Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

(2020) Franziska Herster et al.   Nature Communications

Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis

(2020) Cynthia M. de Bont et al.   JOURNAL OF AUTOIMMUNITY

Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

(2020) Svend Birkelund et al.   Clinical Proteomics

Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis

(2020) Carmelo Carmona-Rivera et al.   JCI Insight

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Metabolic Insight of Neutrophils in Health and Disease

(2019) Sachin Kumar et al.   Frontiers in Immunology

Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation

(2019) Shailesh Agarwal et al.   Frontiers in Immunology

Association between levels of synovial anti-citrullinated peptide antibodies and neutrophil response in patients with rheumatoid arthritis

(2018) Carolina V. Gorlino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation status of peripheral blood neutrophils and the complement system in adult rheumatoid arthritis patients undergoing combined therapy with infliximab and methotrexate

(2018) Larissa F. Marchi et al.   RHEUMATOLOGY INTERNATIONAL

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation

(2018) Elmar Pieterse et al.   ANNALS OF THE RHEUMATIC DISEASES

1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints

(2018) James R. Anderson et al.   JOURNAL OF PROTEOME RESEARCH

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

(2017) Peter C. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Transcriptional firing helps to drive NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI

(2016) Esil Aleyd et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

(2016) Ian K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis

(2016) Helen L. Wright et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil-derived chemokines on the road to immunity

(2016) Cristina Tecchio et al.   SEMINARS IN IMMUNOLOGY

Human neutrophils in auto-immunity

(2016) Nathalie Thieblemont et al.   SEMINARS IN IMMUNOLOGY

Cytokine-mediated induction of MHC class II in human neutrophils is dependent on NADPH oxidase activity

(2015) Boris K. Pliyev et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NET formation can occur independently of RIPK3 and MLKL signaling

(2015) Poorya Amini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Defining the phenotype of neutrophils following reverse migration in zebrafish

(2015) Felix Ellett et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies

(2015) Huw B. Thomas et al.   PLoS One

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

(2015) Julia Spengler et al.   Arthritis & Rheumatology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation

(2014) Flavia S Lakschevitz et al.   Cellular & Molecular Immunology

Myeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis

(2014) A. Nzeusseu Toukap et al.   FREE RADICAL RESEARCH

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy

(2014) Helen L. Wright et al.   RHEUMATOLOGY

Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo

(2014) Helen L. Wright et al.   RHEUMATOLOGY

Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility

(2014) Chanchal Sur Chowdhury et al.   ARTHRITIS RESEARCH & THERAPY

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

(2013) Gerd R Burmester et al.   LANCET

RNA-Seq Reveals Activation of Both Common and Cytokine-Specific Pathways following Neutrophil Priming

(2013) Helen L. Wright et al.   PLoS One

Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis

(2013) Robert Stockley et al.   RESPIRATORY MEDICINE

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

(2013) V. Romero et al.   Science Translational Medicine

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy

(2011) H. L. Wright et al.   RHEUMATOLOGY

Changes in expression of membrane TNF, NF- B activation and neutrophil apoptosis during active and resolved inflammation

(2010) H. L. Wright et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature

(2008) Fernanda M. Coelho et al.   ARTHRITIS AND RHEUMATISM

Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice

(2008) T M Cunha et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid

(2008) S. H. Wong et al.   RHEUMATOLOGY

Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

(2008) Greg Parsonage et al.   ARTHRITIS RESEARCH & THERAPY

The dual effects of TNF  on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1

(2007) A. Cross et al.   BLOOD