Cardiovascular Manifestations of COVID-19 Infection

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

SARS-CoV-2: a potential novel etiology of fulminant myocarditis

(2020) Chen Chen et al.   HERZ

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Viral load of SARS-CoV-2 in clinical samples

(2020) Yang Pan et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

(2020) Lan T. Phan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Covid-19 — Navigating the Uncharted

(2020) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

(2020) Lirong Zou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

The Cardiovascular Complications of Chimeric Antigen Receptor T Cell Therapy

(2020) Faizi A. Jamal et al.   Current Hematologic Malignancy Reports

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Defective Anti-oxidant System: An Aggravating Factor for COVID-19 Patients Outcome?

(2020) Eva N. Kassi et al.   ARCHIVES OF MEDICAL RESEARCH

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19 infection: the perspectives on immune responses

(2020) Yufang Shi et al.   CELL DEATH AND DIFFERENTIATION

Angiotensin Converting Enzyme 2: A Double-Edged Sword

(2020) Kaiming Wang et al.   CIRCULATION

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

(2020) Bo Li et al.   Clinical Research in Cardiology

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

(2020) Luka Nicin et al.   EUROPEAN HEART JOURNAL

Acute pulmonary embolism and COVID-19 pneumonia: a random association?

(2020) Gian Battista Danzi et al.   EUROPEAN HEART JOURNAL

Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin

(2020) Hongde Hu et al.   EUROPEAN HEART JOURNAL

First case of COVID-19 complicated with fulminant myocarditis: a case report and insights

(2020) Jia-Hui Zeng et al.   INFECTION

Care for Critically Ill Patients With COVID-19

(2020) Srinivas Murthy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic

(2020) Elissa Driggin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients

(2020) Jean‐François Llitjos et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical course and mortality risk of severe COVID-19

(2020) Paul Weiss et al.   LANCET

Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures

(2020) Rachael Pung et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Early dynamics of transmission and control of COVID-19: a mathematical modelling study

(2020) Adam J Kucharski et al.   LANCET INFECTIOUS DISEASES

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

(2020) Yan Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography

(2020) Franck Grillet et al.   RADIOLOGY

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Tao Guo et al.   JAMA Cardiology

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

(2020) Shaobo Shi et al.   JAMA Cardiology

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science

(2020) Paul C Evans et al.   CARDIOVASCULAR RESEARCH

Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

(2020) Jing Sun et al.   CELL

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis

(2020) Giuseppe Lippi et al.   CLINICA CHIMICA ACTA

ACE2 down-regulation may contribute to the increased thrombotic risk in COVID-19

(2020) Laura Lupi et al.   EUROPEAN HEART JOURNAL

Pulmonary embolism in COVID-19 patients: a French multicentre cohort study

(2020) Charles Fauvel et al.   EUROPEAN HEART JOURNAL

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Feng-Cai Zhu et al.   LANCET

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

(2020) Jingyun Yang et al.   NATURE

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

(2020) Vijendra Ramlall et al.   NATURE MEDICINE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Endothelial cells orchestrate COVID-19 coagulopathy

(2020) Jamie M O'Sullivan et al.   Lancet Haematology

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Single‐cell RNA sequencing analysis of SARS‐CoV‐2 entry receptors in human organoids

(2020) Rajasekaran Mahalingam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID-19

(2020) Sushil K. Jain et al.   FREE RADICAL BIOLOGY AND MEDICINE

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Enhanced NOX-2 derived oxidative stress in offspring of patients with early myocardial infarction

(2019) Lorenzo Loffredo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The stimulation of thrombosis by hypoxia

(2019) Neha Gupta et al.   THROMBOSIS RESEARCH

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study

(2017) Khaled O Alsaad et al.   HISTOPATHOLOGY

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Cross Talk Pathways Between Coagulation and Inflammation

(2016) Jonathan H. Foley et al.   CIRCULATION RESEARCH

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

(2016) Eu Suk Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases

(2015) O. S. Kornfeld et al.   CIRCULATION RESEARCH

Innate Immunity and the Failing Heart

(2015) Douglas L. Mann   CIRCULATION RESEARCH

ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity

(2015) Vaibhav B. Patel et al.   DIABETES

Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia

(2015) Yan Fei Qi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Platelets Are Not Just for Clots

(2015) James D. McFadyen et al.   TRANSFUSION MEDICINE REVIEWS

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II–Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling

(2014) Vaibhav B. Patel et al.   HYPERTENSION

From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

(2014) Sheila K. Patel et al.   Frontiers in Physiology

A decade after SARS: strategies for controlling emerging coronaviruses

(2013) Rachel L. Graham et al.   NATURE REVIEWS MICROBIOLOGY

Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Assessment of Endothelial Function

(2012) Andreas J. Flammer et al.   CIRCULATION

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction

(2010) JiuChang Zhong et al.   CIRCULATION

Circulating Rather Than Cardiac Angiotensin-(1-7) Stimulates Cardioprotection After Myocardial Infarction

(2010) Yong Wang et al.   Circulation-Heart Failure

Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2

(2010) JiuChang Zhong et al.   HYPERTENSION

Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction

(2009) Zamaneh Kassiri et al.   Circulation-Heart Failure

Elevated cardiac troponin is an independent risk factor for short- and long-term mortality in medical intensive care unit patients

(2009) Luciano Babuin et al.   CRITICAL CARE MEDICINE

SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

(2009) G. Y. Oudit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Myocarditis

(2009) Leslie T. Cooper   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress and left ventricular remodelling after myocardial infarction

(2008) M. Hori et al.   CARDIOVASCULAR RESEARCH

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL