Artificial Intelligence for Histology-Based Detection of Microsatellite Instability and Prediction of Response to Immunotherapy in Colorectal Cancer

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Artificial intelligence as the next step towards precision pathology

(2020) B. Acs et al.   JOURNAL OF INTERNAL MEDICINE

Molecular Pathology of Lynch Syndrome

(2020) G Cerretelli et al.   JOURNAL OF PATHOLOGY

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

(2020) Ole-Johan Skrede et al.   LANCET

ImmuCellAI: A Unique Method for Comprehensive T‐Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy

(2020) Ya‐Ru Miao et al.   Advanced Science

Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer

(2020) Emilie Picard et al.   Frontiers in Immunology

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

(2020) Myriam Chalabi et al.   NATURE MEDICINE

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC

(2020) Xuanwen Bao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Clinical-grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

(2020) Amelie Echle et al.   GASTROENTEROLOGY

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

(2020) Korsuk Sirinukunwattana et al.   GUT

A deep learning model to predict RNA-Seq expression of tumours from whole slide images

(2020) Benoît Schmauch et al.   Nature Communications

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

(2019) Kellie N. Smith et al.   Journal for ImmunoTherapy of Cancer

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study

(2019) Jakob Nikolas Kather et al.   PLOS MEDICINE

Evaluating reproducibility of AI algorithms in digital pathology with DAPPER

(2019) Andrea Bizzego et al.   PLoS Computational Biology

Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors

(2019) M D Hellmann et al.   ANNALS OF ONCOLOGY

Predicting Response to Cancer Immunotherapy using Non-invasive Radiomic Biomarkers

(2019) S Trebeschi et al.   ANNALS OF ONCOLOGY

Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer

(2019) M Wiesweg et al.   ANNALS OF ONCOLOGY

Computed Tomography-Based Radiomic Features Could Potentially Predict Microsatellite Instability Status in Stage II Colorectal Cancer: A Preliminary Study

(2019) Shuxuan Fan et al.   ACADEMIC RADIOLOGY

Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer

(2019) A B Schrock et al.   ANNALS OF ONCOLOGY

INTRATUMORAL ADAPTIVE IMMUNOSUPPRESSION AND TYPE 17 IMMUNITY IN MISMATCH REPAIR PROFICIENT COLORECTAL TUMORS

(2019) Nicolas J Llosa et al.   CLINICAL CANCER RESEARCH

Using machine learning algorithms to predict response and toxicity to immune checkpoint inhibitors (ICIs) in melanoma patients.

(2019) Paul Johannet et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

(2019) Jordi Rodon et al.   NATURE MEDICINE

Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

(2019) Rajarsi Mandal et al.   SCIENCE

Analysis of the transcriptomic features of microsatellite instability subtype colon cancer

(2019) Haiwei Wang et al.   BMC CANCER

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

(2019) Jakob Nikolas Kather et al.   NATURE MEDICINE

Radiomics-based prediction of microsatellite instability in colorectal cancer at initial computed tomography evaluation

(2019) Jennifer S. Golia Pernicka et al.   Abdominal Radiology

Immune Activation in Mismatch Repair Deficient Carcinogenesis: More Than Just Mutational Rate

(2019) Jason A. Willis et al.   CLINICAL CANCER RESEARCH

Combination of TMB and CNA stratifies prognostic and predictive responses to immunotherapy across metastatic cancer

(2019) Li Liu et al.   CLINICAL CANCER RESEARCH

Artificial intelligence in digital pathology — new tools for diagnosis and precision oncology

(2019) Kaustav Bera et al.   Nature Reviews Clinical Oncology

The Crohn's-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and Potentially Therapeutic Relevance in Colorectal Cancer

(2019) Asaf Maoz et al.   Frontiers in Immunology

Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164

(2019) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors

(2019) Satya Das et al.   Journal for ImmunoTherapy of Cancer

Radiomics Analysis of Iodine-Based Material Decomposition Images With Dual-Energy Computed Tomography Imaging for Preoperatively Predicting Microsatellite Instability Status in Colorectal Cancer

(2019) Jingjun Wu et al.   Frontiers in Oncology

Immunotherapy with immune checkpoint inhibitors in colorectal cancer: what is the future beyond deficient mismatch-repair tumours?

(2019) Nicolas Huyghe et al.   Gastroenterology Report

Recent progress in Lynch syndrome and other familial colorectal cancer syndromes

(2018) Patrick M. Boland et al.   CA-A CANCER JOURNAL FOR CLINICIANS

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

(2018) Franck Pagès et al.   LANCET

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

(2018) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predicting cancer outcomes from histology and genomics using convolutional networks

(2018) Pooya Mobadersany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep learning based tissue analysis predicts outcome in colorectal cancer

(2018) Dmitrii Bychkov et al.   Scientific Reports

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

(2018) Joel Saltz et al.   Cell Reports

Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults

(2018) Talha Shaikh et al.   JAMA Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Computer-extracted features relating to spatial arrangement of tumor infiltrating lymphocytes to predict response to nivolumab in non-small cell lung cancer (NSCLC).

