Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase

κ‑opioid receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF‑κB/HIF‑1α pathway

(2020) Xiaoyan Zhang et al.   Experimental and Therapeutic Medicine

Fortifying diet with rapeseed oil instead of butterfat attenuates the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) and impairment of glucose tolerance

(2020) Annette Brandt et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Arginase impedes the resolution of colitis by altering the microbiome and metabolome

(2020) Julia Baier et al.   JOURNAL OF CLINICAL INVESTIGATION

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak

(2019) Irene Gramaglia et al.   PLoS One

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP 2E1‐Mediated Oxidative and Nitrative Stress

(2019) Young‐Eun Cho et al.   HEPATOLOGY

Heterologous Expression of Argininosuccinate Synthase From Oenococcus oeni Enhances the Acid Resistance of Lactobacillus plantarum

(2019) Hongyu Zhao et al.   Frontiers in Microbiology

Risk Factors for the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Genetics

(2018) Huei-Wen Lim et al.   Clinics in Liver Disease

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

l -Citrulline restores nitric oxide level and cellular uptake at the brain capillary endothelial cell line (TR-BBB cells) with glutamate cytotoxicity

(2018) Kyeong-Eun Lee et al.   MICROVASCULAR RESEARCH

Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence

(2018) Tomoe Tsuboi et al.   PLoS One

Modulation of gut microbiome in nonalcoholic fatty liver disease: pro-, pre-, syn-, and antibiotics

(2018) Min Seok Cho et al.   JOURNAL OF MICROBIOLOGY

Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice

(2017) Cheng Jun Jin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment

(2017) Annette Brandt et al.   Nutrients

Effect of Bacillus subtilis and Bacillus licheniformis supplementation in diets with low- and high-protein content on ileal crude protein and amino acid digestibility and intestinal microbiota composition of growing pigs

(2017) Chanwit Kaewtapee et al.   Journal of Animal Science and Biotechnology

Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children

(2017) Anika Nier et al.   PLoS One

Citrulline in health and disease. Review on human studies

(2017) Cinzia Papadia et al.   CLINICAL NUTRITION

Effects of Dexmedetomidine on Intestinal Microcirculation and Intestinal Epithelial Barrier in Endotoxemic Rats

(2016) Yu-Chang Yeh et al.   ANESTHESIOLOGY

Preventive effects of citrulline on Western diet-induced non-alcoholic fatty liver disease in rats

(2016) Prasanthi Jegatheesan et al.   BRITISH JOURNAL OF NUTRITION

Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction

(2016) Oskar Kövamees et al.   Diabetes & Vascular Disease Research

Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD)

(2016) Cathrin Sellmann et al.   EUROPEAN JOURNAL OF NUTRITION

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

(2016) Giulio Marchesini et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

An Animal Model for the Juvenile Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

(2016) Veronica Marin et al.   PLoS One

Distinctly altered gut microbiota in the progression of liver disease

(2016) Guoxiang Xie et al.   Oncotarget

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Rescue Treatment with L-Citrulline Inhibits Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs

(2015) Candice D. Fike et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)

(2015) Cheng Jun Jin et al.   BRITISH JOURNAL OF NUTRITION

Combining citrulline with atorvastatin preserves glucose homeostasis in a murine model of diet-induced obesity

(2015) Frédéric Capel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis

(2015) Cathrin Sellmann et al.   JOURNAL OF NUTRITION

Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time

(2015) Cathrin Sellmann et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Citrulline Supplementation Improves Organ Perfusion and Arginine Availability under Conditions with Enhanced Arginase Activity

(2015) Karolina Wijnands et al.   Nutrients

Nitrate Reduction to Nitrite, Nitric Oxide and Ammonia by Gut Bacteria under Physiological Conditions

(2015) Mauro Tiso et al.   PLoS One

Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia

(2014) Karolina A. P. Wijnands et al.   PLoS One

Glucose transport into everted sacs of the small intestine of mice

(2013) Kirk L. Hamilton et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

(2013) James J. Kozich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease

(2013) Giridhar Kanuri et al.   LIVER INTERNATIONAL

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(2013) Astrid Spruss et al.   MOLECULAR MEDICINE

Protein Kinase C-α and Arginase I Mediate Pneumolysin-Induced Pulmonary Endothelial Hyperpermeability

(2012) Rudolf Lucas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

(2012) Valentina Volynets et al.   DIGESTIVE DISEASES AND SCIENCES

Inhibition of arginase ameliorates experimental ulcerative colitis in mice

(2012) Y. Akazawa et al.   FREE RADICAL RESEARCH

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

(2012) Jérôme Badaut et al.   Journal of Neuroinflammation

Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function

(2012) Astrid Spruss et al.   LABORATORY INVESTIGATION

Differences in iNOS and Arginase Expression and Activity in the Macrophages of Rats Are Responsible for the Resistance against T. gondii Infection

(2012) Zhi Li et al.   PLoS One

Citrulline a More Suitable Substrate than Arginine to Restore NO Production and the Microcirculation during Endotoxemia

(2012) Karolina A. P. Wijnands et al.   PLoS One

Toll-like receptors 1–9 are elevated in livers with fructose-induced hepatic steatosis

(2011) Sabine Wagnerberger et al.   BRITISH JOURNAL OF NUTRITION

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes

(2008) Eleonore S Köhler et al.   BMC DEVELOPMENTAL BIOLOGY

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS’ role in disease

(2008) Olga V. Nemirovskiy et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY