The Nuclear Pore Complex and mRNA Export in Cancer

Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials

(2020) Maria Gavriatopoulou et al.   LEUKEMIA

Selinexor: a first-in-class SINE compound for treatment of relapsed refractory multiple myeloma

(2020) Shambavi Richard et al.   Future Oncology

The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts

(2020) Biljana Culjkovic-Kraljacic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway

(2020) Vasilisa Aksenova et al.   Nature Communications

The Structure of the Nuclear Pore Complex (An Update)

(2019) Daniel H. Lin et al.   Annual Review of Biochemistry

Structure and Assembly of the Nuclear Pore Complex

(2019) Bernhard Hampoelz et al.   Annual Review of Biophysics

Nuclear eIF4E Stimulates 3′-End Cleavage of Target RNAs

(2019) Margaret Rose Davis et al.   Cell Reports

Altered nuclear export signal recognition as a driver of oncogenesis

(2019) Justin Taylor et al.   Cancer Discovery

Oncogenic potential of nucleoporins in non-hematological cancers: recent update beyond chromosome translocation and gene fusion

(2019) Adhiraj Roy et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Surface Properties Determining Passage Rates of Proteins through Nuclear Pores

(2018) Steffen Frey et al.   CELL

Tpr regulates the total number of nuclear pore complexes per cell nucleus

(2018) Asako McCloskey et al.   GENES & DEVELOPMENT

Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease

(2018) Ramona Jühlen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

(2018) Karen A. Urtishak et al.   ONCOGENE

The Impact of Post-transcriptional Control: Better Living Through RNA Regulons

(2018) Biljana Culjkovic-Kraljacic et al.   Frontiers in Genetics

Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA/IVB human papillomavirus-associated oropharyngeal squamous cell cancer

(2017) Lara A. Dunn et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Alternative splicing as a regulator of development and tissue identity

(2017) Francisco E. Baralle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases

(2017) Hong Joo Kim et al.   NEURON

ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo

(2017) Min Shi et al.   NUCLEIC ACIDS RESEARCH

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery

(2017) Laurent Volpon et al.   RNA

The functional versatility of the nuclear pore complex proteins

(2017) Mohammed Hezwani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The roles of the nuclear pore complex in cellular dysfunction, aging and disease

(2017) Stephen Sakuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity

(2017) Hiba Ahmad Zahreddine et al.   eLife

A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia

(2016) N. A. Amin et al.   CLINICAL CANCER RESEARCH

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

(2016) Michaela Müller-McNicoll et al.   GENES & DEVELOPMENT

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

The Structure Inventory of the Nuclear Pore Complex

(2016) Thomas U. Schwartz   JOURNAL OF MOLECULAR BIOLOGY

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

(2016) Laurent Volpon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of the symmetric core of the nuclear pore

(2016) D. H. Lin et al.   SCIENCE

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

(2016) J. Kosinski et al.   SCIENCE

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis

(2015) F. Pettersson et al.   CANCER RESEARCH

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E

(2014) S. Assouline et al.   HAEMATOLOGICA

CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

(2014) N. Saito et al.   MOLECULAR CANCER THERAPEUTICS

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Randomized controlled trial of Inquiry-Based Stress Reduction (IBSR) technique forBRCA1/2mutation carriers

(2014) Carla Landau et al.   PSYCHO-ONCOLOGY

Nucleoporins and nucleocytoplasmic transport in hematologic malignancies

(2014) Akiko Takeda et al.   SEMINARS IN CANCER BIOLOGY

Post-transcriptional RNA regulons affecting cell cycle and proliferation

(2014) Jeff G. Blackinton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GANP enhances the efficiency of mRNA nuclear export in mammalian cells

(2014) Vihandha O. Wickramasinghe et al.   Nucleus

Regulation of mRNA Trafficking by Nuclear Pore Complexes

(2014) Amandine Bonnet et al.   Genes

Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate

(2013) Laurent Volpon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

(2013) K. Kojima et al.   BLOOD

Mammalian 5′-Capped MicroRNA Precursors that Generate a Single MicroRNA

(2013) Mingyi Xie et al.   CELL

The Oncogene eIF4E: Using Biochemical Insights to Target Cancer

(2013) Martin Carroll et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

(2013) Y-T Tai et al.   LEUKEMIA

Human Inositol Polyphosphate Multikinase Regulates Transcript-Selective Nuclear mRNA Export to Preserve Genome Integrity

(2013) Vihandha O. Wickramasinghe et al.   MOLECULAR CELL

Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport

(2013) Franziska Bollmann et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

(2013) Qingxiang Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aiding and abetting cancer: mRNA export and the nuclear pore

(2013) Biljana Culjkovic-Kraljacic et al.   TRENDS IN CELL BIOLOGY

Postage for the messenger: designating routes for nuclear mRNA export

(2013) Barbara J. Natalizio et al.   TRENDS IN CELL BIOLOGY

Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling

(2012) Sean D. Speese et al.   CELL

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

(2012) K. Yap et al.   GENES & DEVELOPMENT

ALY as a potential contributor to metastasis in human oral squamous cell carcinoma

(2012) Yasuhiro Saito et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Localization of Nucleoporin Tpr to the Nuclear Pore Complex Is Essential for Tpr Mediated Regulation of the Export of Unspliced RNA

(2012) Kalpana Rajanala et al.   PLoS One

TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

(2012) Nicolas Viphakone et al.   Nature Communications

The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation

(2012) Biljana Culjkovic-Kraljacic et al.   Cell Reports

Nuclear export of proteins and drug resistance in cancer

(2011) Joel G. Turner et al.   BIOCHEMICAL PHARMACOLOGY

mRNA export and the TREX complex

(2011) Jun Katahira   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

(2011) María S Domínguez-Sánchez et al.   BMC CANCER

Nucleoporins: Leaving the nuclear pore complex for a successful mitosis

(2011) Guillaume Chatel et al.   CELLULAR SIGNALLING

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer

(2011) F. Pettersson et al.   CLINICAL CANCER RESEARCH

A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer

(2011) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Linking gene regulation to mRNA production and export

(2011) Susana Rodríguez-Navarro et al.   CURRENT OPINION IN CELL BIOLOGY

Ran-dependent nuclear export mediators: a structural perspective

(2011) Thomas Güttler et al.   EMBO JOURNAL

The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1

(2011) K. N. Noble et al.   GENES & DEVELOPMENT

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability

(2011) Masakazu Hamada et al.   JOURNAL OF CELL BIOLOGY

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

(2011) B C Kraljacic et al.   LEUKEMIA

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

(2011) Ben Montpetit et al.   NATURE

Nuclear import by karyopherin-βs: Recognition and inhibition

(2010) Yuh Min Chook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

(2010) Masako Koyama et al.   EMBO JOURNAL

ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex

(2010) K. Dufu et al.   GENES & DEVELOPMENT

Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange

(2010) Nobukazu Okamoto et al.   GENES TO CELLS

Gene Regulation by Nucleoporins and Links to Cancer

(2010) Alwin Köhler et al.   MOLECULAR CELL

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

(2010) Y. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

mRNA Export from Mammalian Cell Nuclei Is Dependent on GANP

(2009) Vihandha O. Wickramasinghe et al.   CURRENT BIOLOGY

Cargo surface hydrophobicity is sufficient to overcome the nuclear pore complex selectivity barrier

(2009) Bracha Naim et al.   EMBO JOURNAL

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

(2009) Ivan Topisirovic et al.   EMBO JOURNAL

The nuclear pore component Nup358 promotes transportin-dependent nuclear import

(2009) S. Hutten et al.   JOURNAL OF CELL SCIENCE

Oxidative Stress Inhibits Nuclear Protein Export by Multiple Mechanisms That Target FG Nucleoporins and Crm1

(2009) Noah Crampton et al.   MOLECULAR BIOLOGY OF THE CELL

Global signatures of protein and mRNA expression levels

(2009) Raquel de Sousa Abreu et al.   Molecular BioSystems

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner

(2009) Holger von Moeller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for assembly and disassembly of the CRM1 nuclear export complex

(2009) Xiuhua Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EXPRESSION OF CRM1 IN HUMAN GLIOMAS AND ITS SIGNIFICANCE IN P27 EXPRESSION AND CLINICAL PROGNOSIS

(2009) Aiguo Shen et al.   NEUROSURGERY

Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP

(2009) T. Monecke et al.   SCIENCE

Nuclear pore proteins and cancer

(2009) Songli Xu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

(2009) Biljana Culjkovic et al.   Journal of Oncology

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death

(2008) Xianqin Zhang et al.   CELL

The mRNA Export Factor Gle1 and Inositol Hexakisphosphate Regulate Distinct Stages of Translation

(2008) Timothy A. Bolger et al.   CELL

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

(2008) Meelad M. Dawlaty et al.   CELL

A Phase 2 Clinical Trial of Deforolimus (AP23573, MK-8669), a Novel Mammalian Target of Rapamycin Inhibitor, in Patients with Relapsed or Refractory Hematologic Malignancies

(2008) D. A. Rizzieri et al.   CLINICAL CANCER RESEARCH

Nucleoporin Levels Regulate Cell Cycle Progression and Phase-Specific Gene Expression

(2008) Papia Chakraborty et al.   DEVELOPMENTAL CELL

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER

The eIF4E RNA regulon promotes the Akt signaling pathway

(2008) Biljana Culjkovic et al.   JOURNAL OF CELL BIOLOGY

The Nup358-RanGAP Complex Is Required for Efficient Importin α/β-dependent Nuclear Import

(2008) Saskia Hutten et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease

(2008) Heidi O Nousiainen et al.   NATURE GENETICS

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA