Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

(2020) Elliot D. Mock et al.   Nature Chemical Biology

Oleoylethanolamide supplementation in obese patients newly diagnosed with non-alcoholic fatty liver disease: Effects on metabolic parameters, anthropometric indices, and expression of PPAR-α, UCP1, and UCP2 genes

(2020) Helda Tutunchi et al.   PHARMACOLOGICAL RESEARCH

Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues

(2019) Inigo Ruiz de Azua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes

(2019) Dana Sherill-Rofe et al.   GENOME RESEARCH

Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach

(2019) Enrico D'Aniello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

miRNAs and NAFLD: from pathophysiology to therapy

(2019) Monika Gjorgjieva et al.   GUT

Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet‐induced obese mice

(2019) Chiara Annunziata et al.   FASEB JOURNAL

Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation

(2018) Dawei Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine

(2018) Jelena Krstic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

(2018) Mireia López-Riera et al.   Scientific Reports

Non-alcoholic fatty liver disease: beyond the liver is an emerging multifaceted systemic disease

(2018) Luigi Elio Adinolfi et al.   HEPATOBILIARY SURGERY AND NUTRITION

Next-Generation Sequencing Identifies a Highly Accurate miRNA Panel That Distinguishes Well-Differentiated Thyroid Cancer from Benign Thyroid Nodules

(2018) Haggi Mazeh et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans

(2018) Shahar Azar et al.   OBESITY SURGERY

Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure via Sirt1/mTORC2 and AMPK Signaling

(2018) Jie Liu et al.   HEPATOLOGY

p53 as a double-edged sword in the progression of non-alcoholic fatty liver disease

(2018) Zhibin Yan et al.   LIFE SCIENCES

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers

(2017) Dorothea Portius et al.   PPAR Research

Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells

(2017) Kishor Pant et al.   Redox Biology

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

MicroRNA Control of p53

(2016) Juan Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data

(2016) Shani Ben-Ari Fuchs et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats

(2015) Long Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles

(2015) Ilyas R. Sadreyev et al.   NUCLEIC ACIDS RESEARCH

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

Fenofibrate Treatment Attenuated Chronic Endoplasmic Reticulum Stress in the Liver of Nonalcoholic Fatty Liver Disease Mice

(2015) Nan Zhang et al.   PHARMACOLOGY

miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1

(2015) Hanchun Chen et al.   TUMOR BIOLOGY

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

(2015) Jiexia Ding et al.   Scientific Reports

MicroRNAs in Nonalcoholic Fatty Liver Disease

(2015) György Baffy   Journal of Clinical Medicine

Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity

(2014) Joseph Tam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress

(2013) Jonathan Chang et al.   EMBO JOURNAL

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

(2013) Dotan Uzi et al.   JOURNAL OF HEPATOLOGY

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling

(2013) Y. Tabach et al.   Molecular Systems Biology

Regulation of SIRT1 by MicroRNAs

(2013) Sung-E Choi et al.   MOLECULES AND CELLS

microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription

(2013) Priyatansh Gurha et al.   PLoS One

Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

(2012) Jie Liu et al.   GASTROENTEROLOGY

Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition

(2012) Rui-Hong Wang et al.   International Journal of Biological Sciences

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing

(2012) Thalia A. Farazi et al.   METHODS

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence

(2012) Yuval Tabach et al.   NATURE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Anti-obesity efficacy of LH-21, a cannabinoid CB1 receptor antagonist with poor brain penetration, in diet-induced obese rats

(2011) Mónica Alonso et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21

(2011) N. Tsuchiya et al.   CANCER RESEARCH

Rimonabant improves cholesterol, insulin resistance and markers of non-alcoholic fatty liver in morbidly obese patients: a retrospective cohort study

(2011) A. S. Wierzbicki et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice

(2010) T. Jourdan et al.   DIABETES

Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation

(2010) Fen Xu et al.   ENDOCRINOLOGY

Endocannabinoids in liver disease

(2010) Joseph Tam et al.   HEPATOLOGY

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients

(2010) Giovanni Annuzzi et al.   Lipids in Health and Disease

Genome-wide Expression Profiling Revealed Peripheral Effects of Cannabinoid Receptor 1 Inverse Agonists in Improving Insulin Sensitivity and Metabolic Parameters

(2010) W. Zhao et al.   MOLECULAR PHARMACOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-α Ligands in Zucker Rats

(2009) Angelo A. Izzo et al.   Obesity

Effect of Rimonabant on the High-Triglyceride/ Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat

(2008) Jean-Pierre Després et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Central Versus Peripheral Antagonism of Cannabinoid CB1 Receptor in Obesity: Effects of LH-21, a Peripherally Acting Neutral Cannabinoid Receptor Antagonist, in Zucker Rats

(2008) F. J. Pavón et al.   JOURNAL OF NEUROENDOCRINOLOGY

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

(2008) Dimitrios Iliopoulos et al.   PLoS One

The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats

(2007) Antonia Serrano et al.   NEUROPHARMACOLOGY