Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

(2020) Amy S. Espeseth et al.   npj Vaccines

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

(2020) Dorottya Laczkó et al.   IMMUNITY

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

(2020) Kizzmekia S. Corbett et al.   NEW ENGLAND JOURNAL OF MEDICINE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

(2020) Sang Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization

(2020) Drew Weissman et al.   Cell Host & Microbe

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

(2019) Robert A. Feldman et al.   VACCINE

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Imaging the early fate of mRNA vaccines

(2019) Sebastian Ols et al.   Nature Biomedical Engineering

Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

(2019) Kevin E. Lindsay et al.   Nature Biomedical Engineering

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

(2019) Nurgun Kose et al.   Science Immunology

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Novel Vaccine Technologies

(2018) Barney S. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

(2018) Shinu John et al.   VACCINE

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

(2018) Jesse H. Erasmus et al.   MOLECULAR THERAPY

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

(2017) Michelle Meyer et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

(2017) Frank Liang et al.   Science Translational Medicine

Type I Interferons Modulate CD8 + T Cell Immunity to mRNA Vaccines

(2017) Ans De Beuckelaer et al.   TRENDS IN MOLECULAR MEDICINE

A thermostable messenger RNA based vaccine against rabies

(2017) Lothar Stitz et al.   PLoS Neglected Tropical Diseases

Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells

(2017) Gustaf Lindgren et al.   Frontiers in Immunology

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

(2017) Johannes Lutz et al.   npj Vaccines

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef

(2016) Rajesh T. Gandhi et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

(2016) Ans De Beuckelaer et al.   MOLECULAR THERAPY

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

(2016) Hok Hei Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Presentation to B Cells

(2016) Balthasar A. Heesters et al.   TRENDS IN IMMUNOLOGY

Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity

(2016) Aleksandra Kowalczyk et al.   VACCINE

An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs

(2016) Margit Schnee et al.   PLoS Neglected Tropical Diseases

CD8 T-cell priming upon mRNA vaccination is restricted to bone-marrow-derived antigen-presenting cells and may involve antigen transfer from myocytes

(2015) Sandra Lazzaro et al.   IMMUNOLOGY

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Induction of Cytomegalovirus-Specific T Cell Responses in Healthy Volunteers and Allogeneic Stem Cell Recipients Using Vaccination With Messenger RNA–Transfected Dendritic Cells

(2015) Amaryllis H. Van Craenenbroeck et al.   TRANSPLANTATION

Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization

(2015) Joseph R. Francica et al.   Nature Communications

RNA-Based Vaccines in Cancer Immunotherapy

(2015) Megan A. McNamara et al.   Journal of Immunology Research

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

(2014) William T. Shearer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

(2013) Armin Hekele et al.   Emerging Microbes & Infections

Type I IFN Drives a Distinctive Dendritic Cell Maturation Phenotype That Allows Continued Class II MHC Synthesis and Antigen Processing

(2012) D. P. Simmons et al.   JOURNAL OF IMMUNOLOGY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients

(2011) Ellen Van Gulck et al.   AIDS

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

(2011) Sabine D. Allard et al.   CLINICAL IMMUNOLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

(2009) Jean-Pierre Routy et al.   CLINICAL IMMUNOLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY