MiRNA‐516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis

Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy

(2020) Honglei Jin et al.   Autophagy

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Autophagy-mediated Mir6981 degradation exhibits CDKN1B promotion of PHLPP1 protein translation

(2019) Minggang Peng et al.   Autophagy

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Krüppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion

(2018) Xiao-Yan Bai et al.   CANCER LETTERS

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

(2018) Minggang Peng et al.   ONCOGENE

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

(2017) Chao Huang et al.   Journal of Hematology & Oncology

Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway

(2017) Ming Bai et al.   ONCOLOGY REPORTS

Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication

(2017) Mingjing He et al.   PHARMACOLOGY & THERAPEUTICS

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

(2017) Yang Li et al.   Nature Communications

PHLPPing through history: a decade in the life of PHLPP phosphatases

(2016) A. T. Grzechnik et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

(2016) Agata Jabłońska-Trypuć et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression

(2016) J Gao et al.   Cell Death & Disease

PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure

(2015) H. Huang et al.   CLINICAL CANCER RESEARCH

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Moving targets: Emerging roles for MMPs in cancer progression and metastasis

(2015) Gemma Shay et al.   MATRIX BIOLOGY

Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines

(2015) Honglei Jin et al.   Oncotarget

miR-138 inhibits proliferation by targeting 3-phosphoinositide-dependent protein kinase-1 in non-small cell lung cancer cells

(2014) Xian-wei Ye et al.   Clinical Respiratory Journal

MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2

(2014) Zhoufang Mei et al.   FEBS LETTERS

ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance

(2014) Meilin Wang et al.   Nature Communications

Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients

(2014) Charles-Henry Gattolliat et al.   Cancer Medicine

Recurrence of high-risk bladder cancer: A population-based analysis

(2013) Karim Chamie et al.   CANCER

miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non-Small Cell Lung Cancer

(2013) J. Cai et al.   CANCER RESEARCH

microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

(2013) W.-T. Liao et al.   CLINICAL CANCER RESEARCH

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

(2013) Jennifer Vandooren et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Smurf E3 ubiquitin ligases at the cross roads of oncogenesis and tumor suppression

(2012) Diana David et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The dark side of a success story: microRNAs of the C19MC cluster in human tumours

(2012) Inga Flor et al.   JOURNAL OF PATHOLOGY

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

(2012) Francesca Fornari et al.   JOURNAL OF PATHOLOGY

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

(2011) J R Molina et al.   ONCOGENE

The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta

(2010) M. Noguer-Dance et al.   HUMAN MOLECULAR GENETICS

Protein Phosphatase 2A Reactivates FOXO3a through a Dynamic Interplay with 14-3-3 and AKT

(2010) Amrik Singh et al.   MOLECULAR BIOLOGY OF THE CELL

Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells

(2009) Lisa E. S. Crose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases

(2009) P. Storz et al.   MOLECULAR AND CELLULAR BIOLOGY

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration

(2009) Cai Huang et al.   NATURE CELL BIOLOGY

C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts

(2009) M.-L. Bortolin-Cavaille et al.   NUCLEIC ACIDS RESEARCH

Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway

(2008) Kei Yamaguchi et al.   BIOLOGICAL CHEMISTRY

Targeted Therapies in Non–Small-Cell Lung Cancer: A Paradigm in Evolution

(2008) Randeep Sangha et al.   Clinical Lung Cancer

MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors

(2008) Fernando Colbari Amaral et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transcriptional Activation of Human Matrix Metalloproteinase-9 Gene Expression by Multiple Co-activators

(2008) Xueyan Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

(2008) J Liu et al.   ONCOGENE