Review
Oncology
Laura Patras, Doru Paul, Irina R. Matei
Summary: The discovery of the pre-metastatic niche (PMN) formation, where primary tumors condition distant organ sites for future metastasis, has revolutionized our understanding of cancer progression and provided new avenues for therapeutic interventions. The remodeling of the extracellular matrix (ECM) in the distal organ is the initiating event in PMN development, facilitated by primary tumor-secreted factors and orchestrated through crosstalk between various resident and recruited cells. This review explores the ECM changes, cellular effectors, and mechanisms of ECM remodeling in PMN progression, highlighting the clinical implications and therapeutic opportunities for targeting the ECM to hinder PMN formation.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Jin Cheng, Kun Zhang, Chunhui Qu, Jinwu Peng, Lifang Yang
Summary: Metastasis is a critical stage of tumor progression, and recent studies have shown that extracellular vesicles (EVs) play an important role in the formation of the pre-metastatic niche (PMN).
Review
Biochemistry & Molecular Biology
Lionel Gillot, Louis Baudin, Loic Rouaud, Frederic Kridelka, Agnes Noel
Summary: Lymph node metastasis is a significant prognostic factor in various cancers, serving as a gateway for further dissemination. Prior to metastasis, the primary tumor reshapes the draining lymph node by secreting soluble factors or releasing extracellular vesicles, creating a pre-metastatic niche for the survival and growth of metastatic cells. This review highlights the structure of lymph nodes, matrix composition, cellular heterogeneity, and major processes associated with nodal pre-metastatic niche formation, offering insights into potential research directions and clinical implications.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Xinxin Yuan, Niansong Qian, Shukuan Ling, Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Guohui Zhong, Caizhi Liu, Guotao Yu, Dengchao Cao, Zizhong Liu, Yinbo Wang, Zhihong Qi, Yingpeng Yao, Fang Wang, Jingjing Liu, Shanshan Hao, Xiaoyan Jin, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Xingcheng Gao, Shuai Liang, Youyou Li, Jinping Song, Shuyang Yu, Yingxian Li
Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.
Review
Biochemistry & Molecular Biology
Theresa Akoto, Sharanjot Saini
Summary: Prostate cancer is a life-threatening disease among men globally, with metastasis being the major cause of mortality. Cell-to-cell communication plays a crucial role in the progression and metastasis of prostate cancer, with exosomes/extracellular vesicles demonstrating significant involvement in signaling pathways related to metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Benjamin Ormseth, Amblessed Onuma, Hongji Zhang, Allan Tsung
Summary: The pre-metastatic niche (PMN) is a targeted therapy that prevents cancer metastasis before it occurs. The communication between primary tumors and the liver establishes a microenvironment that increases susceptibility to tumor cell invasion and outgrowth. Understanding the mechanisms of the PMN could provide opportunities for clinical intervention and potentially serve as biomarkers.
Article
Cell Biology
Laurence Blavier, Rie Nakata, Paolo Neviani, Khounish Sharma, Hiroyuki Shimada, Aitor Benedicto, Irina Matei, David Lyden, Yves A. DeClerck
Summary: The capture of tumour-derived extracellular vesicles (TEVs) by cells in the tumour microenvironment (TME) contributes to metastasis and notably to the formation of the pre-metastatic niche (PMN). However, due to the challenges associated with modelling release of small EVs in vivo, the kinetics of PMN formation in response to endogenously released TEVs have not been examined. Here, we have studied the endogenous release of TEVs in mice orthotopically implanted with metastatic human melanoma (MEL) and neuroblastoma (NB) cells releasing GFP-tagged EVs (GFTEVs) and their capture by host cells to demonstrate the active contribution of TEVs to metastasis.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Pharmacology & Pharmacy
Yuping Liu, Dengxuan Mao, Hong Wang, Xiaoyu Che, Yan Chen
Summary: Tumor cells-derived EVs play a crucial role in the formation of PMN in the lung and can potentially be utilized as a target or carrier for the intervention of lung PMN.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Seyedeh Alia Moosavian, Maryam Hashemi, Leila Etemad, Sara Daneshmand, Zahra Salmasi
Summary: Exosomes play a crucial role in early diagnosis and various functions related to angiogenesis, immune modulation, migration, metastasis, chemotherapy resistance, and tumor progression in melanoma. Natural exosomes have the potential to be utilized as nanocarriers and cancer vaccines for more efficient cancer treatment in the era of novel bioengineering and immunotherapy approaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xuyang Yang, Yang Zhang, Yaguang Zhang, Su Zhang, Lei Qiu, Zixuan Zhuang, Mingtian Wei, Xiangbing Deng, Ziqiang Wang, Junhong Han
Summary: Exosomes released from cells transfer bio-information to recipient cells, particularly in the context of tumor pre-metastatic niche (PMN) formation, facilitating tumor cell colonization and metastasis. These exosomes induce epigenetic changes in target cells, contributing to the formation of PMN.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Alberto Carretero-Gonzalez, Marta Hergueta-Redondo, Sara Sanchez-Redondo, Pilar Ximenez-Embun, Luis Manso Sanchez, Eva Ciruelos Gil, Daniel Castellano, Guillermo de Velasco, Hector Peinado
Summary: Brain metastases occur in nearly 40% of advanced cancer patients and are associated with poor prognosis. Liquid biopsy using extracellular vesicles (EVs) as biomarkers allows for noninvasive monitoring of brain metastases. This study found that decreased STAT3 activation and increased PD-L1 levels in plasma circulating EVs are associated with brain metastases in melanoma patients.
Review
Oncology
M. C. Sanmartin, F. R. Borzone, M. B. Giorello, N. Pacienza, G. Yannarelli, N. A. Chasseing
Summary: Breast cancer, a common pathology in women, often leads to bone metastases with high mortality. Research shows that breast cancer cells prepare a pre-metastatic niche for colonization in the future. While the role of different cellular components in bone metastasis is well described, studying the changes in the microenvironment before tumor cells arrive is a novel field of research.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Akira Yokoi, Takahiro Ochiya
Summary: This review summarizes recent studies on EVs from the perspective of EV heterogeneity and highlights their role in various steps from oncogenic to metastatic processes. Recognizing EV subtypes is crucial for identifying pathways affected by EVs and targeting specific subtypes in therapeutic approaches or liquid biopsies.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eduardo Duran-Jara, Tamara Vera-Tobar, Lorena De Lourdes Lobos-Gonzalez
Summary: Lactadherin is associated with cancer development and progression, and can serve as a biomarker and therapeutic target for cancer. It plays important roles in cell adhesion, angiogenesis, and tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Zhenzhen Mo, Jia Yang Alex Cheong, Lirong Xiang, Minh T. N. Le, Andrew Grimson, Daniel Xin Zhang
Summary: Metastasis, the dissemination of primary tumor cells, is a major cause of cancer-related deaths. Metastatic organotropism, the specific distribution pattern of distant metastasis, is influenced by various factors. Extracellular vesicles (EVs) play a crucial role in organ-specific metastasis, carrying bioactive cargo that can modulate the pre-metastatic niche and influencing diagnostic and prognostic values. Counteracting EV functions could be a novel therapeutic strategy to target metastasis. More research is needed to understand the mechanisms of EVs in organ-specific metastasis for clinical translation.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C. Shad Thaxton
JOURNAL OF LIPID RESEARCH
(2015)
Article
Chemistry, Multidisciplinary
Kaylin M. McMahon, Michael P. Plebanek, Colby Shad Thaxton
ADVANCED FUNCTIONAL MATERIALS
(2016)
Article
Chemistry, Physical
Wangqiang Sun, Weiqiang Wu, Kaylin M. McMahon, Jonathan S. Rink, C. Shad Thaxton
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2016)
Article
Medicine, Research & Experimental
Jonathan S. Rink, Shuo Yang, Osman Cen, Tim Taxter, Kaylin M. McMahon, Sol Misener, Amir Behdad, Richard Longnecker, Leo I. Gordon, C. Shad Thaxton
MOLECULAR PHARMACEUTICS
(2017)
Article
Oncology
Andrea E. Murmann, Kaylin M. McMahon, Ashley Haluck-Kangas, Nandini Ravindran, Monal Patel, Calvin Y. Law, Sonia Brockway, Jian-Jun Wei, C. Shad Thaxton, Marcus E. Peter
Article
Oncology
Kaylin M. McMahon, Cristina Scielzo, Nicholas L. Angeloni, Elad Deiss-Yehiely, Lydia Scarfo, Pamela Ranghetti, Shuo Ma, Jason Kaplan, Federica Barbaglio, Leo I. Gordon, Francis J. Giles, C. Shad Thaxton, Paolo Ghia
Article
Biochemistry & Molecular Biology
Andrea E. Murmann, Quan Q. Gao, William E. Putzbach, Monal Patel, Elizabeth T. Bartom, Calvin Y. Law, Bryan Bridgeman, Siquan Chen, Kaylin M. McMahon, C. Shad Thaxton, Marcus E. Peter
Article
Chemistry, Physical
Sushant Tripathy, Elena Vinokour, Kaylin M. McMahon, Olga V. Volpert, C. Shad Thaxton
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2014)
Article
Multidisciplinary Sciences
Tiffany L. Halo, Kaylin M. McMahon, Nicholas L. Angeloni, Yilin Xu, Wei Wang, Alyssa B. Chinen, Dmitry Malin, Elena Strekalova, Vincent L. Cryns, Chonghui Cheng, Chad A. Mirkin, C. Shad Thaxton
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Multidisciplinary Sciences
Nicholas L. Angeloni, Kaylin M. McMahon, Suchitra Swaminathan, Michael P. Plebanek, Iman Osman, Olga V. Volpert, C. Shad Thaxton
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Multidisciplinary
Kaylin M. McMahon, Andrea E. Calvert, Irina S. Dementieva, Saber Hussain, John T. Wilkins, C. Shad Thaxton
Review
Ophthalmology
Robert M. Lavker, Nihal Kaplan, Kaylin M. McMahon, Andrea E. Calvert, Stephen E. Henrich, Ummiye Onay, Kurt Q. Lu, Han Peng, C. Shad Thaxton
Summary: Medicine has greatly benefited from the nanotechnology revolution, particularly in the development of bio-nanoparticles like synthetic high-density lipoprotein (HDL) nanoparticles for treating ocular diseases. These HDL nanoparticles mimic natural HDLs, bind with receptors, are non-toxic, and can deliver microRNAs effectively. Their translational potential in the form of topical eye drops highlights the impact nanoparticles can have in medicine.
Article
Pharmacology & Pharmacy
Junyi Wang, Andrea E. Calvert, Nihal Kaplan, Kaylin M. McMahon, Wending Yang, Kurt Q. Lu, Han Peng, Colby Shad Thaxton, Robert M. Lavker
ADVANCED THERAPEUTICS
(2020)
Article
Chemistry, Physical
Vikas Nandwana, Soo-Ryoon Ryoo, Shanthi Kanthala, Kaylin M. McMahon, Jonathan S. Rink, Yue Li, Subbu S. Venkatraman, C. Shad Thaxton, Vinayak P. Dravid
CHEMISTRY OF MATERIALS
(2017)