Article
Environmental Sciences
Zhenxin Wang, Dan Shao, Shu Wu, Zhigang Song, Shourong Shi
Summary: This study demonstrates the beneficial effects of dietary dimethylglycine (DMG) in reducing heat stress-induced intestine injury. DMG supplementation improves growth performance and repairs gut barrier integrity, while modulating the composition of gut microbiota and enhancing microbiota-gut-brain axis metabolism function. These findings provide insights into a novel mechanism by which gut microbiota can improve host health.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Gastroenterology & Hepatology
Clara Delaroque, Melissa Chervy, Andrew T. Gewirtz, Benoit Chassaing
Summary: The study suggests that overcrowded housing may promote stress, dysbiosis of microbiota, inflammation, and metabolic diseases. Experimental evidence from mice showed that overcrowding led to changes in behavior, corticosterone levels, and gut inflammation.
Article
Chemistry, Multidisciplinary
Do-Wan Kim, Hye-Seon Jeong, Eunseo Kim, Hyomin Lee, Chang-Hyung Choi, Sei-Jung Lee
Summary: A strategy utilizing hydrogel microcapsules as an oral carrier enhances the survival and retention of mesenchymal stem cells in the gastrointestinal tract, effectively treating inflammatory bowel disease in a mouse model.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Porntipha Vitheejongjaroen, Anongnard Kasorn, Narathip Puttarat, Fabien Loison, Malai Taweechotipatr
Summary: The results of this study suggest that B. animalis MSMC83 has a beneficial role in alleviating oxidative stress in rats by increasing the expression of antioxidant enzymes and reducing pro-inflammatory cytokines. It also restores microbiota diversity after D-galactose injection.
Article
Plant Sciences
Yu Wang, Dong Zhen, Danni Fu, Yao Fu, Xuan Zhang, Guohua Gong, Chengxi Wei
Summary: 1,8-Cineole (1,8-CIN) has been shown to improve cardiomyocyte viability and reduce cardiac hypertrophy, cytoplasmic vacuole formation, myofiber loss, and fibrosis. Additionally, 1,8-CIN attenuates apoptosis induced by endoplasmic reticulum stress through inhibiting miR-206-3p.
Review
Pharmacology & Pharmacy
Suxin Yuan, Zhengyao Cai, Xingzhao Luan, Haibo Wang, Yi Zhong, Li Deng, Jian Feng
Summary: The pathogenesis of diabetic cardiomyopathy is complex, involving oxidative stress, inflammation, insulin resistance, apoptosis, and autophagy. Some studies suggest that gut microbiota and its metabolites can influence the development of diabetic cardiomyopathy by regulating these mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shenhai Gong, Yinglin Feng, Yunong Zeng, Huanrui Zhang, Meiping Pan, Fangjie He, Rong Wu, Jingrui Chen, Jiuling Lu, Siyou Zhang, Songhua Yuan, Xia Chen
Summary: The study revealed that cisplatin treatment disrupted gut microbiota in mice, and gut microbiota depletion by antibiotics protected against hepatotoxicity. Antibiotic treatment reduced inflammation and oxidative stress levels in the liver. Fecal microbiota transplantation also confirmed the role of microbiota in individual susceptibility to cisplatin-induced hepatotoxicity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Jumana Abuqwider, Angela Di Porzio, Valentina Barrella, Cristina Gatto, Giuseppina Sequino, Francesca De Filippis, Raffaella Crescenzo, Maria Stefania Spagnuolo, Luisa Cigliano, Gianluigi Mauriello, Susanna Iossa, Arianna Mazzoli
Summary: This study found that microencapsulation can effectively preserve the effectiveness of probiotics in the gastrointestinal tract and protect them from the negative effects of a Western diet. It has significant implications for improving gut function.
FRONTIERS IN NUTRITION
(2023)
Review
Food Science & Technology
Min Wu, Qingying Luo, Rongxuan Nie, Xingpan Yang, Zizhong Tang, Hong Chen
Summary: Polyphenols, as natural compounds derived from plants, have attracted increasing scientific interest for their potential anti-aging benefits in modulating oxidative damage, inflammation, autophagy, and gut microbiota. Research on novel polyphenol-based strategies and clinical trials are encouraged for the development of holistic anti-aging therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Sha Liu, Bin Wang, Ling Lin, Wei Xu, Zhi-Hua Gong, Wen-Jun Xiao
Summary: L-Theanine can alleviate heat stress by modulating gut microbiota, metabolites, and immunity, indicating its potential as a natural active ingredient for anti-heat stress food products.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Gastroenterology & Hepatology
Tushar K. Das, Bhanu P. Ganesh
Summary: The microbiota-gut-brain axis is a crucial pathway that contributes to the pathogenesis of Alzheimer's disease (AD) by altering gut microbiota and increasing oxidative stress and inflammation. The relationship between specific bacteria and brain dysfunction in AD pathology is not fully understood. This review explores the connections between oxidative stress, inflammation, and gut dysbiosis in AD and suggests potential preventative and therapeutic strategies.
Article
Biochemistry & Molecular Biology
Yizhi Zhang, Jinglu Hu, Xingshuang Song, Jing Dai, Ziyan Tang, Guiyu Huang, Wencheng Jiao, Yanping Wu, Chenyun Wang, Lina Du, Yiguang Jin
Summary: This study demonstrates that supplementation of probiotics can improve the gut microenvironment and alleviate the cognitive impairment caused by radiation-induced brain injury (RIBI). Microcapsules containing Lactobacillus reuteri (L. reuteri) were prepared, which significantly enhanced the survival of L. reuteri in the harsh stomach environment. The treatment with L. reuteri microcapsules improved the behavior of RIBI mice and reduced pathological damage in the hippocampus and intestines, as well as decreased the levels of TNF-alpha and IL-6.
Article
Biochemistry & Molecular Biology
Yuting Zhang, Huimin Chen, Wei Cong, Ke Zhang, Yimin Jia, Lei Wu
Summary: Heat stress can hinder the growth performance of broilers, leading to economic losses. The study found that chronic heat stress resulted in a decrease in total bile acids and an increase in cholic acid, chenodeoxycholic acid, and taurolithocholic acid in broilers. The expression of CYP8B1 and BSEP increased in the liver, while the expression of FGF19 decreased in the ileum of heat-stressed broilers. Significant changes in gut microbial composition were also observed, with the enrichment of Peptoniphilus being positively correlated with the increased serum level of taurolithocholic acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Ali Calik, Nima K. Emami, Ghislain Schyns, Mallory B. White, Maria C. Walsh, Luis F. Romero, Rami A. Dalloul
Summary: This study evaluated the effects of vitamin E and selenium supplementation on broilers exposed to elevated temperature. The results showed that vitamin E and selenium supplementation improved antioxidant status, regulated cytokine responses, and modified the ileal microbiota.
Article
Biochemistry & Molecular Biology
Hugo C. Barreto, Beatriz Abreu, Isabel Gordo
Summary: Iron availability is tightly regulated in the mammalian gut, and the adaptive allele of the iron regulation gene iscR undergoes fluctuating selection influenced by antibiotics, microbiota, and the immune system. Host immune protein Lipocalin-2 plays a major role in shaping the selection on iscR.