Article
Medicine, Research & Experimental
Jason Sadek, Derek T. Hall, Bianca Colalillo, Amr Omer, Anne-Marie K. Tremblay, Virginie Sanguin-Gendreau, William Muller, Sergio Di Marco, Marco Emilio Bianchi, Imed-Eddine Gallouzi
Summary: The study reveals that iNOS induces muscle wasting in cachexia by disrupting mitochondrial function and energy production processes. Clinically tested iNOS inhibitor GW274150 shows protective effects against muscle wasting in septic and cancer cachexia models.
EMBO MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yudong Xia, Xiaoying Zhai, Yanning Qiu, Xuemei Lu, Yi Jiao
Summary: This review explores the complex interplay among Nrf2, oxidative stress, lipid metabolism, insulin signaling, and chronic inflammation in obesity, aiming to provide new insights for the treatment of obesity and its comorbidities.
Article
Immunology
Justyna Dorf, Konrad Zareba, Joanna Matowicka-Karna, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz, Anna Zalewska, Mateusz Maciejczyk
Summary: The study evaluated the differences in nitrosative stress, protein and DNA oxidation/glycoxidation, as well as pro- and anti-inflammatory cytokines between CRC patients and healthy controls. The results showed that oxidation and glycoxidation products in CRC patients were positively correlated with pro-inflammatory and anti-inflammatory cytokines, indicating that redox damages may promote inflammation in CRC.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Siva R. Uppalapati, Andres Vazquez-Torres
Summary: The metal ion manganese (Mn2+) is important for both hosts and bacterial pathogens. Hosts restrict Mn2+ to combat bacterial infection, while pathogens have mechanisms to counteract this restriction. Mn2+ serves as a cofactor in antioxidant defense and central metabolism. Bacterial pathogens prefer Mn2+-cofactored enzymes during oxidative stress. Mn2+ catalyzes metabolic pathways that provide outputs related to Salmonella's resistance against reactive oxygen species generated during the respiratory burst.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Francisco Anta-Fernandez, Daniela Santander-Gordon, Sioly Becerra, Rodrigo Santamaria, Jose Maria Diaz-Minguez, Ernesto Perez Benito
Summary: Nitric oxide (NO) has been found to regulate various physiological processes in the early developmental stages of the fungal necrotroph Botrytis cinerea. The study showed that NO modulates germination, germ tube elongation, and nuclear division rate. The effect of exogenous NO on the fungus was immediate but transitory, with a negative impact on germination-associated processes. The flavohemoglobin BCFHG1 was found to play a significant role in mediating this effect. The study also revealed the upregulation of defense mechanisms and nitrate assimilation genes in response to NO.
Article
Biochemistry & Molecular Biology
Karol Momot, Kamil Krauz, Katarzyna Czarzasta, Maciej Zarebinski, Liana Puchalska, Malgorzata Wojciechowska
Summary: Heart failure (HF) is a complex syndrome characterized by impaired cardiac function, with two common subtypes being heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). This study aimed to evaluate and compare plasma levels of 3-nitrotyrosine (3-NT) as a marker of nitrosative/oxidative stress and myeloperoxidase (MPO) as an indicator of inflammation between HFpEF and HFrEF patients. The results showed significantly higher levels of 3-NT in HFpEF patients compared to the control group and the HFrEF group, indicating intensified nitrosative/oxidative stress in HFpEF but not in HFrEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaoyu Pan, Lin Yue, Jiangli Ban, Lin Ren, Shuchun Chen
Summary: The study found that semaglutide has a significant impact on cardiac protein expression in obese mice, alleviating obesity-induced cardiac issues and reducing levels of inflammation and oxidative stress. Proteomics analysis revealed that DEPs are mainly associated with lipid metabolism and peroxisomes.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Immunology
Gerwyn Morris, Maria Gevezova, Victoria Sarafian, Michael Maes
Summary: The immune-inflammatory response is associated with increased nitro-oxidative stress. Redox-associated mechanisms play a crucial role in modulating various aspects of the immune response. Chronic nitro-oxidative stress can have detrimental effects on immune cells and their functions.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Consiglia Longobardi, Sara Damiano, Emanuela Andretta, Francesco Prisco, Valeria Russo, Francesco Pagnini, Salvatore Florio, Roberto Ciarcia
Summary: The study demonstrated that curcumin has cytoprotective and antioxidant activities against OTA-induced nephrotoxicity and hepatotoxicity in rats by regulating inflammation, reducing nitric oxide levels, and decreasing oxidative DNA damage.
Article
Biochemistry & Molecular Biology
Michael Maes, Decio Sabbatini Barbosa, Abbas F. Almulla, Buranee Kanchanatawan
Summary: This study aimed to develop a precision medicine model for temporal lobe epilepsy (TLE) and associated mental comorbidities. The results showed that oxidative stress and antioxidant biomarkers could explain a large part of the variability in TLE and psychopathology features. Based on these findings, a new phenotype class was constructed, characterized by increased severity of TLE, psychopathology, and oxidative stress features, and decreased antioxidant defenses. Furthermore, increased levels of malondialdehyde, decreased antioxidants, and nitric oxide metabolites were associated with increased episode frequency.
Article
Biochemistry & Molecular Biology
Dhafer Y. Alhareth, Abdulrazaq Alanazi, Wael A. Alanazi, Mushtaq A. Ansari, Mahmoud N. Nagi, Sheikh F. Ahmad, Mohamed S. M. Attia, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia
Summary: This study found that the proteasome inhibitor carfilzomib can protect against acute liver failure (ALF) induced by LPS/GalN/DMSO in mice by inhibiting NF-kB, reducing inflammatory mediators, oxidative stress, and apoptosis, suggesting its potential as a therapeutic agent for ALF.
Review
Biochemistry & Molecular Biology
Pei-Chi Chan, Po-Shiuan Hsieh
Summary: Obesity is characterized by excessive accumulation of adipose tissue with alterations in immune and metabolic responses. The role of chemokines and chemokine receptors in obesity-related inflammation and metabolism dysregulation is complex and not fully understood. Understanding these mechanisms could lead to potential therapeutic targets for controlling immune and metabolic disorders associated with obesity in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Joanna M. Wieronska, Paulina Cieslik, Leszek Kalinowski
Summary: Nitric oxide plays a crucial role in the development of pathological changes and detrimental processes in the aftermath of stroke. These processes include the production of ROS/RNS, neuronal toxicity, activation of inflammatory cells, and nitrosative stress.
Review
Cardiac & Cardiovascular Systems
Gabriele G. Schiattarella, Daniele Rodolico, Joseph A. Hill
Summary: HFpEF is a common chronic cardiovascular disease, where metabolic disturbance and inflammatory burden play important roles in its pathogenesis. The interplay between these two processes is complex, with metabolic inflammation having a central role in shaping the pathophysiology of HFpEF.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Verena Wilmes, Ivan M. Kur, Andreas Weigert, Marcel A. Verhoff, Elise Gradhand, Silke Kauferstein
Summary: This study examines the expression of iNOS and NT production in postmortem human myocardial infarction hearts. The results demonstrate that resident macrophages are the main source of iNOS expression in these hearts, and there is a correlation between iNOS and NT production, indicating the involvement of iNOS in oxidative stress.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Geoffrey E. Hespe, Catherine L. Ly, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Surgery
Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Medical Laboratory Technology
Catherine L. Ly, Gabriela D. Garcia Nores, Raghu P. Kataru, Babak J. Mehrara
TRANSLATIONAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Shiri Gur-Cohen, Hanseul Yang, Sanjeethan C. Baksh, Yuxuan Miao, John Levorse, Raghu P. Kataru, Xiaolei Liu, June de la Cruz-Racelis, Babak J. Mehrara, Elaine Fuchs
Article
Cell Biology
Elizabeth J. Haining, Kate L. Lowe, Surasak Wichaiyo, Raghu P. Kataru, Zoltan Nagy, Dean Pj Kavanagh, Sian Lax, Ying Di, Bernhard Nieswandt, Benoit Ho-Tin-Noe, Babak J. Mehrara, Yotis A. Senis, Julie Rayes, Steve P. Watson
Summary: The study found that CLEC-2 expression on platelets is not necessary to maintain a barrier between the blood and lymphatic systems in unchallenged mice, but deficiency in CLEC-2 can lead to lymphatic vessel blood filling under conditions of chronic vascular remodeling. CLEC-2-driven platelet activation plays an essential role in vascular developmental programs.
Review
Biochemistry & Molecular Biology
Claire Y. Li, Raghu P. Kataru, Babak J. Mehrara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Physiology
Raghu P. Kataru, Hyeong Ju Park, Jung Eun Baik, Claire Li, Jinyeon Shin, Babak J. Mehrara
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Surgery
Catherine L. Ly, Sumun Khetpal, Danielle R. Heller, Susan A. Higgins, Brigid Killelea, Michael Alperovich, Tomer Avraham
Summary: This study compared irradiated free-flaps to non-irradiated internal controls in breast cancer patients undergoing reconstruction and PMRT. While PMRT may increase fibrosis in free-flaps, it does not significantly affect overall complications or revision surgeries. However, increased counseling may be necessary if internal mammary node irradiation is likely due to potential complications.
Article
Biochemistry & Molecular Biology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Catherine L. Ly, Jinyeon Shin, Noa Schwartz, Theresa T. Lu, Sagrario Ortega, Babak J. Mehrara
Summary: The study shows that intracellular modulation of the VEGF-C signaling pathway can induce the formation of functional lymphatic networks without off-target effects and inflammation.
Article
Multidisciplinary Sciences
Daniel Szoke, Gabor Kovacs, Eva Kemecsei, Laszlo Balint, Kitti Szotak-Ajtay, Petra Aradi, Andrea Styevkone Dinnyes, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Kariko, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltan Jakus
Summary: Dysfunction of the lymphatic system leads to secondary lymphedema and decreases quality of life. Researchers demonstrate that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Babak J. Mehrara, Hyeung Ju Park, Raghu P. Kataru, Jacqueline Bromberg, Michelle Coriddi, Jung Eun Baik, Jinyeon Shin, Claire Li, Michele R. Cavalli, Elizabeth M. Encarnacion, Meghan Lee, Kimberly J. Van Zee, Elyn Riedel, Joseph H. Dayan
Summary: The study aimed to examine the effect of inhibiting Th2 inflammation in lymphedema by using QBX258, a combination of IL4/13 neutralizing antibodies, and found that it improved quality of life and reduced pathological skin changes in women with breast cancer-related lymphedema. Treatment with QBX258 showed improvements in skin stiffness and quality of life measurements, particularly in physical and social aspects, with histological evidence of decreased epidermal changes and cytokine expression in lymphedematous skin.
Review
Immunology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Itay Wiser, Sonia Rehal, Jin Yeon Shin, Babak J. Mehrara
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)