Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation

(2020) Chen-Chen Han et al.   CLINICAL SCIENCE

A network pharmacology approach to explore the potential targets underlying the effect of sinomenine on rheumatoid arthritis

(2020) Xiang Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis

(2019) Xiao-yi Jia et al.   ACTA PHARMACOLOGICA SINICA

Th1/Th17 Cytokine Profile is Induced by Macrophage Migration Inhibitory Factor in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients

(2019) Samuel García-Arellano et al.   CURRENT MOLECULAR MEDICINE

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes

(2019) Jin Lin et al.   Journal of Immunology Research

Apolipoprotein B binds to enolase-1 and aggravates inflammation in rheumatoid arthritis

(2018) Joo Youn Lee et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunomodulatory Effects of CP-25 on Splenic T Cells of Rats with Adjuvant Arthritis

(2018) Yang Wang et al.   INFLAMMATION

Paeoniflorin-6′-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents

(2018) Jin-ling Shu et al.   ACTA PHARMACOLOGICA SINICA

CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation

(2018) Xuezhi Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

(2017) Helen V. Waldschmidt et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis

(2017) Federico Biscetti et al.   MEDIATORS OF INFLAMMATION

Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis

(2017) Qingtong Wang et al.   Scientific Reports

CP-25, a Novel Anti-inflammatory and Immunomodulatory Drug, Inhibits the Functions of Activated Human B Cells through Regulating BAFF and TNF-alpha Signaling and Comparative Efficacy with Biological Agents

(2017) Feng Zhang et al.   Frontiers in Pharmacology

Hypothesis

(2016) Jonathan M. Powell et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

(2016) Helen V. Waldschmidt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration

(2016) Chun Wang et al.   XENOBIOTICA

Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)

(2016) Feiyang Liu et al.   Oncotarget

CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage

(2016) Yan Chang et al.   Scientific Reports

Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice

(2015) Joshua Abd Alla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative proteomics reveals ELP2 as a regulator to the inhibitory effect of TNF-α on osteoblast differentiation

(2015) Chang-Peng Xu et al.   Journal of Proteomics

Cellular imaging in rheumatic diseases

(2015) Robert A. Benson et al.   Nature Reviews Rheumatology

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

(2015) Sarah M. Schumacher et al.   Science Translational Medicine

Absorption characteristic of paeoniflorin-6′-O-benzene sulfonate (CP-25) inin situsingle-pass intestinal perfusion in rats

(2015) Xiao-Dan Yang et al.   XENOBIOTICA

Medically Significant Infections Are Increased in Patients With Juvenile Idiopathic Arthritis Treated With Etanercept: Results From the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study

(2015) Rebecca Davies et al.   Arthritis & Rheumatology

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

(2014) Kristoff T. Homan et al.   ACS Chemical Biology

The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats

(2013) Dong-Yang Liu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Novel coumarin-dihydropyrazole thio-ethanone derivatives: Design, synthesis and anticancer activity

(2013) Xiao-Qin Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Are We Being Open Enough to All Approaches to Therapy of Rheumatoid Arthritis?

(2013) H. Ralph Schumacher   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Emerging cell and cytokine targets in rheumatoid arthritis

(2013) Gerd R. Burmester et al.   Nature Reviews Rheumatology

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

(2012) David M. Thal et al.   ACS Chemical Biology

Combined use of etanercept and MTX restores CD4+/CD8+ ratio and Tregs in spleen and thymus in collagen-induced arthritis

(2012) B. Huang et al.   INFLAMMATION RESEARCH

BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin

(2012) Pei-Pei Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Towards the next generation of anti-TNF drugs

(2011) Petros P. Sfikakis et al.   CLINICAL IMMUNOLOGY

Synovial expression of Th17-related and cancer-associated genes is regulated by the arthritis severity locus Cia10

(2011) E Jenkins et al.   GENES AND IMMUNITY

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

(2011) D. M. Thal et al.   MOLECULAR PHARMACOLOGY

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

(2010) Petronila Penela et al.   BRITISH JOURNAL OF PHARMACOLOGY

The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony

(2010) Qing-Tong Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

(2010) John J. G. Tesmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic effects of TACI-Ig on rats with adjuvant-induced arthritis via attenuating inflammatory responses

(2010) Yan Chang et al.   RHEUMATOLOGY

Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis

(2009) Masayoshi Katano et al.   ARTHRITIS RESEARCH & THERAPY

Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature

(2008) K Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast – like synoviocytes of collagen induced arthritic rats

(2008) L.-L. Zhang et al.   INFLAMMATION RESEARCH