Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson’s Disease

Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling

(2020) Matthew A. Held et al.   CELLULAR SIGNALLING

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

(2020) Matteo Bordoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Does recombinant human erythropoietin administration in critically ill COVID‐19 patients have miraculous therapeutic effects?

(2020) Azar Hadadi et al.   JOURNAL OF MEDICAL VIROLOGY

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

(2020) Debia Wakhloo et al.   Nature Communications

Erythropoietin as candidate for supportive treatment of severe COVID-19

(2020) Hannelore Ehrenreich et al.   MOLECULAR MEDICINE

Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?

(2020) Jorge Soliz et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease

(2020) A.M. Thompson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aβ peptide

(2019) C. Castillo et al.   Redox Biology

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

(2019) Rong Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Erythropoietin induces synaptogenesis and neurite repair after hypoxia ischemia-mediated brain injury in neonatal rats

(2019) Tao Xiong et al.   NEUROREPORT

Glycolysis as a therapeutic target for Parkinson's disease

(2019) Thomas Foltynie   LANCET NEUROLOGY

Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress

(2018) C. Castillo et al.   Redox Biology

Counteracting neuroinflammation in experimental Parkinson’s disease favors recovery of function: effects of Er-NPCs administration

(2018) Stephana Carelli et al.   Journal of Neuroinflammation

Targeting urate to reduce oxidative stress in Parkinson disease

(2017) Grace F. Crotty et al.   EXPERIMENTAL NEUROLOGY

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

(2017) Jayne Louise Wilson et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimer’s disease, Parkinson’s disease, and diabetes

(2017) Aya Umeno et al.   FREE RADICAL RESEARCH

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes

(2017) Vincent R. Parillaud et al.   Journal of Neuroinflammation

Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats

(2017) Nadia Aalling et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Recovery from experimental parkinsonism by intrastriatal application of erythropoietin or EPO-releasing neural precursors

(2017) Stephana Carelli et al.   NEUROPHARMACOLOGY

Brain adaptation to hypoxia and hyperoxia in mice

(2017) Laura Terraneo et al.   Redox Biology

Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice

(2016) Stephana Carelli et al.   ASN Neuro

Isoforms of the Erythropoietin receptor in dopaminergic neurons of theSubstantia Nigra

(2016) Federica Marcuzzi et al.   JOURNAL OF NEUROCHEMISTRY

PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease

(2016) Giuseppe Arena et al.   JOURNAL OF PATHOLOGY

Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models

(2016) Chien Tai Hong et al.   Scientific Reports

Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson’s disease dementia

(2015) Chiu-Ku Huang et al.   BEHAVIOURAL BRAIN RESEARCH

DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulatingpink1

(2015) Raquel Requejo-Aguilar et al.   BIOCHEMICAL JOURNAL

The Neuroprotective Effect of Erythropoietin on Rotenone-Induced Neurotoxicity in SH-SY5Y Cells Through the Induction of Autophagy

(2015) Wooyoung Jang et al.   MOLECULAR NEUROBIOLOGY

Enhanced brain release of erythropoietin, cytokines and NO during carotid clamping

(2015) Stephana Carelli et al.   NEUROLOGICAL SCIENCES

The neuroprotective effect of erythropoietin on experimental Parkinson model in rats

(2015) Oytun Erbaş et al.   NEUROPEPTIDES

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

Quantitative Analysis of Histological Staining and Fluorescence Using ImageJ

(2014) Ellen C. Jensen   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300

(2014) Miyeon Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Bioenergetic Health Index: a new concept in mitochondrial translational research

(2014) Balu K. Chacko et al.   CLINICAL SCIENCE

Erythropoietin improves neurobehavior by reducing dopaminergic neuron loss in a 6-hydroxydopamine-induced rat model

(2014) CHEN QI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

EPO-Dependent Activation of PI3K/Akt/FoxO3a Signalling Mediates Neuroprotection in In Vitro and In Vivo Models of Parkinson’s Disease

(2014) Yu Jia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia

(2014) Wesley S. Bond et al.   Frontiers in Immunology

Activation of mitochondrial function and Hb expression in non-haematopoietic cells by an EPO inducer ameliorates ischaemic diseases in mice

(2013) Pei-Lun Hsu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson's disease

(2013) Wooyoung Jang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Erythropoietin Increases Neurogenesis and Oligodendrogliosis of Subventricular Zone Precursor Cells After Neonatal Stroke

(2013) Fernando F. Gonzalez et al.   STROKE

Erythropoietin

(2013) H. F. Bunn   Cold Spring Harbor Perspectives in Medicine

Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study

(2012) Laurence Mille-Hamard et al.   BMC Medical Genomics

Erythropoietin: New Directions for the Nervous System

(2012) Kenneth Maiese et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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(2012) Michael Brines et al.   MOLECULAR MEDICINE

Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell Death

(2012) Samantha Giordano et al.   PLoS One

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

(2012) J H Zhu et al.   Cell Death & Disease

Anti-Inflammatory Effect of Erythropoietin Therapy on Experimental Autoimmune Encephalomyelitis

(2011) Xiang Zhang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Adult neural precursors isolated from post mortem brain yield mostly neurons: An erythropoietin-dependent process

(2011) Giovanni Marfia et al.   NEUROBIOLOGY OF DISEASE

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Erythropoietin: A Hormone with Multiple Functions

(2011) Matilde Lombardero et al.   PATHOBIOLOGY

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies

(2010) Fernanda Martins Lopes et al.   BRAIN RESEARCH

Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice

(2009) Yi-Fang Cui et al.   BRAIN

Vertical grid test and modified horizontal grid test are sensitive methods for evaluating motor dysfunctions in the MPTP mouse model of Parkinson's disease

(2009) Sung Tae Kim et al.   BRAIN RESEARCH

Erythropoietin protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway

(2009) Rong Ma et al.   NEUROPHARMACOLOGY

Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection

(2009) E. Gunnarson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY