MEDICINE

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

(2015) Li Liu et al.   JOURNAL OF VIROLOGY

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

(2013) Karin Krebs et al.   GASTROENTEROLOGY

Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells

(2013) Gautam K. Sahu et al.   VIROLOGY

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation