Article
Ecology
Pedro Duque, Cristina P. Vieira, Barbara Bastos, Jorge Vieira
Summary: Vitamin C is essential for the optimal function and development of cells. Animals can synthesize or acquire vitamin C through diet. The genes GULO and Regucalcin are involved in vitamin C synthesis, with Regucalcin having multiple functions in mammals. Different animal taxonomic groups have experienced different selective pressures.
BMC ECOLOGY AND EVOLUTION
(2022)
Review
Medicine, General & Internal
Mariano Andres, Francisca Sivera, Rachelle Buchbinder, Jordi Pardo Pardo, Loreto Carmona
Summary: The efficacy and safety of dietary supplements for people with chronic gout are still controversial. Currently, the effects of using protein supplements or vitamin C for gout patients are not significant, which may not have a great clinical relevance.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Wenzhong Hu, Yun Xu
Summary: This study analyzed the relationship between COVID-19 and dietary supplements through bibliometric analysis. The research found that vitamin D is the mainstream dietary supplement for COVID-19, but there are still many controversial issues that require further discussion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Beguem Hatice Tuna, Murat Guerbuez, Halime Ugur, Jale catak, Mustafa Yaman
Summary: Knowing the bioaccessibility of vitamin C in commercial dietary supplements is important for determining daily intake. This study found that most supplements had a measured vitamin C amount close to or higher than the declared amount. The bioaccessibility of vitamin C was higher in mono-supplements compared to multi-supplements.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Malgorzata Starek, Pawel Gumulka, Monika Dabrowska
Summary: Nowadays, the quality of dietary supplements is of utmost importance due to reports of insufficient content or absence of ingredients. This study developed optimal conditions for analyzing the content of vitamins D-2, D-3, and K-2 in various dietary supplements. The results showed that the methodology developed was reliable and met analytical requirements. The amount of vitamin D-3 in the analyzed products matched the manufacturer's declaration, while the content of vitamin K-2 varied.
Review
Food Science & Technology
Evmorfia Pechlivanidou, Dimitrios Vlachakis, Konstantinos Tsarouhas, Dimitris Panidis, Christina Tsitsimpikou, Christina Darviri, Dimitrios Kouretas, Flora Bacopoulou
Summary: Micronutrients serve as an additional treatment for respiratory viral infections and may have a positive impact on the prognosis of COVID-19 patients. Vitamin D and calcium are the most studied micronutrients and have the potential to benefit patients.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Nutrition & Dietetics
Bhavdeep Singh, Eli Eshaghian, Judith Chuang, Mihai Covasa
Summary: This article discusses the potential roles of diet and supplementation in preventing and treating COVID-19. While the impact of nutrition on other respiratory illnesses has been studied, there is less research on the specific impact related to COVID-19. The evidence regarding the efficacy of diet supplementation on infection risk, disease severity, and recovery is inconsistent.
Review
Microbiology
Ronan Lordan, Halie M. Rando, Casey S. Greene
Summary: This review critically evaluates the evidence surrounding the potential prophylactic and therapeutic value of dietary supplements and nutraceuticals for COVID-19. While nutritional status plays a significant role in patient outcomes and certain products like vitamin D may hold promise, further research is necessary to formulate evidence-based recommendations. Sales of these products have surged during the pandemic, but more research is needed to determine their efficacy against SARS-CoV-2 and COVID-19.
Article
Food Science & Technology
Dagmara Wozniak, Juliusz Przyslawski, Michalina Banaszak, Slawomira Drzymala-Czyz
Summary: The research found that 79% of children received dietary supplements. The levels of vitamin D and omega-3 fatty acids were low, while the levels of vitamin C, vitamin B, vitamin A, and copper were high. Therefore, it is necessary to increase parents' knowledge in choosing and using dietary supplements tailored to individual needs.
Article
Nutrition & Dietetics
Xiaoqin Luo, Wanyu Zhang, Zhangya He, Hexiang Yang, Jiayi Gao, Pei Wu, Zheng Feei Ma
Summary: This study found that increasing dietary vitamin C intake can improve glucose metabolism and liver function, possibly by reducing iron accumulation indicated by ferritin.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Ishrat Jahan, Abul Bashar Mohammad Neshar Uddin, A. S. M. Ali Reza, Md Giash Uddin, Mohammad Shahadat Hossain, Mst Samima Nasrin, Talha Bin Emran, Md Atiar Rahman
Summary: The study investigates the tendencies and attitudes of Bangladeshi undergraduate female students towards dietary supplements (DS) in Chittagong. Results show a high prevalence of DS use among these students with most agreeing on the beneficial effects and recommending regular use. The study also indicates a higher prevalence of dietary supplements in students of private universities compared to public universities, and especially in the pharmacy department. Students in the study preferred brand products and had positive opinions and attitudes towards dietary supplements.
Review
Endocrinology & Metabolism
Vinesh Dahiya, Neeru Vasudeva, Sunil Sharma, Ashok Kumar
Summary: This article analyzed the benefits and risks of using dietary supplements for the prevention and treatment of various thyroid disorders. It emphasized the importance of nutrients for thyroid function and highlighted the potential risks associated with the use of dietary supplements.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Nutrition & Dietetics
Saumya Singh, Prithwish Kola, Dalveer Kaur, Gisha Singla, Vibhu Mishra, Parmjit S. Panesar, Kumar Mallikarjunan, Meena Krishania
Summary: Despite significant scientific advancements, viral diseases continue to be the leading cause of illness worldwide, with the potential for pandemics. Nutrition plays a crucial role in supporting the immune system and combating various viral infections. Studies suggest that bioactive compounds such as nutraceuticals, vitamins, and functional foods, along with milk proteins and peptides, can strengthen the immune system and aid in treating virus-induced infections.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Jadwiga Hamulka, Marta Jeruszka-Bielak, Magdalena Gornicka, Malgorzata E. Drywien, Monika A. Zielinska-Pukos
Summary: The use of dietary supplements (DSs) increased globally during the COVID-19 outbreak in 2020, mainly for enhancing immunity. Most respondents started supplementation during the first wave of the pandemic rather than the second. While there is evidence supporting the role of certain nutrients in patients with deficiencies, there is limited clear evidence for the role of DSs in preventing and treating COVID-19 in healthy individuals.
Review
Cardiac & Cardiovascular Systems
Marco Bruno Morelli, Chiara Bongiovanni, Silvia Da Pra, Carmen Miano, Francesca Sacchi, Mattia Lauriola, Gabriele D'Uva
Summary: Chemotherapy and targeted therapies can cause cardiotoxicity, leading to cardiac dysfunction and affecting survival and quality of life. Cardiotoxicity can be reversible or irreversible, and there is a need for cardioprotective therapies to reduce its occurrence and progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Pasquale Mone, Antonella Pansini, Fahimeh Varzideh, Antonio de Donato, Stanislovas S. Jankauskas, Gaetano Santulli
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Linda Sasset, Onorina Laura Manzo, Yi Zhang, Alice Marino, Luisa Rubinelli, Maria Antonietta Riemma, Madhavi Latha S. Chalasani, Dragos C. Dasoveanu, Fiorentina Roviezzo, Stanislovas S. Jankauskas, Gaetano Santulli, Maria Rosaria Bucci, Theresa T. Lu, Annarita Di Lorenzo
Summary: Nogo-A acts as a negative regulator of ceramide synthesis by inhibiting SPT activity, thereby limiting ceramide accumulation in cardiomyocytes and protecting against heart failure. Lack of Nogo-A leads to cardiac hypertrophy and dysfunction, ultimately resulting in the progression of heart failure.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Stanislovas S. Jankauskas, Pasquale Mone, Gaetano Santulli
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jessica Gambardella, Antonella Fiordelisi, Daniela Sorriento, Federica Cerasuolo, Antonietta Buonaiuto, Roberta Avvisato, Antonio Pisani, Fahimeh Varzideh, Eleonora Riccio, Gaetano Santulli, Guido Iaccarino
Summary: Fabry disease is a lysosomal storage disorder caused by mutations in the gene for alpha-galactosidase A, leading to the accumulation of globotriaosylceramide. The clinical manifestations of the disease cannot be fully explained by the accumulation of globotriaosylceramide, and other mechanisms are proposed, necessitating the identification of new biomarkers for monitoring Fabry disease patients.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Tullio Tesorio, Pasquale Mone, Antonio de Donato, Valentina Trimarco, Gaetano Santulli
Article
Pharmacology & Pharmacy
Valentina Trimarco, Raffaele Izzo, Pasquale Mone, Maria Lembo, Maria Virginia Manzi, Daniela Pacella, Angela Falco, Paola Gallo, Giovanni Esposito, Carmine Morisco, Gaetano Santulli, Bruno Trimarco
Summary: Therapeutic concordance significantly improves the outcome of antihypertensive treatment in patients with therapy-resistant hypertension.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Stanislovas S. Jankauskas, Urna Kansakar, Celestino Sardu, Fahimeh Varzideh, Roberta Avvisato, Xujun Wang, Alessandro Matarese, Raffaele Marfella, Marcello Ziosi, Jessica Gambardella, Gaetano Santulli
Summary: This study investigated the impact of COVID-19 on lipid peroxidation and ferroptosis in human endothelial cells. The serum from non-survivors of COVID-19 significantly increased lipid peroxidation and regulated the expression levels of markers of ferroptosis. These findings suggest a link between oxidative stress in endothelial cells induced by COVID-19 and the disease outcome.