(2018) Cristian Barrera et al.   JOURNAL OF CLINICAL ONCOLOGY

A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study

(2018) Roger Sun et al.   LANCET ONCOLOGY

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

(2018) Nicolas Coudray et al.   NATURE MEDICINE

Global trends in colorectal cancer mortality: projections to the year 2035

(2018) Marzieh Araghi et al.   INTERNATIONAL JOURNAL OF CANCER

Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study

(2017) Seán O Hynes et al.   HISTOPATHOLOGY

Molecular Biomarkers for the Evaluation of Colorectal Cancer

(2017) Antonia R. Sepulveda et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project

(2017) Katrin M Sjoquist et al.   JNCI-Journal of the National Cancer Institute

Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring aPOLEMutation

(2017) Jun Gong et al.   Journal of the National Comprehensive Cancer Network

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project

(2017) Katrin M Sjoquist et al.   JNCI-Journal of the National Cancer Institute

Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age

(2017) Kenji Fujiyoshi et al.   Cancer Medicine

Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy

(2016) Etienne Becht et al.   CLINICAL CANCER RESEARCH

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

(2016) Bernhard Mlecnik et al.   IMMUNITY

Tumor-Infiltrating Lymphocytes, Crohn’s-Like Lymphoid Reaction, and Survival From Colorectal Cancer

(2016) Laura S. Rozek et al.   JNCI-Journal of the National Cancer Institute

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

Tumor-Infiltrating Lymphocytes, Crohn’s-Like Lymphoid Reaction, and Survival From Colorectal Cancer

(2016) Laura S. Rozek et al.   JNCI-Journal of the National Cancer Institute

Intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma is of limited value

(2016) Hendrik T.J. Mantel et al.   Cancer Medicine

Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy

(2015) Elizabeth M Webber et al.   BMC CANCER

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

(2015) T T Seppälä et al.   BRITISH JOURNAL OF CANCER

Using frozen section to identify histological patterns in stage I lung adenocarcinoma of ≤3 cm: accuracy and interobserver agreement

(2015) Yi-Chen Yeh et al.   HISTOPATHOLOGY

Deep learning

(2015) Yann LeCun et al.   NATURE

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenicity of somatic mutations in human gastrointestinal cancers

(2015) E. Tran et al.   SCIENCE

Programmed Cell Death 1 (PD-1) and Its Ligand (PD-L1) in Common Cancers and Their Correlation with Molecular Cancer Type

(2014) Z. Gatalica et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Microsatellite Instability Detection by Next Generation Sequencing

(2014) S. J. Salipante et al.   CLINICAL CHEMISTRY

Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers

(2013) Sarah Briggs et al.   JOURNAL OF PATHOLOGY

Can a gastrointestinal pathologist identify microsatellite instability in colorectal cancer with reproducibility and a high degree of specificity?

(2012) Eli Brazowski et al.   Familial Cancer

Validation Microsatellite Path Score in a Population-Based Cohort of Patients With Colorectal Cancer

(2011) Xavier Bessa et al.   JOURNAL OF CLINICAL ONCOLOGY

Nonsense Mediated Decay Resistant Mutations Are a Source of Expressed Mutant Proteins in Colon Cancer Cell Lines with Microsatellite Instability

(2011) David S. Williams et al.   PLoS One

A Histology-Based Model for Predicting Microsatellite Instability in Colorectal Cancers

(2010) Angela Hyde et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

(2010) Daniel J. Sargent et al.   JOURNAL OF CLINICAL ONCOLOGY

Microsatellite instability in colorectal cancer—the stable evidence

(2010) Eduardo Vilar et al.   Nature Reviews Clinical Oncology

Microsatellite instability of the colorectal carcinoma can be predicted in the conventional pathologic examination. A prospective multicentric study and the statistical analysis of 615 cases consolidate our previously proposed logistic regression model

(2010) Ruth Román et al.   VIRCHOWS ARCHIV

Equivalence of Protein Inventories Obtained from Formalin-fixed Paraffin-embedded and Frozen Tissue in Multidimensional Liquid Chromatography-Tandem Mass Spectrometry Shotgun Proteomic Analysis

(2009) Robert W. Sprung et al.   MOLECULAR & CELLULAR PROTEOMICS

Pathologic Predictors of Microsatellite Instability in Colorectal Cancer

(2008) Joel K. Greenson et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Molecular, Pathologic, and Clinical Features of Early-Onset Endometrial Cancer: Identifying Presumptive Lynch Syndrome Patients

(2008) M. D. Walsh et al.   CLINICAL CANCER RESEARCH

A procedure for tissue freezing and processing applicable to both intra-operative frozen section diagnosis and tissue banking in surgical pathology

(2008) Susanne Steu et al.   VIRCHOWS ARCHIV