Poxviral Strategies to Overcome Host Cell Apoptosis

Novel insights in the role of Bcl-2 homolog Nr-13 (vNr-13) encoded by herpesvirus of turkeys in the virus replication cycle, mitochondrial networks and apoptosis inhibition

(2020) Vishwanatha R. A. P. Reddy et al.   JOURNAL OF VIROLOGY

The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms

(2020) Suresh Banjara et al.   Biomolecules

Structural insight into tanapoxvirus‐mediated inhibition of apoptosis

(2020) Chathura D. Suraweera et al.   FEBS Journal

Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax

(2020) Chathura D. Suraweera et al.   FEBS LETTERS

Controlling Cell Death through Post-translational Modifications of DED Proteins

(2020) Kamil Seyrek et al.   TRENDS IN CELL BIOLOGY

The structural basis of Bcl-2 mediated cell death regulation in Hydra

(2020) Suresh Banjara et al.   BIOCHEMICAL JOURNAL

Vaccinia Virus Immunomodulator A46: Destructive Interactions with MAL and MyD88 Shown by Negative-Stain Electron Microscopy

(2020) Daniel F. Azar et al.   STRUCTURE

Poxviral Targeting of Interferon Regulatory Factor Activation

(2020) Clara Lawler et al.   Viruses-Basel

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

(2020) Nikolay Popgeorgiev et al.   Science Advances

Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis

(2020) Chathura D. Suraweera et al.   BIOCHEMICAL JOURNAL

PKR: A Kinase to Remember

(2019) Shunit Gal-Ben-Ari et al.   Frontiers in Molecular Neuroscience

NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation

(2019) Sarah Neidel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants

(2019) David T. Bloomer et al.   BIOCHEMICAL JOURNAL

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim

(2018) Suresh Banjara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of vaccinia viral protein B14–mediated inhibition of IκB kinase β activation

(2018) Qingyu Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes

(2018) Sunetra Biswas et al.   JOURNAL OF GENERAL VIROLOGY

Understanding orthopoxvirus host range and evolution: from the enigmatic to the usual suspects

(2018) Mary G Reynolds et al.   Current Opinion in Virology

A structural investigation of NRZ mediated apoptosis regulation in zebrafish

(2018) Chathura D. Suraweera et al.   Cell Death & Disease

Vaccinia virus evasion of regulated cell death

(2017) David L. Veyer et al.   IMMUNOLOGY LETTERS

Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039

(2017) Mohd Ishtiaq Anasir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome

(2017) Melissa R. Ryerson et al.   JOURNAL OF VIROLOGY

Distinct Roles of Vaccinia Virus NF-κB Inhibitor Proteins A52, B15, and K7 in the Immune Response

(2017) Mauro Di Pilato et al.   JOURNAL OF VIROLOGY

Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis

(2017) Suresh Banjara et al.   JOURNAL OF VIROLOGY

The Molluscum Contagiosum Virus protein MC163 localizes to the mitochondria and dampens mitochondrial mediated apoptotic responses

(2017) Jesse Coutu et al.   VIROLOGY

The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions

(2017) Michael Beaury et al.   VIRUS GENES

Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis

(2017) et al.   Viruses-Basel

Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis

(2017) Mohd Anasir et al.   Viruses-Basel

The Bcl-2 Family in Host-Virus Interactions

(2017) Marc Kvansakul et al.   Viruses-Basel

Structural insight into an evolutionarily ancient programmed cell death regulator – the crystal structure of marine sponge BHP2 bound to LB-Bak-2

(2017) Sofia Caria et al.   Cell Death & Disease

Distinct roles of TNF-related apoptosis-inducing ligand (TRAIL) in viral and bacterial infections: from pathogenesis to pathogen clearance

(2016) Valeriya Gyurkovska et al.   INFLAMMATION RESEARCH

The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation

(2016) Sofia Caria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molluscum Contagiosum Virus Transcriptome in Abortively Infected Cultured Cells and a Human Skin Lesion

(2016) Jorge D. Mendez-Rios et al.   JOURNAL OF VIROLOGY

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

(2016) Tian-Min Fu et al.   MOLECULAR CELL

Bcl-2 proteins and calcium signaling: complexity beneath the surface

(2016) T Vervliet et al.   ONCOGENE

Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins

(2016) Sofiya Fedosyuk et al.   PLoS Pathogens

Poxvirus Decapping Enzymes Enhance Virulence by Preventing the Accumulation of dsRNA and the Induction of Innate Antiviral Responses

(2015) Shin-Wu Liu et al.   Cell Host & Microbe

Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors

(2015) Sergio M. Pontejo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia Virus Protein A49 Is an Unexpected Member of the B-cell Lymphoma (Bcl)-2 Protein Family

(2015) Sarah Neidel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration

(2015) Guia Carrara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions

(2015) Avi Ashkenazi   JOURNAL OF CLINICAL INVESTIGATION

Functional Comparison of Molluscum Contagiosum Virus vFLIP MC159 with Murine Cytomegalovirus M36/vICA and M45/vIRA Proteins

