Anti-obesity efficacy of LH-21, a cannabinoid CB1 receptor antagonist with poor brain penetration, in diet-induced obese rats

The case for peripheral CB1receptor blockade in the treatment of visceral obesity and its cardiometabolic complications

(2011) George Kunos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1receptor blockade

(2010) Ana Crespillo et al.   BIOCHEMICAL JOURNAL

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

(2010) NL Cluny et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice

(2010) T. Jourdan et al.   DIABETES

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity

(2010) F. D. Christopoulou et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Leptin, Leptin Receptors, and the Control of Body Weight

(2010) Jeffrey M. Friedman   NUTRITION REVIEWS

The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior

(2010) P.A. Randall et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat

(2010) Nina L. Cluny et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The role of the endocannabinoid system in lipogenesis and fatty acid metabolism

(2009) Roberto Vettor et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

(2009) Gernot Riedel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding

(2009) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands

(2009) Ankur Kapur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding

(2009) M K Judge et al.   JOURNAL OF ENDOCRINOLOGY

Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-α Ligands in Zucker Rats

(2009) Angelo A. Izzo et al.   Obesity

Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents

(2008) Mario Alvarado et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods

(2008) Laura Hernandez-Folgado et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

(2008) Jesse LoVerme et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The endocannabinoid system in obesity and type 2 diabetes

(2008) V. Di Marzo   DIABETOLOGIA

Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor

(2008) Richard Z. Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The GPR55 ligand l-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

(2008) Christopher M. Henstridge et al.   FASEB JOURNAL

Central Versus Peripheral Antagonism of Cannabinoid CB1 Receptor in Obesity: Effects of LH-21, a Peripherally Acting Neutral Cannabinoid Receptor Antagonist, in Zucker Rats

(2008) F. J. Pavón et al.   JOURNAL OF NEUROENDOCRINOLOGY

Cannabinoid Type 1 Receptor: Another Arrow in the Adipocytes’ Bow

(2008) L. Bellocchio et al.   JOURNAL OF NEUROENDOCRINOLOGY

Dysregulation of the Endocannabinoid System in Obesity

(2008) S. Engeli   JOURNAL OF NEUROENDOCRINOLOGY

Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets

(2008) Isabel Matias et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet

(2008) Katarzyna M. Starowicz et al.   Obesity