Perinatal Brain Injury and Inflammation: Lessons from Experimental Murine Models

White matter injury after neonatal encephalopathy is associated with thalamic metabolite perturbations

(2020) Paolo Montaldo et al.   EBioMedicine

Neuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury

(2020) Mengya Jiao et al.   Journal of Neuroinflammation

Early Pro-inflammatory Microglia Activation After Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats

(2019) Meray Serdar et al.   Frontiers in Cellular Neuroscience

Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management

(2019) Saima Aslam et al.   Frontiers in Pediatrics

The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia

(2019) Sean Quinlan et al.   Frontiers in Immunology

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity

(2019) Zhen Tang et al.   EXPERIMENTAL NEUROLOGY

TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain

(2019) Xin Wang et al.   Journal of Neuroinflammation

LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats

(2019) Clivandir Severino da Silva et al.   Frontiers in Behavioral Neuroscience

Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

(2019) Serena Pellegrin et al.   VACCINE

Inflammatory Responses are Sex Specific in Chronic Hypoxic–Ischemic Encephalopathy

(2018) Abdullah Al Mamun et al.   CELL TRANSPLANTATION

Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons

(2018) Nour Al-Muhtasib et al.   EPILEPSIA

Microglia and Neonatal Brain Injury

(2018) Carina Mallard et al.   NEUROSCIENCE

Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures

(2018) Sean M. M. Quinlan et al.   Scientific Reports

Mesenchymal stem cells-derived IL-6 activates AMPK/mTOR signaling to inhibit the proliferation of reactive astrocytes induced by hypoxic-ischemic brain damage

(2018) Mulan He et al.   EXPERIMENTAL NEUROLOGY

Peripheral myeloid cells contribute to brain injury in male neonatal mice

(2018) Peter L. P. Smith et al.   Journal of Neuroinflammation

Interleukin-10 release from astrocytes suppresses neuronal apoptosis via the TLR2/NFκB pathway in a neonatal rat model of hypoxic-ischemic brain damage

(2017) Mu Lan He et al.   JOURNAL OF NEUROCHEMISTRY

Children born at 32 to 35 weeks with birth asphyxia and later cerebral palsy are different from those born after 35 weeks

(2017) J Garfinkle et al.   Journal of Perinatology

Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model

(2017) Luc Morin et al.   NEUROBIOLOGY OF DISEASE

Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice

(2017) Natalia Rodriguez-Alvarez et al.   NEUROPHARMACOLOGY

Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders

(2017) Amin Mottahedin et al.   Frontiers in Cellular Neuroscience

TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus

(2017) Joaquin I. Hurtado-Zavala et al.   Nature Communications

Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort

(2016) Tracy A. Manuck et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior

(2016) Silvia Honda Takada et al.   BEHAVIOURAL BRAIN RESEARCH

Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus

(2016) Katalin Rozmer et al.   CEREBRAL CORTEX

Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives

(2016) Maria D. Donovan et al.   DRUGS

Phenobarbital for Neonatal Seizures: Response Rate and Predictors of Refractoriness

(2016) Stefano Seri et al.   NEUROPEDIATRICS

Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte

(2016) Yan Gu et al.   Scientific Reports

Characterization of mitochondrial bioenergetics in neonatal anoxic model of rats

(2015) Puneet K. Samaiya et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats

(2015) Chia-Ti Wang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial

(2015) Ronit M Pressler et al.   LANCET NEUROLOGY

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice

(2015) Natalia Rodriguez-Alvarez et al.   NEUROBIOLOGY OF DISEASE

Neonatal Seizures: A Review of Outcomes and Outcome Predictors

(2015) Francesco Pisani et al.   NEUROPEDIATRICS

Neonatal anoxia in rats: Hippocampal cellular and subcellular changes related to cell death and spatial memory

(2015) S.H. Takada et al.   NEUROSCIENCE

Flupirtine effectively prevents development of acute neonatal seizures in an animal model of global hypoxia

(2015) Dayalan Sampath et al.   NEUROSCIENCE LETTERS

Seizures and hypothermia: Importance of electroencephalographic monitoring and considerations for treatment

(2015) Geraldine B. Boylan et al.   Seminars in Fetal & Neonatal Medicine

P2X receptors in maintenance and differentiation of neural progenitor cells

(2015) Henning Ulrich et al.   Neural Regeneration Research

P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage

(2014) Guillaume Mesuret et al.   CNS Neuroscience & Therapeutics

The immune response after hypoxia-ischemia in a mouse model of preterm brain injury

(2014) Anna-Maj Albertsson et al.   Journal of Neuroinflammation

Impact of transient acute hypoxia on the developing mouse EEG

(2014) S. Zanelli et al.   NEUROBIOLOGY OF DISEASE

Altered Astrocyte–Neuronal Interactions After Hypoxia-Ischemia in the Neonatal Brain in Female and Male Rats

(2014) Tora Sund Morken et al.   STROKE

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1

(2013) Zhifeng Peng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures

(2013) N L Maitre et al.   Journal of Perinatology

Neonatal lipopolysaccharide exposure induces long-lasting learning impairment, less anxiety-like response and hippocampal injury in adult rats

(2013) K.-C. Wang et al.   NEUROSCIENCE

Epidemiology and aetiology of neonatal seizures

(2013) Chakrapani Vasudevan et al.   Seminars in Fetal & Neonatal Medicine

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of epilepsy

(2012) Russell M. Sanchez et al.   EPILEPSIA

Learning and Cognitive Deficits in Hypoxic Neonatal Rats Intensified by BAX Mediated Apoptosis: Protective Role of Glucose, Oxygen, and Epinephrine

(2012) Anju Thoppil Raveendran et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Serum Cytokines in a Clinical Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy

(2012) Dorothea D Jenkins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Altered small-world topology of structural brain networks in infants with intrauterine growth restriction and its association with later neurodevelopmental outcome

(2012) Dafnis Batalle et al.   NEUROIMAGE

Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat

(2012) S.K. Bhardwaj et al.   NEUROPHARMACOLOGY

Evaluation of Etiologic and Prognostic Factors in Neonatal Convulsions

(2012) Edibe Pembegul Yıldız et al.   PEDIATRIC NEUROLOGY

Long Lasting Local and Systemic Inflammation after Cerebral Hypoxic ischemia in Newborn Mice

(2012) Max Winerdal et al.   PLoS One

Systemic inflammation disrupts the developmental program of white matter

(2011) Géraldine Favrais et al.   ANNALS OF NEUROLOGY

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants

(2011) Joshua R. Buser et al.   ANNALS OF NEUROLOGY

Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain

(2011) Patrick A. Forcelli et al.   EPILEPSIA

Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures

(2011) Sanjay N. Rakhade et al.   EPILEPSIA

Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia

(2011) Linnea Stridh et al.   Journal of Neuroinflammation

Perinatal Acidosis and Hypoxic-Ischemic Encephalopathy in Preterm Infants of 33 to 35 Weeks’ Gestation

(2011) Lina F. Chalak et al.   JOURNAL OF PEDIATRICS

Treatment advances in neonatal neuroprotection and neurointensive care

(2011) Michael V Johnston et al.   LANCET NEUROLOGY

Neonatal seizures in a rural Kenyan District Hospital: aetiology, Incidence and outcome of hospitalization

(2010) Michael Mwaniki et al.   BMC Medicine

Alterations in cortical GABAB receptors in neonatal rats exposed to hypoxic stress: role of glucose, oxygen, and epinephrine resuscitation

(2010) T. R. Anju et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Preterm birth results in alterations in neural connectivity at age 16 years

(2010) Katherine M. Mullen et al.   NEUROIMAGE

Release of Adenosine and ATP During Ischemia and Epilepsy

(2009) Nicholas Dale et al.   Current Neuropharmacology

Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model

(2009) Paven K. Aujla et al.   EPILEPSIA

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Increased Umbilical Cord Plasma Interleukin-1  Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

(2009) J. Liu et al.   JOURNAL OF TROPICAL PEDIATRICS

NAP prevents hippocampal oxidative damage in neonatal rats subjected to hypoxia-induced seizures

(2009) Samuel Greggio et al.   NEUROBIOLOGY OF DISEASE

Short- and long-term influences of hypoxia during early postnatal period of development on behavioral and hormonal responses in rats

(2009) Victor A. Mikhailenko et al.   NEUROSCIENCE LETTERS

Mast Cells Are Early Responders After Hypoxia-Ischemia in Immature Rat Brain

(2009) Yuxuan Jin et al.   STROKE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

RESEARCH ARTICLE: Myelin Abnormalities without Oligodendrocyte Loss in Periventricular Leukomalacia

(2008) Saraid S. Billiards et al.   BRAIN PATHOLOGY

Short hypoxia could attenuate the adverse effects of hyperhomocysteinemia on the developing rat brain by inducing neurogenesis

(2008) Sébastien A. Blaise et al.   EXPERIMENTAL NEUROLOGY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

(2007) Rozenn Mingam et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of neonatal asphyxia and hind limb immobilization on musculoskeletal tissues and S1 map organization: Implications for cerebral palsy

(2007) Jacques-Olivier Coq et al.   EXPERIMENTAL NEUROLOGY