(2015) Julia Hüttmann et al.   JOURNAL OF VIROLOGY

Review: Capripoxvirus Diseases: Current Status and Opportunities for Control

(2015) E. S. M. Tuppurainen et al.   Transboundary and Emerging Diseases

Ectromelia virus encodes an anti-apoptotic protein that regulates cell death

(2015) Ninad Mehta et al.   VIROLOGY

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim

(2015) B Marshall et al.   Cell Death & Disease

Structural basis ofDeerpox virus-mediated inhibition of apoptosis

(2015) Denis R. Burton et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Bcl-2 family: structures, interactions and targets for drug discovery

(2014) Marc Kvansakul et al.   APOPTOSIS

Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection

(2014) D. L. Veyer et al.   JOURNAL OF GENERAL VIROLOGY

Recombinant Modified Vaccinia Virus Ankara Generating Excess Early Double-Stranded RNA Transiently Activates Protein Kinase R and Triggers Enhanced Innate Immune Responses

(2014) M. Wolferstatter et al.   JOURNAL OF VIROLOGY

Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L

(2014) S. Campbell et al.   JOURNAL OF VIROLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif

(2014) Yongwoon Kim et al.   PROTEIN SCIENCE

Human Monkeypox

(2013) A. M. McCollum et al.   CLINICAL INFECTIOUS DISEASES

Poxviruses and the evolution of host range and virulence

(2013) Sherry L. Haller et al.   INFECTION GENETICS AND EVOLUTION

Characterization and Structure of the Vaccinia Virus NF-κB Antagonist A46

(2013) Sofiya Fedosyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human and Viral Golgi Anti-apoptotic Proteins (GAAPs) Oligomerize via Different Mechanisms and Monomeric GAAP Inhibits Apoptosis and Modulates Calcium

(2013) Nuno Saraiva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

(2013) G. L. Smith et al.   JOURNAL OF GENERAL VIROLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

(2013) M. Gerlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poxvirus DNA Replication

(2013) B. Moss   Cold Spring Harbor Perspectives in Biology

Structural biology of the Bcl-2 family and its mimicry by viral proteins

(2013) M Kvansakul et al.   Cell Death & Disease

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

(2013) Masmudur M. Rahman et al.   PLoS Pathogens

Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

(2013) Daniel S. Mansur et al.   PLoS Pathogens

Six-transmembrane Topology for Golgi Anti-apoptotic Protein (GAAP) and Bax Inhibitor 1 (BI-1) Provides Model for the Transmembrane Bax Inhibitor-containing Motif (TMBIM) Family

(2012) Guia Carrara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

(2012) T. Okamoto et al.   JOURNAL OF VIROLOGY

PKR-Dependent Inflammatory Signals

(2012) R. Kang et al.   Science Signaling

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis

(2011) Peter E. Czabotar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of Caspase-9 Inhibition by the Vaccinia Virus Protein, F1L

(2011) Eric Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Vaccinia Virus E3 Protein by Small Ubiquitin-Like Modifier Proteins

(2011) J. Gonzalez-Santamaria et al.   JOURNAL OF VIROLOGY

Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus Pathogenicity

(2011) C. Myskiw et al.   JOURNAL OF VIROLOGY

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

(2011) Carlos Maluquer de Motes et al.   PLoS Pathogens

BH3-only proteins: Orchestrators of apoptosis

(2010) Aisha Shamas-Din et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane

(2010) Z T Schug et al.   CELL DEATH AND DIFFERENTIATION

Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax

(2010) L. Banadyga et al.   JOURNAL OF VIROLOGY

A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history

(2010) José M González et al.   Virology Journal

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax

(2009) Dana Westphal et al.   APOPTOSIS

Vaccinia Virus F1L Interacts with Bak Using Highly Divergent Bcl-2 Homology Domains and Replaces the Function of Mcl-1

(2009) Stephanie Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor

(2009) Dayong Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poxvirus MC160 Protein Utilizes Multiple Mechanisms To Inhibit NF- B Activation Mediated via Components of the Tumor Necrosis Factor Receptor 1 Signal Transduction Pathway

(2009) D. B. Nichols et al.   JOURNAL OF VIROLOGY

The Fowlpox Virus BCL-2 Homologue, FPV039, Interacts with Activated Bax and a Discrete Subset of BH3-Only Proteins To Inhibit Apoptosis

(2009) L. Banadyga et al.   JOURNAL OF VIROLOGY

Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein

(2009) Zhiru Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

(2009) A. L. Desbien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Targeting of Human RNA Helicase DDX3 by Poxvirus Protein K7

(2009) Shun-ichiro Oda et al.   STRUCTURE

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

(2008) M Kvansakul et al.   CELL DEATH AND DIFFERENTIATION

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Monkeypox virus and insights into its immunomodulatory proteins

(2008) Jessica R. Weaver et al.   IMMUNOLOGICAL REVIEWS

Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3

(2008) Arnout P. Kalverda et al.   JOURNAL OF MOLECULAR BIOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Expansion and evolution of cell death programmes

(2008) Alexei Degterev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

(2008) Stefan Schütze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

(2008) Bonsu Ku et al.   PLoS Pathogens

A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa

(2008) Inmaculada Galindo et al.   VIROLOGY

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

(2008) Stephen C. Graham et al.   PLoS Pathogens

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY