Engineered biomimetic platelet membrane-coated nanoparticles block staphylococcus aureus cytotoxicity and protect against lethal systemic infection

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Modulation of Immune Responses by Platelet-Derived ADAM10

(2020) Stefanie Maurer et al.   Frontiers in Immunology

Biomimetic Nanosponges Suppress In Vivo Lethality Induced by the Whole Secreted Proteins of Pathogenic Bacteria

(2019) Yijie Chen et al.   Small

Neutrophil Extracellular Traps Enhance Staphylococcus Aureus Vegetation Formation through Interaction with Platelets in Infective Endocarditis

(2019) Chih-Chieh Hsu et al.   THROMBOSIS AND HAEMOSTASIS

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

(2019) Nicholas A. Turner et al.   NATURE REVIEWS MICROBIOLOGY

Human platelets and megakaryocytes express defensin alpha 1

(2019) Xareni Valle-Jiménez et al.   PLATELETS

Regulation of Innate Immune Responses by Platelets

(2019) Lucas Secchim Ribeiro et al.   Frontiers in Immunology

Platelets and Intravascular Immunity: Guardians of the Vascular Space During Bloodstream Infections and Sepsis

(2019) Braedon McDonald et al.   Frontiers in Immunology

DAMPs and NETs in Sepsis

(2019) Naomi-Liza Denning et al.   Frontiers in Immunology

Platelets and platelet extracellular vesicles in hemostasis and sepsis

(2019) Elizabeth W J Kerris et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

(2018) Bas G.J. Surewaard et al.   Cell Host & Microbe

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets

(2018) Zeki Ilkan et al.   THROMBOSIS AND HAEMOSTASIS

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

(2018) Joachim Pircher et al.   Nature Communications

Start a fire, kill the bug: The role of platelets in inflammation and infection

(2018) Carsten Deppermann et al.   Innate Immunity

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

(2018) Jan Rossaint et al.   Frontiers in Immunology

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

(2017) Soracha Thamphiwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity

(2017) E. Sachiko Seilie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Red Blood Cell Membrane-Camouflaged Nanoparticle Counteracts Streptolysin O-Mediated Virulence Phenotypes of Invasive Group A Streptococcus

(2017) Tamara Escajadillo et al.   Frontiers in Pharmacology

Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia

(2016) Xiaoli Wei et al.   BIOMATERIALS

Engineered nanoparticles mimicking cell membranes for toxin neutralization

(2015) Ronnie H. Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Hydrogel Retaining Toxin-Absorbing Nanosponges for Local Treatment of Methicillin-ResistantStaphylococcus aureusInfection

(2015) Fei Wang et al.   ADVANCED MATERIALS

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

(2015) Steven Y. C. Tong et al.   CLINICAL MICROBIOLOGY REVIEWS

Pyroptosis of resident macrophages differentially orchestrates inflammatory responses toStaphylococcus aureusin resistant and susceptible mice

(2015) Solène Accarias et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets

(2015) Agostina Carestia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Surviving sepsis in the era of antibiotic resistance: Are there any alternative approaches to antibiotic therapy?

(2015) Divakara S.S.M. Uppu et al.   MICROBIAL PATHOGENESIS

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

The inflammatory role of platelets via their TLRs and Siglec receptors

(2015) Fabrice Cognasse   Frontiers in Immunology

Are Platelets Cells? And if Yes, are They Immune Cells?

(2015) Olivier Garraud et al.   Frontiers in Immunology

A novel conditional platelet depletion mouse model reveals the importance of platelets in protection againstStaphylococcus aureusbacteremia

(2014) L. M. Wuescher et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice

(2014) Brian D Henry et al.   NATURE BIOTECHNOLOGY

Lipopolysaccharide Stimulates Platelets through an IL-1  Autocrine Loop

(2013) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Platelet-macrophage partnership in innate immunity and inflammation

(2013) Alberto Mantovani et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

A biomimetic nanosponge that absorbs pore-forming toxins

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

P2Y 12 Receptor Blockade Augments Glycoprotein IIb‐IIIa Antagonist Inhibition of Platelet Activation, Aggregation, and Procoagulant Activity

(2013) Michelle A. Berny‐Lang et al.   Journal of the American Heart Association

The potential use of toxin antibodies as a strategy for controlling acuteStaphylococcus aureusinfections

(2012) Gordon YC Cheung et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Native Thrombocidin-1 and Unfolded Thrombocidin-1 Exert Antimicrobial Activity via Distinct Structural Elements

(2011) Paulus H. S. Kwakman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet Antistaphylococcal Responses Occur through P2X1 and P2Y12 Receptor-Induced Activation and Kinocidin Release

(2008) D. A. Trier et al.   INFECTION AND IMMUNITY