Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Beyond IgE: Alternative Mast Cell Activation Across Different Disease States

(2020) David O. Lyons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MRGPRX2 Activation Causes Increased Skin Reactivity in Chronic Spontaneous Urticaria Patients

(2020) Maria Shtessel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis?

(2020) Zhao Wang et al.   EXPERIMENTAL DERMATOLOGY

Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies

(2020) Helen Kühn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MRGPRX2 is the codeine receptor of human skin mast cells: desensitization via β-arrestin and lack of correlation with the FcεRI pathway

(2020) Magda Babina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

(2019) Mohammad Arifuzzaman et al.   Science Advances

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

(2019) Dustin P. Green et al.   NEURON

Yin-yang of IL-33 in human skin mast cells: reduced degranulation, but augmented histamine synthesis through p38 activation

(2019) Magda Babina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TSLP production induced by skin irritation results from the concomitant activation of PAR ‐2 and IL ‐1 pathways

(2019) D. Redhu et al.   BRITISH JOURNAL OF DERMATOLOGY

IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

(2019) Zhao Wang et al.   Cells

A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

(2019) Priyanka Pundir et al.   Cell Host & Microbe

Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions

(2019) Elin Rönnberg et al.   Frontiers in Immunology

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

(2019) Hanna Siiskonen et al.   Frontiers in Cellular Neuroscience

Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL

(2019) Tarek Hazzan et al.   Cells

Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P

(2019) Chalatip Chompunud Na Ayudhya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The JAK1/JAK2- inhibitor ruxolitinib inhibits mast cell degranulation and cytokine release

(2018) M.A.W. Hermans et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Pathophysiology of Eosinophilic Esophagitis

(2018) Kelly M. O’Shea et al.   GASTROENTEROLOGY

Non-IgE mediated mast cell activation

(2018) Frank A. Redegeld et al.   IMMUNOLOGICAL REVIEWS

Role of mast cells and basophils in pruritus

(2018) Martin Steinhoff et al.   IMMUNOLOGICAL REVIEWS

Mast cell activation test in the diagnosis of allergic disease and anaphylaxis

(2018) Rajia Bahri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast cells signal their importance in health and disease

(2018) Ana Olivera et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MRGPRX2 is negatively targeted by SCF and IL-4 to diminish pseudo-allergic stimulation of skin mast cells in culture

(2018) Magda Babina et al.   EXPERIMENTAL DERMATOLOGY

MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia

(2018) Arnau Navinés-Ferrer et al.   Scientific Reports

Tezepelumab, an anti-TSLP monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial

(2018) Eric L. Simpson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions

(2018) Grzegorz Porebski et al.   Frontiers in Immunology

An efficient method for gene knock-down by RNA interference in human skin mast cells

(2017) Tarek Hazzan et al.   EXPERIMENTAL DERMATOLOGY

Skin mast cell phenotypes between two highly divergent cohorts - more pronounced variability within than between groups

(2017) Magda Babina et al.   EXPERIMENTAL DERMATOLOGY

Retinoic Acid Negatively Impacts Proliferation and MCTC Specific Attributes of Human Skin Derived Mast Cells, but Reinforces Allergic Stimulability

(2017) Magda Babina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level

(2017) Régis Joulia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In silico design of novel probes for the atypical opioid receptor MRGPRX2

(2017) Katherine Lansu et al.   Nature Chemical Biology

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

FANTOM5 CAGE profiles of human and mouse samples

(2017) Shuhei Noguchi et al.   Scientific Data

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story

(2016) J. Bousquet et al.   ALLERGY

Mast Cells and Anaphylaxis

(2016) Phil Lieberman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells

(2016) Yangyang Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IL-33 and Thymic Stromal Lymphopoietin in mast cell functions

(2016) Rohit Saluja et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phenotypic variability in human skin mast cells

(2016) Magda Babina et al.   EXPERIMENTAL DERMATOLOGY

Thymic stromal lymphopoietin controls prostaglandin D 2 generation in patients with aspirin-exacerbated respiratory disease

(2016) Kathleen M. Buchheit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

(2016) Hariharan Subramanian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different activation signals induce distinct mast cell degranulation strategies

(2016) Nicolas Gaudenzio et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic stromal lymphopoietin induction by skin irritation is independent of tumour necrosis factor-α, but supported by interleukin-1

(2015) V. Kumari et al.   BRITISH JOURNAL OF DERMATOLOGY

Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous (‘idiopathic’) urticaria

(2015) A.B. Kay et al.   BRITISH JOURNAL OF DERMATOLOGY

Retinoic acid potentiates inflammatory cytokines in human mast cells: Identification of mast cells as prominent constituents of the skin retinoid network

(2015) Magda Babina et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

(2014) E. Motakis et al.   BLOOD

Skin mast cells develop non-synchronized changes in typical lineage characteristics upon culture

(2014) Sven Guhl et al.   EXPERIMENTAL DERMATOLOGY

The importance of TSLP in allergic disease and its role as a potential therapeutic target

(2014) Antonella Cianferoni et al.   Expert Review of Clinical Immunology

Thymic stromal lymphopoietin links keratinocytes and dendritic cell–derived IL-23 in patients with psoriasis

(2014) Elisabetta Volpe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

(2014) Mario Noti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria

(2014) Daisuke Fujisawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TSLP Induces Mast Cell Development and Aggravates Allergic Reactions through the Activation of MDM2 and STAT6

(2014) Na-Ra Han et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

A promoter-level mammalian expression atlas

(2014)   NATURE

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

(2014) Tomoaki Ando et al.   Cell Reports

Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

(2013) Weiguo Yao et al.   IMMUNITY

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

(2013) Bryan D Bell et al.   NATURE IMMUNOLOGY

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

(2013) Hiroki Kabata et al.   Nature Communications

Allergen Recognition by Innate Immune Cells: Critical Role of Dendritic and Epithelial Cells

(2013) Fabián Salazar et al.   Frontiers in Immunology

Mast Cell-Activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34+ Progenitor Cells

(2013) Zoulfia Allakhverdi et al.   Frontiers in Immunology

IL-33/ST2 axis in inflammation and immunopathology

(2012) Marija Milovanovic et al.   IMMUNOLOGIC RESEARCH

Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin

(2012) Deepti R. Nagarkar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin and allergic disease

(2012) Steven F. Ziegler   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Long-Term Cultured Human Skin Mast Cells Are Suitable for Pharmacological Studies of Anti-Allergic Drugs Due to High Responsiveness to FcεRI Cross-Linking

(2011) Sven GUHL et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mast Cell-Airway Smooth Muscle Crosstalk

(2011) Davinder Kaur et al.   CHEST

Novel Mechanism for FcϵRI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production

(2011) Nicholas A. Pullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asthma and Allergic Inflammation

(2010) Richard M. Locksley   CELL

Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation

(2010) Ferenc A. Scheeren et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic Stromal Lymphopoietin Receptor-Mediated IL-6 and CC/CXC Chemokines Expression in Human Airway Smooth Muscle Cells: Role of MAPKs (ERK1/2, p38, and JNK) and STAT3 Pathways

(2010) L. Shan et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Peptides Human  -Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

(2010) F. Niyonsaba et al.   JOURNAL OF IMMUNOLOGY

Sensing the outside world: TSLP regulates barrier immunity

(2010) Steven F Ziegler et al.   NATURE IMMUNOLOGY

JNK1 controls mast cell degranulation and IL-1  production in inflammatory arthritis

(2010) M. Guma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cells in atopic dermatitis

(2009) Toshiaki Kawakami et al.   CURRENT OPINION IN IMMUNOLOGY

The tyrosine kinase network regulating mast cell activation

(2009) Alasdair M. Gilfillan et al.   IMMUNOLOGICAL REVIEWS

Mechanisms of mast cell signaling in anaphylaxis

(2009) Dean D. Metcalfe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mast cells and mastocytosis

(2008) D. D. Metcalfe   BLOOD