Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development

Super‐Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons

(2020) Oxana Klementieva et al.   Advanced Science

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

(2020) Thomas C. T. Michaels et al.   Nature Chemistry

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

An open-source code for Mie extinction extended multiplicative signal correction for infrared microscopy spectra of cells and tissues

(2019) Johanne H. Solheim et al.   Journal of Biophotonics

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Detection of Aβ plaque-associated astrogliosis in Alzheimer's disease brain by spectroscopic imaging and immunohistochemistry

(2018) Francesca Palombo et al.   ANALYST

Synchrotron-Based Fourier Transform Infrared Microspectroscopy (μFTIR) Study on the Effect of Alzheimer’s Aβ Amorphous and Fibrillar Aggregates on PC12 Cells

(2018) Núria Benseny-Cases et al.   ANALYTICAL CHEMISTRY

Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy

(2018) Minbiao Ji et al.   Science Advances

An improved algorithm for fast resonant Mie scatter correction of infrared spectra of cells and tissues

(2017) Tatiana Konevskikh et al.   Journal of Biophotonics

Not All β-Sheets Are the Same: Amyloid Infrared Spectra, Transition Dipole Strengths, and Couplings Investigated by 2D IR Spectroscopy

(2017) Justin P. Lomont et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP

(2017) O. Klementieva et al.   Nature Communications

Spatial and molecular resolution of diffuse malignant mesothelioma heterogeneity by integrating label-free FTIR imaging, laser capture microdissection and proteomics

(2017) Frederik Großerueschkamp et al.   Scientific Reports

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients

(2017) Ralph Michael et al.   Scientific Reports

Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease

(2016) Andreas Nabers et al.   ANALYTICAL CHEMISTRY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Rapid biodiagnostic ex vivo imaging at 1 μm pixel resolution with thermal source FTIR FPA

(2015) C. R. Findlay et al.   ANALYST

Plaque-associated lipids in Alzheimer’s diseased brain tissue visualized by nonlinear microscopy

(2015) Juris Kiskis et al.   Scientific Reports

Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson’s disease patients

(2015) Katsuya Araki et al.   Scientific Reports

Microspectroscopy (μFTIR) Reveals Co-localization of Lipid Oxidation and Amyloid Plaques in Human Alzheimer Disease Brains

(2014) Núria Benseny-Cases et al.   ANALYTICAL CHEMISTRY

Synchrotron FTIR reveals lipid around and within amyloid plaques in transgenic mice and Alzheimer's disease brain

(2013) Catherine R. Liao et al.   ANALYST

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

(2013) Samir F. El-Mashtoly et al.   ANALYST

ATR-FTIR: A “rejuvenated” tool to investigate amyloid proteins

(2013) Rabia Sarroukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Infrared, Vibrational Circular Dichroism, and Raman Spectral Simulations for β-Sheet Structures with Various Isotopic Labels, Interstrand, and Stacking Arrangements Using Density Functional Theory

(2013) William R. W. Welch et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Common Mechanism in Alzheimer’s Disease and Prion Amyloidosis: Amyloid-Associated Proteins, Neuroinflammation and Neurofibrillary Degeneration

(2012) Annemieke J.M. Rozemuller et al.   Neurodegenerative Diseases

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Morphologically distinct types of amyloid plaques point the way to a better understanding of Alzheimer’s disease pathogenesis

(2010) MR D’Andrea et al.   BIOTECHNIC & HISTOCHEMISTRY

Transformation of amyloid β(1–40) oligomers into fibrils is characterized by a major change in secondary structure

(2010) Rabia Sarroukh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

(2009) Andreana C. Leskovjan et al.   NEUROIMAGE

Secondary structure of lipidated Ras bound to a lipid bilayer

(2008) Jörn Güldenhaupt et al.   FEBS Journal

Quantification of brain lipids by FTIR spectroscopy and partial least squares regression

(2008) Isabell Dreissig et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE