Selective Serotonin Reuptake Inhibitor Pharmaco-Omics: Mechanisms and Prediction

TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response

(2020) Ming-Fen Ho et al.   MOLECULAR PSYCHIATRY

ERICH3: vesicular association and antidepressant treatment response

(2020) Duan Liu et al.   MOLECULAR PSYCHIATRY

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

(2019) Krishna C. Vadodaria et al.   MOLECULAR PSYCHIATRY

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

(2019) Krishna C. Vadodaria et al.   MOLECULAR PSYCHIATRY

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

(2019) Joel Gelernter et al.   BIOLOGICAL PSYCHIATRY

Pharmacogenomics‐Driven Prediction of Antidepressant Treatment Outcomes: A Machine Learning Approach with Multi‐Trial Replication

(2019) Arjun P. Athreya et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Catechol O‐Methyltransferase Pharmacogenomics: Challenges and Opportunities

(2019) Ming‐Fen Ho et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Integration of machine learning and pharmacogenomic biomarkers for predicting response to antidepressant treatment: can computational intelligence be used to augment clinical assessments?

(2019) Arjun P Athreya et al.   PHARMACOGENOMICS

Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUN☺D study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial

(2018) Tadashi Kato et al.   BMC Medicine

Assessment of Peripheral Serotonin Synthesis Using Stable Isotope-Labeled Tryptophan

(2018) Martine Gehin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Augmentation of Physician Assessments with Multi-Omics Enhances Predictability of Drug Response: A Case Study of Major Depressive Disorder

(2018) Arjun Athreya et al.   IEEE Computational Intelligence Magazine

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics

(2018) Duan Liu et al.   Translational Psychiatry

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics

(2018) Gregory McInnes et al.   BIOINFORMATICS

The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases

(2018) Drew Neavin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Shared and distinct transcriptomic cell types across neocortical areas

(2018) Bosiljka Tasic et al.   NATURE

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

(2018) Raymond K. Walters et al.   NATURE NEUROSCIENCE

Pharmacogenomics: Precision Medicine and Drug Response

(2017) Richard M. Weinshilboum et al.   MAYO CLINIC PROCEEDINGS

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Pharmacometabolomics informs pharmacogenomics

(2016) Drew Neavin et al.   Metabolomics

TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics

(2016) M Gupta et al.   MOLECULAR PSYCHIATRY

Erratum: The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response

(2016) J M Biernacka et al.   Translational Psychiatry

Generation of functional human serotonergic neurons from fibroblasts

(2015) K C Vadodaria et al.   MOLECULAR PSYCHIATRY

Direct conversion of human fibroblasts to induced serotonergic neurons

(2015) Z Xu et al.   MOLECULAR PSYCHIATRY

Generation of serotonin neurons from human pluripotent stem cells

(2015) Jianfeng Lu et al.   NATURE BIOTECHNOLOGY

Modulating the serotonin system in the treatment of major depressive disorder

(2014) Debbi Ann Morrissette et al.   CNS SPECTRUMS

Treatment Outcomes of Depression

(2014) David A. Mrazek et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

Origins and implications of pluripotent stem cell variability and heterogeneity

(2013) Patrick Cahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of immune genes in the association between depression and inflammation: A review of recent clinical studies

(2012) Chiara Bufalino et al.   BRAIN BEHAVIOR AND IMMUNITY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder

(2012) D Sasayama et al.   PHARMACOGENOMICS JOURNAL

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics

(2012) Y Ji et al.   PHARMACOGENOMICS JOURNAL

Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial

(2012) Boadie W Dunlop et al.   Trials

Cross-national epidemiology of DSM-IV major depressive episode

(2011) Evelyn Bromet et al.   BMC Medicine

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Genomics and Drug Response

(2011) Liewei Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project

(2010) Rudolf Uher et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder

(2009) Holly A. Garriock et al.   BIOLOGICAL PSYCHIATRY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE