Homologous recombination and Mus81 promote replication completion in response to replication fork blockage

An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

(2020) Julia Bittmann et al.   eLife

Factors affecting template switch recombination associated with restarted DNA replication

(2019) Manisha Jalan et al.   eLife

Minimal Resection Takes Place during Break-Induced Replication Repair of Collapsed Replication Forks and Is Controlled by Strand Invasion

(2019) Kristoffer P. Jakobsen et al.   Cell Reports

Abortive activity of Topoisomerase I: a challenge for genome integrity?

(2019) Kristoffer Pors Jakobsen et al.   CURRENT GENETICS

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning

(2018) Luca Menin et al.   EMBO REPORTS

Break-Induced Replication: The Where, The Why, and The How

(2018) J. Kramara et al.   TRENDS IN GENETICS

Preserving replication fork integrity and competence via the homologous recombination pathway

(2018) Anissia Ait Saada et al.   DNA REPAIR

Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges

(2017) Anissia Ait Saada et al.   MOLECULAR CELL

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription

(2017) Alessandra Brambati et al.   NUCLEIC ACIDS RESEARCH

The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks

(2017) Ana Teixeira-Silva et al.   Nature Communications

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection

(2017) Karina Zadorozhny et al.   Cell Reports

Metnase Mediates Loading of Exonuclease 1 onto Single Strand Overhang DNA for End Resection at Stalled Replication Forks

(2016) Hyun-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 inSaccharomyces cerevisiae

(2016) Keiko Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast

(2016) Sabrina L. Andersen et al.   PLoS Genetics

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

(2015) Anderson T. Wang et al.   MOLECULAR CELL

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mus81 and converging forks limit the mutagenicity of replication fork breakage

(2015) R. Mayle et al.   SCIENCE

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage

(2015) Haiqing Fu et al.   Nature Communications

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

(2015) Najim Ameziane et al.   Nature Communications

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

(2015) Maxim Y Balakirev et al.   eLife

Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse

(2015) Michael O Nguyen et al.   eLife

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

(2014) Julian Stingele et al.   CELL

Chromosome rearrangements via template switching between diverged repeated sequences

(2014) Ranjith P. Anand et al.   GENES & DEVELOPMENT

The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins

(2014) E. Tsang et al.   JOURNAL OF CELL SCIENCE

Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability

(2014) Miguel G. Blanco et al.   MOLECULAR CELL

The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

(2014) Christie L. Eissler et al.   MOLECULAR CELL

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

The rem Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to Xeroderma pigmentosum-Cockayne Syndrome-Like Phenotypes

(2014) Emilia Herrera-Moyano et al.   PLoS Genetics

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

(2013) M. Yekezare et al.   JOURNAL OF CELL SCIENCE

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

(2013) Marenda A. Wilson et al.   NATURE

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Break-induced replication occurs by conservative DNA synthesis

(2013) R. A. Donnianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Break-Induced DNA Replication

(2013) R. P. Anand et al.   Cold Spring Harbor Perspectives in Biology

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid

(2013) Sandra Muñoz-Galván et al.   PLoS Genetics

Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing

(2012) Julien N. Bianco et al.   METHODS

Mus81-Mms4 Functions as a Single Heterodimer To Cleave Nicked Intermediates in Recombinational DNA Repair

(2012) E. K. Schwartz et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange

(2012) S. Munoz-Galvan et al.   MOLECULAR AND CELLULAR BIOLOGY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4

(2012) María Gallo-Fernández et al.   NUCLEIC ACIDS RESEARCH

Recovery of Arrested Replication Forks by Homologous Recombination Is Error-Prone

(2012) Ismail Iraqui et al.   PLoS Genetics

Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases

(2012) Benjamin Pardo et al.   PLoS Genetics

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

(2011) Marie Regairaz et al.   JOURNAL OF CELL BIOLOGY

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage

(2011) S. S. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

Mismatch Repair, But Not Heteroduplex Rejection, Is Temporally Coupled to DNA Replication

(2011) H. Hombauer et al.   SCIENCE

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

Replication fork breakage and re-start: New insights into Rad3/XPD-associated deficiencies

(2010) M. Moriel-Carretero et al.   CELL CYCLE

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae

(2010) Miguel G. Blanco et al.   DNA REPAIR

Overlapping Roles for Yen1 and Mus81 in Cellular Holliday Junction Processing

(2010) Ye Dee Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

A Postincision-Deficient TFIIH Causes Replication Fork Breakage and Uncovers Alternative Rad51- or Pol32-Mediated Restart Mechanisms

(2010) María Moriel-Carretero et al.   MOLECULAR CELL

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

(2010) Laura Kapitzky et al.   Molecular Systems Biology

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

(2010) M. J. Lippert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

(2010) T. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal Translocations Caused by Either Pol32-Dependent or Pol32-Independent Triparental Break-Induced Replication

(2009) J. F. Ruiz et al.   MOLECULAR AND CELLULAR BIOLOGY

A Flp-nick system to study repair of a single protein-bound nick in vivo

(2009) Ida Nielsen et al.   NATURE METHODS

A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4

(2009) Kirk Tevebaugh Ehmsen et al.   NUCLEIC ACIDS RESEARCH

Mus81 is essential for sister chromatid recombination at broken replication forks

(2008) Laura Roseaulin et al.   EMBO JOURNAL