High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome

A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness

(2015) Julia M. Coppola et al.   NEOPLASIA

The modular serine proteases of the complement cascade

(2012) Federico Forneris et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Two functional domains in C. elegans glypican LON-2 can independently inhibit BMP-like signaling

(2012) Suparna Taneja-Bageshwar et al.   DEVELOPMENTAL BIOLOGY

The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis

(2012) P. Fortugno et al.   HUMAN MOLECULAR GENETICS

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

(2012) Gero L. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death

(2012) W. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

New Details of HCV NS3/4A Proteinase Functionality Revealed by a High-Throughput Cleavage Assay

(2012) Sergey A. Shiryaev et al.   PLoS One

A Highly Scalable Peptide-Based Assay System for Proteomics

(2012) Igor A. Kozlov et al.   PLoS One

What lies ahead for the proprotein convertases?

(2011) Nabil G. Seidah   Annals of the New York Academy of Sciences

Identification of proprotein convertase substrates using genome-wide expression correlation analysis

(2011) Hannu Turpeinen et al.   BMC GENOMICS

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain

(2011) Marie Bidart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs

(2011) Sun Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Latent Transforming Growth Factor β-Binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A

(2011) Xiaowei Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Processing of Angiopoietin-like Protein 4 by Proprotein Convertases Modulates Its Inhibitory Effects on Lipoprotein Lipase Activity

(2011) Xia Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of Limited Proteolysis

(2011) Marat D. Kazanov et al.   JOURNAL OF PROTEOME RESEARCH

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

FFAS server: novel features and applications

(2011) L. Jaroszewski et al.   NUCLEIC ACIDS RESEARCH

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

A Femtomol Range FRET Biosensor Reports Exceedingly Low Levels of Cell Surface Furin: Implications for the Processing of Anthrax Protective Antigen

(2010) Katarzyna Gawlik et al.   PLoS One

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Autocatalytic Activation of the Furin Zymogen Requires Removal of the Emerging Enzyme's N-Terminus from the Active Site

(2009) Katarzyna Gawlik et al.   PLoS One

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

(2009) Wendy R. Gordon et al.   PLoS One

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

(2008) John et al.   Frontiers in Bioscience-Landmark

Substrate Cleavage Analysis of Furin and Related Proprotein Convertases

(2008) Albert G. Remacle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accurate whole human genome sequencing using reversible terminator chemistry

(2008) David R. Bentley et al.   NATURE