Editorial Material
Cardiac & Cardiovascular Systems
Pasquale Mone, Tullio Tesorio, Antonio De Donato, Angelo Cioppa, Stanislovas S. Jankauskas, Luigi Salemme, Gaetano Santulli
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jessica Gambardella, Gaetano Santulli, Antonella Fiordelisi, Federica Andrea Cerasuolo, Xujun Wang, Nella Prevete, Eduardo Sommella, Roberta Avvisato, Antonietta Buonaiuto, Giovanna Giuseppina Altobelli, Laura Rinaldi, Francesco Chiuso, Antonio Feliciello, Fabrizio Dal Piaz, Pietro Campiglia, Michele Ciccarelli, Carmine Morisco, Junichi Sadoshima, Guido Iaccarino, Daniela Sorriento
Summary: The role of macrophages in cardiac damage elicited by Dox treatment was evaluated in this study. The results showed that macrophage infiltration preceded cardiac damage induced by Dox, and macrophage depletion prevented Dox-induced damage. In vitro experiments demonstrated that catecholamines released by Dox-activated macrophages induced mitochondrial apoptosis of cardiac cells through beta-AR stimulation. This indicates the importance of the crosstalk between macrophages and cardiac cells in Dox-induced cardiac damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Imma Forzano, Scott Wilson, Angela Lombardi, Stanislovas S. Jankauskas, Urna Kansakar, Pasquale Mone, Fahimeh Varzideh, Gaetano Santulli
Summary: This article summarizes the recent therapeutic progress in the cardiovascular field obtained with SGLT2 inhibitors, including the clinical study results on their effects on cardiovascular outcomes, and provides a brief overview of the main ongoing clinical trials designed to address the unanswered questions in the field.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Review
Peripheral Vascular Disease
Gaetano Santulli, Fahimeh Varzideh, Imma Forzano, Scott Wilson, Luigi Salemme, Antonio de Donato, Angela Lombardi, Antonio Rainone, Luigi Nunziata, Stanislovas S. Jankauskas, Tullio Tesorio, Germano Guerra, Urna Kansakar, Pasquale Mone
Summary: SGLT2 inhibitors have beneficial effects on kidney and heart function, and they can improve physical and cognitive impairment in frail older adults.
Review
Nutrition & Dietetics
Gaetano Santulli, Urna Kansakar, Fahimeh Varzideh, Pasquale Mone, Stanislovas S. Jankauskas, Angela Lombardi
Summary: Taurine, a naturally occurring sulfur-containing amino acid, has potential health benefits in aging and cardiovascular health, athletic performance, metabolic regulation, and neurological function. Evidence suggests that taurine may have positive effects on blood pressure regulation, cardiac fitness, and vascular health. Its mechanisms of action and antioxidant properties make it a promising candidate for anti-aging strategies. However, further research is needed on taurine intake and safety concerns.
Review
Biochemistry & Molecular Biology
Haikel Dridi, Gaetano Santulli, Laith Bahlouli, Marco C. Miotto, Gunnar Weninger, Andrew R. Marks
Summary: Heart failure is a global health challenge characterized by defective calcium handling, mitochondrial calcium overload, and oxidative stress. Calcium not only regulates contraction in cardiomyocytes, but also affects mitochondrial metabolism and oxidative stress signaling. Understanding the mechanisms of mitochondrial calcium uptake and the regulation of increased calcium influx is crucial for identifying therapeutic targets for heart failure.
Article
Cardiac & Cardiovascular Systems
Jessica Gambardella, Stanislovas S. Jankauskas, Urna Kansakar, Fahimeh Varzideh, Roberta Avvisato, Nella Prevete, Simone Sidoli, Pasquale Mone, Xujun Wang, Angela Lombardi, Gaetano Santulli
Summary: This study conducted comprehensive in vivo and in vitro experiments to investigate the molecular processes underlying ischemic cardiac disease. The findings revealed a specific pattern of chromatin remodeling induced by ischemic injury, which led to the transcriptional repression of a key regulator of mitochondrial function. Additionally, the study discovered a novel pathway linking metabolism to gene expression, demonstrating the role of ketone bodies in modulating chromatin remodeling and mitochondrial dysfunction.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
