Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol‐dependent manner

Cholesterol induces epithelial-to-mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP

(2019) Siyuan jiang et al.   CANCER RESEARCH

An update on synthetic high-density lipoprotein-like nanoparticles for cancer therapy

(2019) Stephen E. Henrich et al.   Expert Review of Anticancer Therapy

Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

(2019) Jinlu Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases

(2018) Jonathan S. Rink et al.   ACS Applied Materials & Interfaces

Transverse distribution of plasma membrane bilayer cholesterol: Picking sides

(2018) Theodore L. Steck et al.   TRAFFIC

Bone Marrow Fat and Hematopoiesis

(2018) Huifang Wang et al.   Frontiers in Endocrinology

Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells

(2017) Michael P. Plebanek et al.   MOLECULAR CANCER THERAPEUTICS

Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia

(2017) E J Gallagher et al.   ONCOGENE

Exosomes: Key mediators of metastasis and pre-metastatic niche formation

(2017) Richard J. Lobb et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

(2017) Michael P. Plebanek et al.   Nature Communications

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer

(2016) Steven Kregel et al.   Oncotarget

Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts

(2015) Noriko Takegahara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake

(2015) Michael P. Plebanek et al.   Scientific Reports

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

(2014) Amy Chow et al.   Scientific Reports

Understanding and Targeting Osteoclastic Activity in Prostate Cancer Bone Metastases

(2013) J.L. Sottnik et al.   CURRENT MOLECULAR MEDICINE

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomimetic, synthetic HDL nanostructures for lymphoma

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Marrow–Derived Gr1 + Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1

(2013) Raúl Catena et al.   Cancer Discovery

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

(2012) Tara Karnezis et al.   CANCER CELL

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

(2012) Clifford J. Rosen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery

(2012) Christian E Jacome-Galarza et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins

(2012) Ren Sheng et al.   Nature Communications

Structural Characterization of the Caveolin Scaffolding Domain in Association with Cholesterol-Rich Membranes

(2011) Cody L. Hoop et al.   BIOCHEMISTRY

Low levels of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the Swedish AMORIS study

(2011) Mieke Van Hemelrijck et al.   CANCER CAUSES & CONTROL

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial

(2011) Matthew R Smith et al.   LANCET

Spatial organization of transmembrane receptor signalling

(2010) Ioanna Bethani et al.   EMBO JOURNAL

Cholesterol Induces Specific Spatial and Orientational Order in Cholesterol/Phospholipid Membranes

(2010) Hector Martinez-Seara et al.   PLoS One

Metabolomic Characterization of Human Prostate Cancer Bone Metastases Reveals Increased Levels of Cholesterol

(2010) Elin Thysell et al.   PLoS One

Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort

(2009) Alison M. Mondul et al.   CANCER CAUSES & CONTROL

Men with Low Serum Cholesterol Have a Lower Risk of High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial

(2009) E. A. Platz et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Circulating Tumor Cells and Bone Marrow Micrometastasis

(2008) C. Alix-Panabieres et al.   CLINICAL CANCER RESEARCH

Association between plasma cholesterol and prostate cancer in the PSA era

(2008) Elizabeth A. Platz et al.   INTERNATIONAL JOURNAL OF CANCER

Osteoclasts Are Active in Bone Forming Metastases of Prostate Cancer Patients

(2008) Ilaria Roato et al.   PLoS One