Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA

PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

(2020) Sodiomon B Sirima et al.   LANCET INFECTIOUS DISEASES

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding

(2020) Maria C. Bewley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

(2019) Benjamin Mordmüller et al.   CLINICAL INFECTIOUS DISEASES

Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential

(2019) Nichole D. Salina et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA

(2019) Dominique Dorin-Semblat et al.   PLOS BIOLOGY

Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

(2019) Frank Lennartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DALI and the persistence of protein shape

(2019) Liisa Holm   PROTEIN SCIENCE

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA

(2019) Catherine J. Mitran et al.   mBio

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development

(2018) Arnaud Chêne et al.   npj Vaccines

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

(2018) Mette Ø. Agerbæk et al.   Nature Communications

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Fighting Cancer Using an Oncofetal Glycosaminoglycan-Binding Protein from Malaria Parasites

(2018) Mette Ø. Agerbæk et al.   TRENDS IN PARASITOLOGY

Cancer–malaria: hidden connections

(2018) Akpéli V. Nordor et al.   Open Biology

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

(2017) Mats Wahlgren et al.   NATURE REVIEWS MICROBIOLOGY

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Malaria during Pregnancy

(2017) Michal Fried et al.   Cold Spring Harbor Perspectives in Medicine

Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions

(2017) Erin E. Cutts et al.   PLoS Pathogens

Modeling cytoadhesion ofPlasmodium falciparum-infected erythrocytes and leukocytes-common principles and distinctive features

(2016) Gesa Helms et al.   FEBS LETTERS

VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies toPlasmodium falciparumPlacental Malaria

(2016) Justin Yai Alamou Doritchamou et al.   JOURNAL OF INFECTIOUS DISEASES

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

(2016) Arnaud Chêne et al.   MALARIA JOURNAL

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

(2016) Reetesh Raj Akhouri et al.   Cell Reports

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

(2015) Ali Salanti et al.   CANCER CELL

Investigating the function of Fc-specific binding of IgM toPlasmodium falciparumerythrocyte membrane protein 1 mediating erythrocyte rosetting

(2015) Liz Stevenson et al.   CELLULAR MICROBIOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Designing a VAR2CSA-based vaccine to prevent placental malaria

(2015) Michal Fried et al.   VACCINE

Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions

(2015) Stéphane Gangnard et al.   Scientific Reports

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

The Antibody Response of Pregnant Cameroonian Women to VAR2CSA ID1-ID2a, a Small Recombinant Protein Containing the CSA-Binding Site

(2014) Anna Babakhanyan et al.   PLoS One

Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC

(2014) Joseph D. Batchelor et al.   PLoS Pathogens

Molecular Architecture of a Complex between an Adhesion Protein from the Malaria Parasite and Intracellular Adhesion Molecule 1

(2013) Alan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Sialic Acid-dependent Receptor Recognition by thePlasmodium falciparumInvasion Protein Erythrocyte-binding Antigen-140/BAEBL

(2013) Brian M. Malpede et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Immunological Correlations between the Variable Blocks of the VAR2CSA Domain DBL6ε from Two Plasmodium falciparum Parasite Lines

(2013) Stéphane Gangnard et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural insights into proteoglycan-shaped Hedgehog signaling

(2013) D. M. Whalen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA

(2013) Justin Doritchamou et al.   VACCINE

Structural and Functional Insight into How thePlasmodium falciparumVAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

(2012) Thomas M. Clausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of B-Cell Epitopes in the DBL4ε Domain of VAR2CSA

(2012) Sisse B. Ditlev et al.   PLoS One

Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum Rosetting

(2012) Inès Vigan-Womas et al.   PLoS Pathogens

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains

(2011) Madeleine Dahlbäck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region

(2011) Anand Srivastava et al.   PLoS One

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

(2010) A. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites

(2009) Mafalda Resende et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy

(2009) Pongsak Khunrae et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiple var2csa-Type PfEMP1 Genes Located at Different Chromosomal Loci Occur in Many Plasmodium falciparum Isolates

(2009) Adam F. Sander et al.   PLoS One

Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSA

(2008) M. Avril et al.   INFECTION AND IMMUNITY

PfEMP1: An antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum

(2008) Noa D. Pasternak et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

(2008) Matthew K. Higgins   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

(2008) Kavita Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Insight into Epitopes in the Pregnancy-Associated Malaria Protein VAR2CSA

(2008) Pernille Andersen et al.   PLoS Pathogens