The Genomics of Myelodysplastic Syndromes: Origins of Disease Evolution, Biological Pathways, and Prognostic Implications
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Title
The Genomics of Myelodysplastic Syndromes: Origins of Disease Evolution, Biological Pathways, and Prognostic Implications
Authors
Keywords
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Journal
Cells
Volume 9, Issue 11, Pages 2512
Publisher
MDPI AG
Online
2020-11-20
DOI
10.3390/cells9112512
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Note: Only part of the references are listed.- Results of a Clinical Trial of H3B-8800, a Splicing Modulator, in Patients with Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML)
- (2020) David P. Steensma et al. BLOOD
- SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications
- (2020) Shalini Singh et al. LEUKEMIA
- Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
- (2020) Pierre Fenaux et al. NEW ENGLAND JOURNAL OF MEDICINE
- The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
- (2020) Ana Rio-Machin et al. Nature Communications
- Targeting isocitrate dehydrogenase mutations (IDH) in AML: wielding the double-edged sword of differentiation
- (2020) Justin S. Becker et al. CURRENT CANCER DRUG TARGETS
- Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
- (2020) Elsa Bernard et al. NATURE MEDICINE
- Case Report: Late Onset of Myelodysplastic Syndrome From Donor Progenitor Cells After Allogeneic Stem Cell Transplantation. Which Lessons Can We Draw From the Reported Case?
- (2020) Mirko Farina et al. Frontiers in Oncology
- TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups
- (2019) Detlef Haase et al. LEUKEMIA
- BCOR and BCORL1 mutations in myelodysplastic syndromes (MDS): clonal architecture and impact on outcomes
- (2019) Nour Abuhadra et al. LEUKEMIA & LYMPHOMA
- Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes
- (2019) Matilde Y. Follo et al. LEUKEMIA
- Genetic predisposition to MDS: clinical features and clonal evolution
- (2019) Alyssa L. Kennedy et al. BLOOD
- Genetics of MDS
- (2019) Seishi Ogawa BLOOD
- Hippo Kinase Loss Contributes to Del(20q) Hematologic Malignancies through Chronic Innate Immune Activation
- (2019) Samuel A. Stoner et al. BLOOD
- Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
- (2019) Jia Yi Fong et al. CANCER CELL
- Genomics of therapy-related myeloid neoplasms
- (2019) Teodora Kuzmanovic et al. HAEMATOLOGICA
- Synergistic effects of PRIMA-1Met (APR-246) and Azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia
- (2019) Nabih Maslah et al. HAEMATOLOGICA
- Leukemia evolving from paroxysmal nocturnal hemoglobinuria
- (2019) Hassan Awada et al. LEUKEMIA
- Expression analysis of genes located within the common deleted region of del(20q) in patients with myelodysplastic syndromes
- (2019) Masayuki Shiseki et al. LEUKEMIA RESEARCH
- Germline DDX41 mutations define a significant entity within adult MDS/AML patients
- (2019) Marie Sébert et al. BLOOD
- Large granular lymphocytic leukemia coexists with myeloid clones and myelodysplastic syndrome
- (2019) Jibran Durrani et al. LEUKEMIA
- Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes
- (2019) Yasunobu Nagata et al. Nature Communications
- Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations
- (2018) Andrea Pellagatti et al. BLOOD
- The enigma of monosomy 7
- (2018) Toshiya Inaba et al. BLOOD
- SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells
- (2018) Yang Liang et al. LEUKEMIA
- Consequences of mutant TET2 on clonality and subclonal hierarchy
- (2018) Cassandra M. Hirsch et al. LEUKEMIA
- ASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics
- (2018) Katerina Kakosaiou et al. LEUKEMIA & LYMPHOMA
- Autoimmune manifestations associated with myelodysplastic syndromes
- (2018) Eric Grignano et al. ANNALS OF HEMATOLOGY
- Role of p53 Gene in Breast Cancer: Focus on Mutation Spectrum and Therapeutic strategies
- (2018) Raman Preet Kaur et al. CURRENT PHARMACEUTICAL DESIGN
- European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation
- (2018) Nicole Engel et al. LEUKEMIA
- Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes
- (2018) Yasunobu Nagata et al. BLOOD
- Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation
- (2018) Mareike Frick et al. JOURNAL OF CLINICAL ONCOLOGY
- Germline ETV6 mutations and predisposition to hematological malignancies
- (2017) Simone Feurstein et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
- (2017) Bon Ham Yip et al. JOURNAL OF CLINICAL INVESTIGATION
- Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma
- (2017) Christopher J. Gibson et al. JOURNAL OF CLINICAL ONCOLOGY
- Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
- (2017) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
- (2017) Ting Han et al. SCIENCE
- Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions
- (2017) Peter Valent et al. Oncotarget
- The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
- (2016) D. A. Arber et al. BLOOD
- The Impact of Somatic and Germline Mutations in Myelodysplastic Syndromes and Related Disorders
- (2016) Rafael Bejar et al. Journal of the National Comprehensive Cancer Network
- Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes
- (2016) H Dolatshad et al. LEUKEMIA
- Dynamics of clonal evolution in myelodysplastic syndromes
- (2016) Hideki Makishima et al. NATURE GENETICS
- Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome
- (2016) Feng Xu et al. Oncotarget
- Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing
- (2015) Cecilia C.S. Yeung et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
- (2015) L. Malcovati et al. BLOOD
- MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance
- (2015) B. Kwok et al. BLOOD
- Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
- (2015) D. P. Steensma et al. BLOOD
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- (2015) Chantana Polprasert et al. CANCER CELL
- Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes
- (2015) D A Sallman et al. LEUKEMIA
- CEBPA methylation and mutation in myelodysplastic syndrome
- (2015) Xiang-mei Wen et al. MEDICAL ONCOLOGY
- Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
- (2015) Michael Y Zhang et al. NATURE GENETICS
- Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- Deregulation of Genes Related to Iron and Mitochondrial Metabolism in Refractory Anemia with Ring Sideroblasts
- (2015) Mónica del Rey et al. PLoS One
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- (2014) A. Stoddart et al. BLOOD
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- (2014) R. Bejar et al. BLOOD
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- (2014) S. Thota et al. BLOOD
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- (2014) Andrew C. Dietz et al. BRITISH JOURNAL OF HAEMATOLOGY
- Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS
- (2014) Rebekka K. Schneider et al. CANCER CELL
- MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
- (2014) Chong Chen et al. CANCER CELL
- Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia
- (2014) Justin J.-L. Wong et al. CANCER SCIENCE
- Clinical and genetic predictors of prognosis in myelodysplastic syndromes
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- Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations
- (2014) J.-B. Micol et al. HAEMATOLOGICA
- Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation
- (2014) Rafael Bejar et al. JOURNAL OF CLINICAL ONCOLOGY
- Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron
- (2014) V Visconte et al. LEUKEMIA
- Age-related mutations associated with clonal hematopoietic expansion and malignancies
- (2014) Mingchao Xie et al. NATURE MEDICINE
- Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
- (2014) Giulio Genovese et al. NEW ENGLAND JOURNAL OF MEDICINE
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
- (2014) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
- (2014) Goro Sashida et al. Nature Communications
- Deletion 5q MDS: Molecular and therapeutic implications
- (2013) Rami S. Komrokji et al. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes
- (2013) Y. Harada et al. BLOOD
- BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders
- (2013) F. Damm et al. BLOOD
- Clinical and biological implications of driver mutations in myelodysplastic syndromes
- (2013) E. Papaemmanuil et al. BLOOD
- Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact
- (2013) Ulrike Bacher et al. BRITISH JOURNAL OF HAEMATOLOGY
- Refractoriness of Intestinal Behçet's Disease with Myelodysplastic Syndrome Involving Trisomy 8 to Medical Therapies - Our Case Experience and Review of the Literature
- (2013) Takahiko Toyonaga et al. DIGESTION
- Sweet syndrome: Clinical presentation, associations, and response to treatment in 77 patients
- (2013) Nicole M. Rochet et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
- (2013) T Haferlach et al. LEUKEMIA
- Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
- (2013) Ayana Kon et al. NATURE GENETICS
- Inactivating CUX1 mutations promote tumorigenesis
- (2013) Chi C Wong et al. NATURE GENETICS
- A Meta-Analysis of the Relationship between Cigarette Smoking and Incidence of Myelodysplastic Syndromes
- (2013) Hongyan Tong et al. PLoS One
- Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
- (2012) F. Thol et al. BLOOD
- Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
- (2012) H. Makishima et al. BLOOD
- Revised International Prognostic Scoring System for Myelodysplastic Syndromes
- (2012) P. L. Greenberg et al. BLOOD
- Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes
- (2012) Sílvia Saumell et al. BRITISH JOURNAL OF HAEMATOLOGY
- Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
- (2012) Jeffrey A. Magee et al. CANCER CELL
- The Origin and Evolution of Mutations in Acute Myeloid Leukemia
- (2012) John S. Welch et al. CELL
- Incidence of 17p deletions andTP53mutation in myelodysplastic syndrome and acute myeloid leukemia with 5q deletion
- (2012) Amel Sebaa et al. GENES CHROMOSOMES & CANCER
- Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes
- (2012) Rafael Bejar et al. JOURNAL OF CLINICAL ONCOLOGY
- New Comprehensive Cytogenetic Scoring System for Primary Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia After MDS Derived From an International Database Merge
- (2012) Julie Schanz et al. JOURNAL OF CLINICAL ONCOLOGY
- Donor Cell–Derived Leukemias/Myelodysplastic Neoplasms in Allogeneic Hematopoietic Stem Cell Transplant Recipients
- (2011) Endi Wang et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications
- (2011) H.-A. Hou et al. BLOOD
- Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome
- (2011) M. S. Kumar et al. BLOOD
- Cytogenetic abnormalities in myelodysplastic syndrome: an overview
- (2011) Nikesh Kawankar et al. Hematology
- Prognostic Significance of ASXL1 Mutations in Patients With Myelodysplastic Syndromes
- (2011) Felicitas Thol et al. JOURNAL OF CLINICAL ONCOLOGY
- Coalesced Multicentric Analysis of 2,351 Patients With Myelodysplastic Syndromes Indicates an Underestimation of Poor-Risk Cytogenetics of Myelodysplastic Syndromes in the International Prognostic Scoring System
- (2011) Julie Schanz et al. JOURNAL OF CLINICAL ONCOLOGY
- Unraveling the Molecular Pathophysiology of Myelodysplastic Syndromes
- (2011) Rafael Bejar et al. JOURNAL OF CLINICAL ONCOLOGY
- TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression
- (2011) Martin Jädersten et al. JOURNAL OF CLINICAL ONCOLOGY
- Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
- (2011) M J Walter et al. LEUKEMIA
- Characteristics and outcome of myelodysplastic syndromes (MDS) with isolated 20q deletion: A report on 62 cases
- (2011) Thorsten Braun et al. LEUKEMIA RESEARCH
- Frequent pathway mutations of splicing machinery in myelodysplasia
- (2011) Kenichi Yoshida et al. NATURE
- GATA2 mutations lead to MDS and AML
- (2011) R. Katherine Hyde et al. NATURE GENETICS
- Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
- (2011) Timothy A Graubert et al. NATURE GENETICS
- Clinical Effect of Point Mutations in Myelodysplastic Syndromes
- (2011) Rafael Bejar et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular Dissection of the 5q Deletion in Myelodysplastic Syndrome
- (2011) Benjamin L. Ebert SEMINARS IN ONCOLOGY
- Genetic deletions in AML and MDS
- (2010) Benjamin L. Ebert BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice
- (2010) T. H.- P. Chen et al. BLOOD
- Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
- (2010) A. E. Smith et al. BLOOD
- Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
- (2010) Letetia Jones et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
- (2010) J Boultwood et al. LEUKEMIA
- Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells
- (2010) A Pellagatti et al. LEUKEMIA
- Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
- (2010) Myunggon Ko et al. NATURE
- Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
- (2010) Marc H. G. P. Raaijmakers et al. NATURE
- Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
- (2010) Gorica Nikoloski et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
- (2009) O. Kosmider et al. BLOOD
- Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation
- (2009) N. Kroger et al. HAEMATOLOGICA
- Myelodysplastic Syndromes
- (2009) Ayalew Tefferi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Myelodysplastic syndromes
- (2008) S. D. Nimer BLOOD
- Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse
- (2008) P. Sportoletti et al. BLOOD
- AML1 mutations induced MDS and MDS/AML in a mouse BMT model
- (2008) N. Watanabe-Okochi et al. BLOOD
- Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes
- (2008) Andrea Pellagatti et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Epigenetic Origin of Aneuploidy
- (2008) Luis Herrera et al. CURRENT GENOMICS
- Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
- (2008) Benjamin L. Ebert et al. NATURE
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