Article
Chemistry, Analytical
Haiyue Peng, Ting Wang, Guorui Li, Jing Huang, Quan Yuan
Summary: The dual-locked NIR probe, MB-m-borate, utilizes two biomarkers as triggers for increased specificity and precision in diagnosis. Upon H2O2-TYR cascade activation, MB-m-borate shows fluorescence and specifically responds to melanoma cells, making it a robust probe for precise detection of melanoma. The probe is also successfully applied for in vivo diagnosis of melanoma in a xenogeneic mouse model.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Michelle W. Lee, Elizabeth Wei-Chia Luo, Carlos Silvestre-Roig, Yashes Srinivasan, Kiyotaka Akabori, Patricia Lemnitzer, Nathan W. Schmidt, Ghee Hwee Lai, Christian D. Santangelo, Oliver Soehnlein, Gerard C. L. Wong
Summary: The study demonstrates the ability to create peptides or proteins that inhibit histone H4 membrane permeation, reducing cell death and inflammation. Experiments show that apoMP(1) can dose-dependently alleviate H4 cytotoxicity. Furthermore, administration of apoMP(1) is found to strongly prevent organ tissue damage.
Article
Medicine, Research & Experimental
Johannes Zeller, Karen S. Cheung Tung Shing, Tracy L. Nero, James D. McFadyen, Guy Krippner, Balazs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K. Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G. Kather, Bernd Kammerer, Kevin J. Woollard, Prerna Sharma, Craig J. Morton, Geoffrey Pietersz, Michael W. Parker, Karlheinz Peter, Steffen U. Eisenhardt
Summary: C-reactive protein (CRP) is highly upregulated during inflammatory reactions and exhibits pro-inflammatory effects. We discovered a mechanism in which CRP undergoes conformational changes, resulting in highly inflammatory forms. By designing a low molecular weight CRP inhibitor that mimics phosphocholine, we demonstrated its ability to inhibit CRP-driven inflammation while preserving its pathogen-defense functions. This represents a promising and potentially broad-spectrum anti-inflammatory therapy.
EMBO MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Taeyeon Hong, Jiyeon Ham, Jisoo Song, Gwonhwa Song, Whasun Lim
Summary: Brassinin exerts antiproliferative effects on HCC cells by reducing PCNA activity and inducing cell cycle arrest, increasing mitochondrial Ca2+ levels, generating ROS, and regulating AKT and MAPK signaling pathways. Co-administration with pharmacological inhibitors enhances its antiproliferative effects.
Article
Pharmacology & Pharmacy
Yaqian Feng, Lei Tao, Guoqiang Wang, Zhen Li, Mingming Yang, Weishen He, Xincheng Zhong, Yong Zhang, Jinliang Yang, Shinghu Cheung, Fiona McDonald, Ligong Chen
Summary: Research shows that aspirin can reduce the occurrence of colon tumors in mice by blocking COX metabolism and reducing pro-inflammatory cytokine levels. Additionally, aspirin inhibits tumor growth by suppressing the Wnt pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Jianhua Xu, Wenge Zeng, Tiantian Liu, Zhenda Wan, Xin Yang, Jun Chen, Fei Liu
Summary: The present study aimed to evaluate the effects of lncRNA TINCR on colon cancer development and investigate the underlying mechanisms. Tissues from colon cancer patients were used to measure TINCR expression and examine its association with clinicopathology and prognosis. Knockdown of TINCR resulted in reduced cell proliferation, increased apoptosis, and decreased invasion and migration, indicating its involvement in colon cancer development. The study also suggested that TINCR regulates autophagy, potentially playing a role in colon cancer progression.
FOOD SCIENCE & NUTRITION
(2023)
Article
Oncology
David P. Molkentine, Jessica M. Molkentine, Kathleen A. Bridges, David R. Valdecanas, Annika Dhawan, Reshub Bahri, Andrew J. Hefner, Manish Kumar, Liangpeng Yang, Mohamed Abdelhakiem, Phillip M. Pifer, Vlad Sandulache, Aakash Sheth, Beth M. Beadle, Howard D. Thames, Kathryn A. Mason, Curtis R. Pickering, Raymond E. Meyn, Heath D. Skinner
Summary: Squamous cell carcinoma driven by HPV is more sensitive to radiotherapy, and the p16 protein increases this sensitivity by activating a signaling pathway that affects various proteins involved in transcription and degradation, ultimately reducing homologous recombination and improving the response to radiotherapy.
Article
Cell Biology
Baijiao An, Wenyan Nie, Jinhui Hu, Yangyang Fan, Haoran Nie, Mengxuan Wang, Yaxuan Zhao, Han Yao, Yuanyuan Ren, Chuanchuan Zhang, Mengna Wei, Wei Li, Jiadai Liu, Chunhua Yang, Yin Zhang, Xingshu Li, Geng Tian
Summary: This study developed a tyrosine kinase inhibitor 1D228 that targets c-Met and TRK to effectively inhibit tumor cell proliferation and migration. In vivo models demonstrated that 1D228 had strong anti-tumor effects on gastric and liver tumors. Mechanistic studies showed that 1D228 inhibited the phosphorylation of TRKB and c-Met, as well as the key functions of tumor angiogenesis. These findings suggest that 1D228 could be a promising next-generation inhibitor for c-Met and TRK, offering a novel treatment strategy for cancer patients with abnormal expressions of these targets.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Medicinal
Xiangping Deng, Baohua Xie, Qiuzi Li, Yuan Xiao, Zhiye Hu, Xiaofei Deng, Pingping Fang, Chune Dong, Hai-Bing Zhou, Jian Huang
Summary: This study identified a new ER modulator, 34b, which showed antiproliferative effects against breast cancer cells and induced apoptosis through mitochondrial dysfunction. In vivo experiments demonstrated that 34b had better tumor suppression than tamoxifen. Therefore, this compound has potential as a candidate for treating breast cancer, particularly tamoxifen-resistant breast cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, Moshe Arditi
Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Integrative & Complementary Medicine
Boyu Pan, Yafei Xia, Zilu Gao, Gang Zhao, Liangjiao Wang, Senbiao Fang, Liren Liu, Shu Yan
Summary: The study found that Cinnamomi Ramulus (CR) has potential therapeutic effects on cancer, especially colon cancer. Through oral administration, CR inhibited the growth of colon cancer cells in mice and suppressed the viability and motility of colon cancer cells in vitro. The study identified 111 core therapeutic targets of CR, and enrichment analysis showed that CR induces apoptosis and cell cycle arrest in colon cancer cells by blocking the Akt/ERK signaling pathways.
Article
Immunology
Ji Zhu, Hang Chen, Jianan Guo, Chen Zha, Dezhao Lu
Summary: This study investigated the protective role of sodium tanshinone IIA sulfonate (STS) in atherosclerosis (AS). The results showed that STS can regulate endothelial cell mitochondrial function and pyroptosis through an AMPK-dependent mitochondrial pathway. The study found that STS treatment enhanced maintenance of mitochondrial homeostasis and inhibited mitochondrial ROS overproduction via AMPK, thereby improving endothelial cell pyroptosis during AS. These findings suggest that STS has potential therapeutic effects in AS through its antioxidant and anti-inflammatory properties.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Jibo Han, Shanshan Dai, Lingfeng Zhong, Xiaowen Shi, Xiaoxi Fan, Xin Zhong, Wante Lin, Lan Su, Shuang Lin, Bingjiang Han, Jianjiang Xu, Xia Hong, Weijian Huang, Bozhi Ye
Summary: This study found that the activation of GSDMD in cardiac hypertrophy can cause mitochondrial dysfunction, leading to STING activation and enhanced cardiac hypertrophy. Elimination of GSDMD can reduce cardiac hypertrophy, suggesting the potential of GSDMD as a therapeutic target for hypertrophy-related heart diseases.
Article
Multidisciplinary Sciences
Yan Gu, Yanrong Chen, Lai Wei, Shuang Wu, Kaicheng Shen, Chengxiang Liu, Yan Dong, Yang Zhao, Yue Zhang, Chi Zhang, Wenling Zheng, Jiangyi He, Yunlong Wang, Yifei Li, Xiaoxin Zhao, Hongwei Wang, Jun Tan, Liting Wang, Qi Zhou, Ganfeng Xie, Houjie Liang, Juanjuan Ou
Summary: Loss of ABHD5 promotes the activation of c-Met via a non-canonical pathway, sustaining the stemness of colorectal cancer cells.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Chong Zeng, Jie Lin, Ketao Zhang, Huohui Ou, Ke Shen, Qingbo Liu, Zibo Wei, Xinhuai Dong, Xiaokang Zeng, Liming Zeng, Weidong Wang, Jie Yao
Summary: This study investigates the role and molecular mechanism of SHARPIN in cholangiocarcinoma (CCA). The results suggest that SHARPIN is upregulated in CCA tissue and is involved in cell proliferation. Silencing of SHARPIN leads to accumulation of reactive oxygen species and impaired mitochondrial function, which ultimately induce excessive oxidative stress and cell ferroptosis. Targeting SHARPIN may be a promising strategy for the treatment of CCA.
Article
Materials Science, Paper & Wood
Yong Zhang, Mei Yang, Yuan Zhou, Anrong Yao, Yanting Han, Yidong Shi, Fei Cheng, Mi Zhou, Puxin Zhu, Lin Tan
Summary: A sandwich Janus membrane was constructed through sequential electrospinning, which showed good mechanical properties, high permeability and selective separation ability. The CA/PU transition layer improved the interfacial compatibility and enhanced the membrane performance.
Article
Environmental Sciences
Gang Chen, Mi Zhou, Shixiang Gu, Jinming Chen, Lei Wu
Summary: This study compared the applicability of six albedo models in different regions of China through statistical analysis. The results showed that ZeM model performed the best among the selected 12 stations, while IeM model provided acceptable estimations in locations where albedo data is readily available. Additionally, the number of input parameters is not the sole key factor in determining the predictive performance of ground albedo models.
Article
Engineering, Civil
Kewei Liu, Megan Walske, Mi Zhou, Xihong Zhang
Summary: The use of rammed earth as a construction material has gained attention for its sustainability and low-cost potential. However, the mechanical performance of stabilized rammed earth, particularly under dynamic loading, is not well understood. This study experimentally investigates the quasi-static and dynamic material properties of cement and calcium carbonate residue stabilized rammed earth, and derives empirical formulae for the dynamic increase factor.
INTERNATIONAL JOURNAL OF PROTECTIVE STRUCTURES
(2023)
Article
Polymer Science
Zejian He, Haifeng Shao, Nannan Zhang, Jie Li, Hai Xiao, Tianhang Weng, Mi Zhou, Bianying Wen, Yulong Chen
Summary: This study designed and synthesized three amide nucleating agents with different symmetries to investigate the effect of symmetry on PLLA crystallization. It was found that the C3 symmetric amide structure exhibited the best performance as an efficient nucleation site.
JOURNAL OF POLYMER SCIENCE
(2023)
Review
Engineering, Environmental
Huijuan Wu, Weiqiong Zheng, Ran Zhu, Mi Zhou, Xiancheng Ren, Yinghan Wang, Chong Cheng, Hongju Zhou, Sujiao Cao
Summary: This article comprehensively summarizes and discusses the most important advances in engineering MOF nanoarchitectures for efficient water electrolysis. First, the methods of modulating the coordination structures and metal atom environments of MOF and MOF-derived catalysts are reviewed, and then their applications in water splitting are discussed based on the coordination structure and local atomic environment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Bing Yang, Mi Zhou, Yuan Meng, Keming Chen, Jie Xu, Xiangfu Huang, Yucheng Liu, Lingli Li, Lili Ma, Mingyan Chen
Summary: Chemical oxidation as a pretreatment for petroleum-contaminated soil, coupled with bioremediation, can have serious impacts on indigenous microorganisms and available nutrients. This study found that hydrogen peroxide treatments significantly promoted the removal of total petroleum hydrocarbons (TPH), especially in the initial days, and also affected the levels of dissolved nutrients. Both chemical oxidation and nutrients contribute to changes in microbial community structure and diversity. However, the long-term effects of H2O2 as a pretreatment had little impact on the soil indigenous microbial community structure and actually facilitated the continuous removal of TPH by indigenous microorganisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Runyu Fu, Jianguo Wang, Jianping Wang, Mi Zhou, Cai Li, Yating Zhao, Yadong Fan
Summary: This paper establishes a holistic model of a 500 kV GIS step-up substation equipment in a coastal power plant using the Electromagnetic Transient Program (EMTP). It investigates the VFTO waveform generated in different operations and analyzes its impact on equipment.
IET GENERATION TRANSMISSION & DISTRIBUTION
(2023)
Article
Engineering, Electrical & Electronic
Mi Zhou, Weihan Zhao, Shengquan Zheng, Yongming Guo, Zehong Yang, Jianguo Wang, Li Cai, Yadong Fan
Summary: This study establishes a simulation model to investigate the lightning inductive characteristics between parallel cables. The research findings indicate that an increase in the horizontal distance between cables leads to a decrease in the cable induced voltage. Additionally, linear correlations exist between the height difference or disturbed cable length and the cable induced voltage, reaching maximum when the cables are at the same height and of equal length.
IET SCIENCE MEASUREMENT & TECHNOLOGY
(2023)
Article
Spectroscopy
DongFei Li, Shuo Zhang, Hongsheng Jia, Mingxing Song, Ying Zhang, Haibo Li, Mi Zhou
Summary: In this study, high pressure Raman research was conducted on lithium perchlorate crystal, and it was found that the crystal undergoes phase transformations under different pressure conditions, which has significant implications for its performance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Cardiac & Cardiovascular Systems
Haoyi Yao, Kaijie Qin, Yun Liu, Yi Yang, Jiaxi Zhu, Anqing Chen, Zhe Wang, Xiaofeng Ye, Mi Zhou, Haiqing Li, Jiapei Qiu, Qiang Zhao, Yunpeng Zhu
Summary: Individualized dual antiplatelet therapy (DAPT) based on CYP2C19 genotype and platelet aggregation test (PAgT) was associated with a lower risk of major adverse cardiovascular events (MACE) and a similar risk of major bleeding in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Environmental
Mei Zhang, Yuting Wen, Zhangheng Huang, Xin Qin, Mi Zhou, Dexuan Xiao, Weitong Cui, Zhiqiang Liu, Yunfeng Lin
Summary: A novel nanomedicine was developed for the treatment of rheumatoid arthritis, which carries methotrexate and uses aptamer targeting tumor necrosis factor-alpha. This targeted nanomedicine accumulates in the inflammatory joints, reducing systemic toxicity and decreasing joint damage.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Medicinal
Xiangying Zhang, Haotian Gao, Haojie Wang, Zhihang Chen, Zhe Zhang, Xinchong Chen, Yan Li, Yifei Qi, Renxiao Wang
Summary: Researchers have developed a graph neural network model called PLANET, which predicts protein-ligand binding affinity using 3D and 2D structures as input. PLANET was trained with multiple objectives and achieved comparable performance to other deep learning models in terms of scoring power and docking power. It also outperformed other models in virtual screening trials. PLANET's accuracy and efficiency make it a useful tool for large-scale virtual screening.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Honggang Xiang, Ruiqi Liu, Xiangying Zhang, Ran An, Mi Zhou, Chang Tan, Qing Li, Minyi Su, Chun Guo, Lu Zhou, Yingxia Li, Renxiao Wang
Summary: Research has discovered that T1742 can block the interactions between ATG5-ATG16L1 and ATG5-TECAIR, effectively inhibiting cellular autophagy. This validates the importance of small-molecule inhibitors targeting ATG5-mediated protein-protein interactions in autophagy regulation.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Yan Li, Zhe Zhang, Renxiao Wang
Summary: This study presents an improved version of the empirical method HydraMap, called HydraMap v.2, which utilizes statistical potentials to predict hydration sites and compute desolvation energy during protein-ligand binding. The statistical potentials for protein-water interactions were updated based on crystal protein structures, and new potentials derived from solvated structures of small organic molecules were introduced to evaluate ligand-water interactions. HydraMap v.2 successfully predicts and compares hydration sites in a binding pocket before and after ligand binding, identifying key water molecules involved in the binding process. It also demonstrates good correlation between desolvation energies and ligand binding affinities in six target proteins, providing a cost-effective solution for estimating desolvation energy and guiding lead optimization in structure-based drug discovery.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Chemistry, Multidisciplinary
Tiantian Li, Yuting Deng, Xiao Rong, Chao He, Mi Zhou, Yuanjiao Tang, Hongju Zhou, Chong Cheng, Changsheng Zhao
Summary: This review comprehensively summarizes the main advances and applications of tellurium-based nanomaterials (Te NMs) in electrocatalysis. The engineering strategies and principles to enhance the electrocatalytic activity and stability of Te NMs are discussed, including chemical/physical/multiplex templating strategies, heteroatom doping, and phase engineering. The typical applications of Te NMs in electrocatalysis are also presented. Finally, the key issues, challenges, and development trends of Te NMs as electrocatalysts are highlighted.
