Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels

(2020) Leigh D. Plant et al.   Cell Reports

Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

(2020) Hua-Qian Yang et al.   eLife

Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels

(2020) Samantha C. Salvage et al.   Biomolecules

AMPK-mediated degradation of Nav1.5 through autophagy

(2019) Xuehua Liu et al.   FASEB JOURNAL

UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density

(2019) Bo Tang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia

(2019) Qin Yang et al.   MOLECULAR GENETICS AND GENOMICS

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

Dysfunctional Nav1.5 channels due to SCN5A mutations

(2018) Dan Han et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure

(2018) Anyu Zhou et al.   HEART RHYTHM

A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage dependent sodium channel

(2018) Debora Baroni et al.   HUMAN MUTATION

Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression

(2018) Valentin Sottas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA

(2018) Anyu Zhou et al.   Journal of the American Heart Association

Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Nav1.5

(2018) Zhijie Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation: Personalized Medicine for Long QT Syndrome

(2018) Wandi Zhu et al.   CIRCULATION RESEARCH

The ER exit sites are specialized ER zones for the transport of cargo proteins from the ER to the Golgi apparatus

(2018) Kazuo Kurokawa et al.   JOURNAL OF BIOCHEMISTRY

Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Nav1.5 clarify the molecular basis of Brugada syndrome

(2018) Gang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity

(2018) Yi Guan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel

(2018) Ravi Vaidyanathan et al.   Frontiers in Physiology

SCN5A Variants: Association With Cardiac Disorders

(2018) Wenjia Li et al.   Frontiers in Physiology

Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy

(2017) Adam M. Noyes et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mechanisms of noncovalent β subunit regulation of Na V channel gating

(2017) Wandi Zhu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Transcriptional regulation of the sodium channel gene ( SCN5A ) by GATA4 in human heart

(2017) Anna Tarradas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes

(2017) Karan R. Chadda et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Voltage-gated sodium channels assemble and gate as dimers

(2017) Jérôme Clatot et al.   Nature Communications

Electrophysiology and metabolism of caveolin-3-overexpressing mice

(2016) Jan M. Schilling et al.   BASIC RESEARCH IN CARDIOLOGY

Lateral Membrane-Specific MAGUK CASK Down-Regulates Na V 1.5 Channel in Cardiac MyocytesNovelty and Significance

(2016) Catherine A. Eichel et al.   CIRCULATION RESEARCH

Ranolazine for Congenital Long-QT Syndrome Type III

(2016) Ehud Chorin et al.   Circulation-Arrhythmia and Electrophysiology

A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channels

(2016) Xiangming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5

(2016) Yuan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late sodium current: A mechanism for angina, heart failure, and arrhythmia

(2016) Jonathan C. Makielski   TRENDS IN CARDIOVASCULAR MEDICINE

Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states

(2015) Aurélie Mercier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p

(2015) Yuanyuan Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology

(2015) Nicola Detta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Genetic defects in a His-Purkinje system transcription factor,IRX3, cause lethal cardiac arrhythmias

(2015) Akiko Koizumi et al.   EUROPEAN HEART JOURNAL

Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications

(2015) Céline Marionneau et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel

(2014) Pedro Beltran-Alvarez et al.   AMINO ACIDS

Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo

(2014) Michael A. Makara et al.   CIRCULATION RESEARCH

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart

(2014) Pedro Beltran-Alvarez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Deletion of FoxO1 leads to shortening of QRS by increasing Na+ channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit

(2014) Benzhi Cai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Retention mechanisms for ER and Golgi membrane proteins

(2014) Caiji Gao et al.   TRENDS IN PLANT SCIENCE

MOG1 Rescues Defective Trafficking of Na v 1.5 Mutations in Brugada Syndrome and Sick Sinus Syndrome

(2013) Susmita Chakrabarti et al.   Circulation-Arrhythmia and Electrophysiology

Unfolded Protein Response Regulates Cardiac Sodium Current in Systolic Human Heart Failure

(2013) Ge Gao et al.   Circulation-Arrhythmia and Electrophysiology

Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel

(2013) Pedro Beltran-Alvarez et al.   FEBS LETTERS

Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction

(2013) Andrew R. Ednie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A

(2013) Jianding Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Silencing of desmoplakin decreases connexin43/Nav1.5 expression and sodium current in HL-1 cardiomyocytes

(2013) QIANHUAN ZHANG et al.   Molecular Medicine Reports

Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

(2012) Stefania Rizzo et al.   CARDIOVASCULAR RESEARCH

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

(2012) N. Gaborit et al.   DEVELOPMENT

p.D1690N Nav1.5 rescues p.G1748D mutation gating defects in a compound heterozygous Brugada syndrome patient

(2012) Lucía Núñez et al.   HEART RHYTHM

TBX5 drives Scn5a expression to regulate cardiac conduction system function

(2012) David E. Arnolds et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactive Oxygen Species Suppress Cardiac NaV1.5 Expression through Foxo1

(2012) Weike Mao et al.   PLoS One

A Brugada syndrome mutation (p.S216L) and its modulation by p.H558R polymorphism: standard and dynamic characterization

(2011) Stefano Marangoni et al.   CARDIOVASCULAR RESEARCH

Biology of cardiac sodium channel Nav1.5 expression

(2011) M. B. Rook et al.   CARDIOVASCULAR RESEARCH

Role of RBM25/LUC7L3 in Abnormal Cardiac Sodium Channel Splicing Regulation in Human Heart Failure

(2011) Ge Gao et al.   CIRCULATION

Fibroblast Growth Factor Homologous Factor 13 Regulates Na + Channels and Conduction Velocity in Murine Hearts

(2011) Chuan Wang et al.   CIRCULATION RESEARCH

Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel

(2011) Thomas C. Atack et al.   CIRCULATION RESEARCH

A Novel Strategy Using Cardiac Sodium Channel Polymorphic Fragments To Rescue Trafficking-Deficient SCN5A Mutations

(2011) Krekwit Shinlapawittayatorn et al.   Circulation-Cardiovascular Genetics

Alternative Splicing of the Cardiac Sodium Channel Creates Multiple Variants of Mutant T1620K Channels

(2011) Stefan Walzik et al.   PLoS One

Towards a Functional Understanding of Protein N-Terminal Acetylation

(2011) Thomas Arnesen   PLOS BIOLOGY

Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels

(2010) Hai Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Na v 1.5 in Cardiomyocytes

(2010) Séverine Petitprez et al.   CIRCULATION RESEARCH

Sudden infant death syndrome–associated mutations in the sodium channel beta subunits

(2010) Bi-Hua Tan et al.   HEART RHYTHM

Structure and function of splice variants of the cardiac voltage-gated sodium channel Nav1.5

(2010) Annett Schroeter et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Readthrough of nonsense mutation W822X in the SCN5A gene can effectively restore expression of cardiac Na+ channels

(2009) Siyong Teng et al.   CARDIOVASCULAR RESEARCH

Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes†

(2009) Takeshi Aiba et al.   CARDIOVASCULAR RESEARCH

Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes

(2009) Priscila Y. Sato et al.   CIRCULATION RESEARCH

Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation

(2009) Hiroshi Watanabe et al.   Circulation-Arrhythmia and Electrophysiology

How do ER export motifs work on ion channel trafficking?

(2009) Melanie Mikosch et al.   CURRENT OPINION IN PLANT BIOLOGY

Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay

(2009) N. V. Munshi et al.   DEVELOPMENT

Use-dependent block of cardiac late Na+ current by ranolazine

(2009) Sridharan Rajamani et al.   HEART RHYTHM

Caveolae, ion channels and cardiac arrhythmias

(2009) Ravi C. Balijepalli et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy

(2008) Junbo Ge et al.   Circulation-Arrhythmia and Electrophysiology

Ranolazine Shortens Repolarization in Patients with Sustained Inward Sodium Current Due to Type-3 Long-QT Syndrome

(2008) ARTHUR J. MOSS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

NF-κB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II

(2007) Lijuan L. Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY