Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells

ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

(2016) Bret R. Adams et al.   Aging-US

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

(2013) Bryan W. Day et al.   CANCER CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Smg1 haploinsufficiency predisposes to tumor formation and inflammation

(2013) Tara L. Roberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential of the Synthetic Lethality Principle

(2013) S. M. B. Nijman et al.   SCIENCE

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells

(2012) Y. C. Lim et al.   MOLECULAR CANCER THERAPEUTICS

Standards of care for treatment of recurrent glioblastoma—are we there yet?

(2012) Michael Weller et al.   NEURO-ONCOLOGY

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

A Novel Role for hSMG-1 in Stress Granule Formation

(2011) J. A. L. Brown et al.   MOLECULAR AND CELLULAR BIOLOGY

ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1

(2011) Bryan W. Day et al.   NEURO-ONCOLOGY

Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells

(2011) S. C. Short et al.   NEURO-ONCOLOGY

ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells

(2011) Bianca M. Sirbu et al.   PLoS One

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

(2011) A. G. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

Accumulation of CD133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation

(2010) Kaoru Tamura et al.   JOURNAL OF NEUROSURGERY

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants

(2010) Bret R. Adams et al.   PLoS One

ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot

(2010) Jiying Sun et al.   PLoS One

Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks

(2010) Elisia D. Tichy et al.   STEM CELLS AND DEVELOPMENT

DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine

(2009) Jarah A. Meador et al.   CARCINOGENESIS

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression

(2009) L Carlessi et al.   CELL DEATH AND DIFFERENTIATION

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

(2009) Stephanie L. Lomonaco et al.   INTERNATIONAL JOURNAL OF CANCER

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular responses to DNA double-strand breaks after low-dose γ-irradiation

(2009) Aroumougame Asaithamby et al.   NUCLEIC ACIDS RESEARCH

Homologous recombination in DNA repair and DNA damage tolerance

(2008) Xuan Li et al.   CELL RESEARCH

The Yku70–Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

(2008) Michela Clerici et al.   EMBO REPORTS

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GLIOMA EXTENT OF RESECTION AND ITS IMPACT ON PATIENT OUTCOME

(2008) Nader Sanai et al.   NEUROSURGERY