Article
Biochemistry & Molecular Biology
Marco Ghibaudi, Alessia Amenta, Miriam Agosti, Marco Riva, Jean-Marie Graic, Francesco Bifari, Luca Bonfanti
Summary: Recently, a population of immature neurons generated prenatally, retaining immaturity for long periods and finally integrating in adult circuits has been described in the cerebral cortex. Comparative studies revealed differences in occurrence/rate of different forms of neurogenic plasticity across mammals, with gyrencephalic species having more immature neurons. To extend experimentation to large-brained mammals, including humans, it is important to detect cell markers of neurogenic plasticity in brain tissues obtained through different procedures. However, the variability in fixation methods and antibody specificity makes comparison difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Marco Ghibaudi, Luca Bonfanti
Summary: Undifferentiated neurons may exist in the neural networks of the adult mammalian brain, not only in small stem cell niches from embryonic germinal layers but also in various parenchymal brain regions. However, our understanding of these young neurons is not yet clear, and further mapping and research are needed.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Cui Li, Yu Zheng, Yufang Zheng, Zhiheng Xu
Summary: Mutations in the WDR60 gene have been linked to short-rib polydactyly syndromes, affecting embryonic development and the migration of newborn neurons during brain development. WDR60 plays a crucial role in controlling microtubule organization, with potential implications for understanding the pathogenesis of SRPS.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Elina Makinen, Sanna Lensu, Markus Honkanen, Paavo Laitinen, Jan Wikgren, Lauren G. Koch, Steven L. Britton, Heikki Kainulainen, Satu Pekkala, Miriam S. Nokia
Summary: The study revealed that low intrinsic aerobic fitness associated with obesity and poor metabolic health is linked with reduced hippocampal structural plasticity at a young age, indicating that brain inflammation may be a factor mediating the link between obesity and poor cognitive performance.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Li Zhang, Xiaowen Xu, Liya Ma, Xinxin Wang, Meifang Jin, Lili Li, Hong Ni
Summary: This study explores the effects of zinc water supplementation on autism-like behavior, seizure threshold, and neurogenesis in ASD model mice. The results show that zinc water supplementation for 6 weeks can prevent autism-like behavior, reduce susceptibility to seizures, and increase the proliferation of hippocampal progenitor cells in BTBR mice. However, it has less effect on mossy fiber sprouting and neural progenitor cell differentiation. The findings suggest that zinc water can reduce autism-like behavior in a partially inherited autism model mice by promoting hippocampal neural precursor cell proliferation and reversing hyperexcitability.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Hospitality, Leisure, Sport & Tourism
Ruben Fernandez-Rodriguez, Celia Alvarez-Bueno, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino, Arthur Eumann Mesas, Blanca Notario-Pacheco
Summary: This study examines the immediate effects of high-intensity exercise (HIE) on brain-derived neurotrophic factor (BDNF) levels in young adults. The results suggest that performing HIE may lead to an immediate increase in BDNF levels compared to non-exercise or light-intensity exercise.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2022)
Article
Clinical Neurology
Ozlem Tugce Cilingir-Kaya, Cynthia Moore, Charles Kenneth Meshul, Duygu Gursoy, Filiz Onat, Serap Sirvanci
Summary: The study found that newly born neurons are incorporated into the local hippocampal network in both GAERS and control Wistar rats, suggesting their involvement in the mechanism underlying absence seizures in GAERS.
TURKISH NEUROSURGERY
(2021)
Article
Neurosciences
Giuliana T. M. Cardoso, Walace Gomes-Leal, Edna C. S. Franco, Antonio Pereira Jr, Francinaldo L. L. Gomes, Ana Leda F. Brino, Silene M. A. Lima
Summary: Hippocampectomy does not lead to cognitive impairment and may induce compensatory neurogenesis in the remaining hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xianmixinuer Abulaiti, Aifang Wang, Han Zhang, Hang Su, Rui Gao, Jiayu Chen, Shaorong Gao, Lingsong Li
Summary: Abnormal mossy fiber connections in the hippocampus have been found in patients with schizophrenia, but the genetic basis and its contribution to the development of schizophrenia were unclear. This study demonstrated that a high-risk allele of SNP rs16864067 downregulated the SOX11 gene, leading to abnormal polarity in hippocampal neural progenitor cells derived from schizophrenia patients. A mouse model with SOX11 deficiency showed similar abnormal polarity and hippocampal neurogenesis defects, resulting in disrupted mossy fiber connections and schizophrenia-like behaviors. Activation of hippocampal neurogenesis during embryonic development partially alleviated these disruptions and improved schizophrenia-related behaviors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Young-Jin Kang, Sang -Hun Lee, Jeffery A. Boychuk, Corwin R. Butler, J. Anna Juras, Ryan A. Cloyd, Bret N. Smith
Summary: Post-traumatic epilepsy and behavioral comorbidities often occur after traumatic brain injury. The neurogenesis of dentate granule cells after injury may contribute to the synaptic reorganization in epilepsy, but the specific role of neurogenesis at different times relative to the injury is unknown. This study found that the birth date of dentate granule cells is related to increased feedback inhibition in the dentate gyrus, which may contribute to altered excitability after brain injury.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Gemma Huguet, Irene Puig-Parnau, Jose C. E. Serrano, Meritxell Martin-Gari, Maria Rodriguez-Palmero, Jose Antonio Moreno-Munoz, Joan Tibau, Elisabet Kadar
Summary: Childhood obesity, caused by a diet rich in sugars and fatty acids, can lead to cognitive impairment and reduced neuroplasticity. A study on young female pigs found that a diet enriched with Bifidobacterium breve and omega-3 fatty acids can enhance neuroplasticity in prepubertal female pigs on a high-fat diet.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Yu
Summary: This study investigates the antidepressant property of PEA and its potential therapeutic effects on depressive mood disorders. The results suggest that PEA can target hippocampal neuroplasticity, including increasing adult neurogenesis and synaptic plasticity, as well as reducing neuronal apoptosis, to remodel hippocampal circuitries. The PPAR & alpha; pathway may be involved in this process.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Georgios Alkis Zisiadis, Androniki Alevyzaki, Elene Nicola, Carlos F. D. Rodrigues, Klas Blomgren, Ahmed M. Osman
Summary: Cranial irradiation negatively affects hippocampal neurogenesis and cognition, and memantine has been proposed as an intervention to improve cognitive impairments after radiotherapy. However, the mechanisms by which memantine improves neurogenesis and cognition after irradiation remain unclear. This study found that memantine can enhance neuronal proliferation and dendritic development, but does not affect neurogenesis after irradiation. The enhanced dendritic complexity of young neurons may contribute to the observed improvement in cognition.
FRONTIERS IN ONCOLOGY
(2023)
Article
Plant Sciences
Ekaterina-Michaela Tomou, Lara Bieler, Tobias Spoettl, Sebastien Couillard-Despres, Helen Skaltsa, Corinna Urmann
Summary: In recent years, research has shown that Sideritis extracts can improve memory. However, their potential to promote the generation of new neurons through neural stem cell differentiation has not been explored. This study evaluates the neurogenic effects of different Sideritis infusions on neural stem and precursor cells, as well as their impact on cell viability. Metabolic fingerprints were also recorded using various analytical techniques. The results suggest that Sideritis infusions have potent neurogenic potential and may be useful in the treatment of neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Luca Bonfanti, Christine J. Charvet
Summary: Plasticity, especially neurogenesis, is a promising target for treating and preventing various diseases; different types of plasticity vary with age, brain region, and species; plasticity decreases with age, but comparisons between different forms of plasticity across species are still lacking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)