The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID-19

Targeted 25-hydroxyvitamin D concentration measurements and vitamin D3 supplementation can have important patient and public health benefits

(2020) William B. Grant et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is linked with cardiovascular disease

(2020) Rajesh Parsanathan et al.   HYPERTENSION RESEARCH

Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept

(2020) Pierre-Marie Duret et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients

(2020) Virginia M. Lindley et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

Is glucose-6-phosphate dehydrogenase enzyme deficiency a factor in Coronavirus-19 (COVID-19) infections and deaths?

(2020) Duygu Aydemir et al.   Pathogens and Global Health

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020

(2020) Shikha Garg et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Hyperglycemia at Hospital Admission Is Associated With Severity of the Prognosis in Patients Hospitalized for COVID-19: The Pisa COVID-19 Study

(2020) Alberto Coppelli et al.   DIABETES CARE

Computed Tomography Highlights Increased Visceral Adiposity Associated With Critical Illness in COVID-19

(2020) Sofia Battisti et al.   DIABETES CARE

Diabetes and COVID-19: Moving From News to Knowledge and a Glucose Hypothesis

(2020) Matthew C. Riddle   DIABETES CARE

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

(2020) Helmut Sies et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytokine storm and leukocyte changes in mild versus severe SARS‐CoV‐2 infection: Review of 3939 COVID‐19 patients in China and emerging pathogenesis and therapy concepts

(2020) Jin Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating levels of IL‐2, IL‐4, TNF‐α, IFN‐γ, and C‐reactive protein are not associated with severity of COVID‐19 symptoms

(2020) Wen Luo et al.   JOURNAL OF MEDICAL VIROLOGY

Vitamin D insufficiency as a potential culprit in critical COVID‐19 patients

(2020) Ruhul Munshi et al.   JOURNAL OF MEDICAL VIROLOGY

Vitamin D for COVID-19: a case to answer?

(2020) Adrian R Martineau et al.   Lancet Diabetes & Endocrinology

The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectional pilot study in Germany

(2020) Antonia Petersen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High glucose−induced ubiquitination of G6PD leads to the injury of podocytes

(2019) Meng Wang et al.   FASEB JOURNAL

Cumulative Psychosocial Stress and Ideal Cardiovascular Health in Older Women: Data by Race/Ethnicity

(2019) Melissa S. Burroughs-Peña et al.   CIRCULATION

Glutathione-dependent enzyme activities of peripheral blood mononuclear cells decrease during the winter season compared with the summer in normal-weight and severely obese adolescents

(2019) David Montero et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Plasma cysteine/cystine and glutathione/glutathione disulfide redox potentials in HIV and COPD patients

(2019) Walter H. Watson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione depletion, lipid peroxidation, and the antecedents of ferroptosis: What about cellular calcium ?

(2019) Alfonso Pompella et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases

(2019) Rajesh Parsanathan et al.   Metabolic Syndrome and Related Disorders

Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

(2019) Rajesh Parsanathan et al.   Scientific Reports

Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial

(2019) Arash Shirvani et al.   Scientific Reports

Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity

(2019) Da Hye Kwon et al.   Antioxidants

l-Cysteine in vitro can restore cellular glutathione and inhibits the expression of cell adhesion molecules in G6PD-deficient monocytes

(2018) Rajesh Parsanathan et al.   AMINO ACIDS

Impaired glutathione-related antioxidant defenses in the arterial tissue of diabetic patients

(2018) Domenico Lapenna et al.   FREE RADICAL BIOLOGY AND MEDICINE

The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models

(2018) Markus H. Hoffmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alpha-1 antitrypsin deficiency: outstanding questions and future directions

(2018) María Torres-Durán et al.   Orphanet Journal of Rare Diseases

Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age

(2018) Alfonso M. Lechuga-Sancho et al.   PLoS One

Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages

(2018) Sue-jie Koo et al.   Frontiers in Immunology

Glutathione stimulates vitamin D regulatory genes, and lowers inflammation and increases 25-hydroxy-vitamin D levels in blood: A novel approach to treat 25-hydroxy-vitamin D-deficiency

(2018) Sushil K. Jain et al.   ANTIOXIDANTS & REDOX SIGNALING

Vitamin D and Influenza—Prevention or Therapy?

(2018) Beata M. Gruber–Bzura   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D

(2018) Mahdieh Abbasalizad Farhangi et al.   PLoS One

Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice

(2018) Rajesh Parsanathan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine

(2018) Rajesh Parsanathan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency

(2017) Nina Dickerhof et al.   FREE RADICAL BIOLOGY AND MEDICINE

Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren

(2017) Jennifer M Sacheck et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention

(2017) Michael F. Holick   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Redox signaling: An evolution from free radicals to aging

(2016) Henry Jay Forman   FREE RADICAL BIOLOGY AND MEDICINE

L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats

(2016) Sushil K. Jain et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Role of Chronic Psychosocial Stress in Explaining Racial Differences in Stress Reactivity and Pain Sensitivity

(2016) Jennifer L. Gordon et al.   PSYCHOSOMATIC MEDICINE

Elevated peripheral blood mononuclear cell-derived superoxide production in healthy young black men

(2015) Shekhar H. Deo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance

(2015) Hsiang-yu Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

High fat diet-Induced obesity alters vitamin D metabolizing enzyme expression in mice

(2015) Jeong Min Park et al.   BIOFACTORS

Conflicting reports on vitamin D supplementation: Evidence from randomized controlled trials

(2015) Richard D. Lewis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glutathionyl systems and metabolic dysfunction in obesity

(2015) Matthew J. Picklo et al.   NUTRITION REVIEWS

G6PD deficiency: a polymorphism balanced by heterozygote advantage against malaria

(2015) Lucio Luzzatto   Lancet Haematology

Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults

(2014) Jessica A. Alvarez et al.   CLINICAL ENDOCRINOLOGY

Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients

(2014) S K Jain et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

(2014) Wuelton M Monteiro et al.   MALARIA JOURNAL

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

(2013) Sushil K. Jain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin D for Health: A Global Perspective

(2013) Arash Hossein-nezhad et al.   MAYO CLINIC PROCEEDINGS

Association of racial disparities in the prevalence of insulin resistance with racial disparities in vitamin D levels: National Health and Nutrition Examination Survey (2001-2006)

(2013) Stephen K. Williams et al.   NUTRITION RESEARCH

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

(2013) Arash Hossein-nezhad et al.   PLoS One

Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema

(2013) Mardi A. Crane-Godreau et al.   Frontiers in Physiology

Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men

(2012) Elizabeth Garrett-Mayer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease

(2012) Peter A. Hecker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

(2012) Kai Soo Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin D Status is Linked to Biomarkers of Oxidative Stress, Inflammation, and Endothelial Activation in Obese Children

(2012) Pilar Codoñer-Franch et al.   JOURNAL OF PEDIATRICS

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vitamin D Status, Adiposity, and Lipids in Black American and Caucasian Children

(2011) Kumaravel Rajakumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D and the anti-viral state

(2011) Jeremy A. Beard et al.   JOURNAL OF CLINICAL VIROLOGY

Race Differences in the Association of Oxidative Stress With Insulin Sensitivity in African- and European-American Women

(2011) Gordon Fisher et al.   Obesity

Vitamin D Receptor Activator Reduces Oxidative Stress in Hemodialysis Patients With Secondary Hyperparathyroidism

(2011) Motoko Tanaka et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Aldosterone and inflammation

(2011) Kimberly C Gilbert et al.   Current Opinion in Endocrinology Diabetes and Obesity

Effects of Supplemental Vitamin D and Calcium on Oxidative DNA Damage Marker in Normal Colorectal Mucosa: A Randomized Clinical Trial

(2010) V. Fedirko et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

(2010) R. V. Sekhar et al.   DIABETES CARE

1α,25 Dihydroxyvitamin D3: Therapeutic and Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan-Induced Diabetes in Rats

(2009) Khaled HAMDEN et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Aldosterone: A forgotten mediator of the relationship between psychological stress and heart disease

(2009) Laura D. Kubzansky et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Glucose‐6‐Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection

(2008) Yi‐Hsuan Wu et al.   JOURNAL OF INFECTIOUS DISEASES

Glucose-6-phosphate dehydrogenase deficiency

(2008) MD Cappellini et al.   LANCET

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE