Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283

Connexins in cancer: bridging the gap to the clinic

(2019) Trond Aasen et al.   ONCOGENE

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

(2019) Anne Dirkse et al.   Nature Communications

Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer

(2019) Sehui Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The connexin 43 C-terminus: A tail of many tales

(2018) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

(2018) Benjamin Kleaveland et al.   CELL

Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics

(2018) Christina L Grek et al.   CURRENT OPINION IN PHARMACOLOGY

The nutrient environment affects therapy

(2018) Alexander Muir et al.   SCIENCE

Cancer Stem Cell Metabolism and Potential Therapeutic Targets

(2018) Vusala Snyder et al.   Frontiers in Oncology

Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy

(2018) Thibault Le Bourgeois et al.   Frontiers in Oncology

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

(2017) H-Q Ju et al.   ONCOGENE

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

(2017) Jia Zhang et al.   Nature Communications

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

(2017) Vera Miranda-Gonçalves et al.   Oncotarget

Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

(2017) Davinder Singh et al.   Cell and Bioscience

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

(2017) Alexander Muir et al.   eLife

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

(2017) Myriam Jaraíz-Rodríguez et al.   Jove-Journal of Visualized Experiments

A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK

(2017) Myriam Jaraíz-Rodríguez et al.   Stem Cell Reports

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration

(2016) Chanjuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

The role of connexin43–Src interaction in astrocytomas: A molecular puzzle

(2016) A. Tabernero et al.   NEUROSCIENCE

Proteome and Secretome Characterization of Glioblastoma-Derived Neural Stem Cells

(2016) Satoshi Okawa et al.   STEM CELLS

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes

(2016) Ana González-Sánchez et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

(2015) S. Jain et al.   CANCER RESEARCH

Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide

(2015) S. F. Murphy et al.   CANCER RESEARCH

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

The metabolic landscape of cancer stem cells

(2015) Ilaria Dando et al.   IUBMB LIFE

Differential Connexin Function Enhances Self-Renewal in Glioblastoma

(2015) Masahiro Hitomi et al.   Cell Reports

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

(2014) Fred Fack et al.   ACTA NEUROPATHOLOGICA

Oleic acid synthesized by stearoyl-CoA desaturase (SCD-1) in the lateral periventricular zone of the developing rat brain mediates neuronal growth, migration and the arrangement of prospective synapses

(2014) Erica Polo-Hernández et al.   BRAIN RESEARCH

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

The role of Src family kinases in growth and migration of glioma stem cells

(2014) XIAOSI HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid Analysis of Glycolytic and Oxidative Substrate Flux of Cancer Cells in a Microplate

(2014) Lisa S. Pike Winer et al.   PLoS One

A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype

(2014) E Gangoso et al.   Cell Death & Disease

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway

(2013) Paul R. Gielen et al.   NEUROPHARMACOLOGY

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

(2013) Y. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

(2012) Sandeep Singh et al.   Molecular Cancer

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

HIF-1 and c-Src Mediate Increased Glucose Uptake Induced by Endothelin-1 and Connexin43 in Astrocytes

(2012) José Carlos Valle-Casuso et al.   PLoS One

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activity-Dependent Regulation of Surface Glucose Transporter-3

(2011) J. M. Ferreira et al.   JOURNAL OF NEUROSCIENCE

Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays

(2011) Lilian Hook et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E-Cadherin

(2011) Shi-Cang Yu et al.   STEM CELLS

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells

(2010) S Herrero-González et al.   ONCOGENE

Glucose 6-Phosphate Dehydrogenase Is Regulated Through c-Src–Mediated Tyrosine Phosphorylation in Endothelial Cells

(2009) Shi Pan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes

(2009) Luis Felipe Barros et al.   JOURNAL OF NEUROCHEMISTRY

Localization of PTP-1B, SHP-2, and Src Exclusively in Rat Brain Mitochondria and Functional Consequences

(2008) Amal Arachiche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY