ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts

Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation

(2020) Yi Feng et al.   EBioMedicine

Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty

(2020) Jing Xu et al.   Particle and Fibre Toxicology

Strategy for hypertrophic scar therapy: Improved delivery of triamcinolone acetonide using mechanically robust tip-concentrated dissolving microneedle array

(2019) Shiqi Lin et al.   JOURNAL OF CONTROLLED RELEASE

Combined inhibition of Bcl-2 and NFκB synergistically induces cell death in cutaneous T-cell lymphoma

(2019) Tabea C. Froehlich et al.   BLOOD

Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis

(2019) Yongqiang Xiao et al.   International Journal of Nanomedicine

Acne Scarring Management: Systematic Review and Evaluation of the Evidence

(2018) Shashank Bhargava et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

MicroRNA-519d inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting Sirtuin 7

(2018) Xiaoqian Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts

(2018) Tobias Kuehl et al.   MATRIX BIOLOGY

Wild-type p53-modulated autophagy and autophagic fibroblast apoptosis inhibit hypertrophic scar formation

(2018) Jihong Shi et al.   LABORATORY INVESTIGATION

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

(2017) Anja Moncsek et al.   HEPATOLOGY

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

(2017) David Lagares et al.   Science Translational Medicine

Pioneering apoptosis-targeted cancer drug poised for FDA approval

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

The role of myofibroblasts in wound healing

(2016) B. Hinz   Current Research in Translational Medicine

A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria

(2015) X. Wang et al.   CLINICAL CANCER RESEARCH

Intralesional injection of adipose-derived stem cells reduces hypertrophic scarring in a rabbit ear model

(2015) Qi Zhang et al.   Stem Cell Research & Therapy

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

(2012) Thanh-Trang Vo et al.   CELL

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors

(2011) Leena Gandhi et al.   JOURNAL OF CLINICAL ONCOLOGY

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes

(2010) J. A. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY